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公开(公告)号：EP4423093A1
公开(公告)日：2024-09-04
申请号：EP22812449.1
申请日：2022-10-24
申请人： Consejo Superior de Investigaciones Científicas (CSIC) , Universidad de Sevilla , Academia Sinica
发明人： GARCÍA FERNÁNDEZ, José Manuel , ORTIZ MELLET, Carmen , GONZÁLEZ CUESTA, Manuel , HERRERA GONZÁLEZ, Irene , CHANG, Ya-Jen , LAI, Alan Chuan-Ying
IPC分类号： C07D498/04 , A61P37/02 , A61K31/4355 , C07H15/06 , C07H15/26
CPC分类号： C07H15/26 , C07H15/06 , C07D498/04 , A61P37/02
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公开(公告)号：EP4186528A1
公开(公告)日：2023-05-31
申请号：EP21383082.1
申请日：2021-11-30
发明人： Moreno Herrero, Jorge , Haas, Heinrich , Erbar, Stephanie , Stahl, Theo Benjamin , Garcia Fernandez, Jose Manuel , Benito Hernandez, Juan Manuel , López Fernández, José , Ortiz Mellet, María del Carmen , de la Cruz Ruiz, Noelia , Gonzalez Cuesta, Manuel
摘要： The present disclosure provides complexes comprising i) a cationic oligosaccharide comprising one or more cationic moieties bonded to a trehalose, a sucrose, or an n-glucose moiety, where n is 2-6; ii) a surfactant; and iii) one or more additives selected from: a sterol, a helper lipid, an immunomodulator, and a targeting molecule.
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3.发明公开
公开(公告)号：EP3570342A1
公开(公告)日：2019-11-20
申请号：EP18382341.8
申请日：2018-05-18
发明人： RUBINO, Andrea , GALISTEO LÓPEZ, Juan Francisco , MÍGUEZ GARCÍA, Hernán Ruy , CALVO ROGGIANI, Mauricio , ANAYA MARTÍN, Miguel
摘要： The invention relates to a material which comprises ABX 3 compounds with perovskite crystalline structure infiltrated within a porous metal oxide film, wherein A and B are cations , and X is an halide. The invention also relates to the process to obtain the referred material and its use for light emitting, color converter and surface protective coating.
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公开(公告)号：EP3390702B1
公开(公告)日：2019-09-04
申请号：EP16809446.4
申请日：2016-12-15
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公开(公告)号：EP2819928B1
公开(公告)日：2019-01-23
申请号：EP13755917.5
申请日：2013-02-28
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公开(公告)号：EP3419626A1
公开(公告)日：2019-01-02
申请号：EP17707003.4
申请日：2017-02-23
发明人： SÁNCHEZ CÉSPEDES, Javier , PACHÓN IBÁÑEZ, María Eugenia , PACHÓN DÍAZ, Jerónimo , MARTÍNEZ AGUADO, Pablo , CEBRERO CANGUEIRO, Tania , VEGA PÉREZ, José Manuel , IGLESIAS GUERRA, Fernando , VEGA HOLM, Margarita , CANDELA LENA, José Ignacio , MAZZOTTA, Sarah
IPC分类号： A61K31/495 , C07D241/02 , A61P31/12
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7.发明公开COMPUTERIZED OPTICAL ANALYSIS METHODS OF MR (MAGNETIC RESONANCE) IMAGES FOR QUANTIFYING OR DETERMINING LIVER LESIONS 审中-公开用于量化或确定肝脏损伤的MR（磁共振）图像的计算机光学分析方法
公开(公告)号：EP3271738A1
公开(公告)日：2018-01-24
申请号：EP16710221.9
申请日：2016-03-17
申请人： Servicio Andaluz de Salud , Universidad De Sevilla , Centro de Investigación Biomédica en Red (CIBER)
IPC分类号： G01R33/56 , G06T7/00 , A61B5/055 , G01R33/561
CPC分类号： G01R33/5608 , A61B5/055 , A61B5/4244 , G01R33/5601 , G01R33/5602 , G01R33/5607 , G01R33/5617 , G06T7/0012 , G06T2207/10088 , G06T2207/30056
摘要： A method computerized optically analyzes methods of conventional, preferably non-contrast-enhanced, MR (magnetic resonance) images of the liver. The method enables the detection of steatohepatitis by NASH-MRI and significant fibrosis by Fibro-MRI in patients suffering from NAFLD. The method enables forecasting the rate of disease progression, to support therapeutic decision-making, and to monitor potential therapeutic effects.
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8.发明公开METHOD OF SINTERING ELECTRICALLY CONDUCTING POWDERS AND AN APPARATUS FOR CARRYING OUT SAID METHOD 审中-公开烧结电导粉末的方法和用于实施所述方法的设备
公开(公告)号：EP3208015A1
公开(公告)日：2017-08-23
申请号：EP16382069.9
申请日：2016-02-19
发明人： MONTES MARTOS, Juan Manuel , CINTAS FÍSICO, Jesús , GALLARDO FUENTES, José María , DE PAULA GÓMEZ CUEVAS, Francisco , TORRES HERNÁNDEZ, Yadir , AGOTE BELOQUI, Íñigo , LAGOS GÓMEZ, Miguel Ángel , IRAZUSTA ARRUTI, Aitor
IPC分类号： B22F3/087 , B01J19/08 , B22F3/105 , B30B11/00 , B22F3/16 , C22C21/00 , C22C29/08 , C22C29/10 , C22C32/00
CPC分类号： B22F3/105 , B22F3/087 , B22F3/164 , B22F2003/1051 , B22F2201/50 , B22F2202/06 , B22F2301/15 , B22F2301/205 , B22F2301/40 , B22F2998/10 , C22C14/00 , C22C21/00 , C22C29/08 , C22C29/10 , C22C32/0052
摘要： The method comprises placing the powders in an electrically isolating mold, applying a pressure to the powders between 100 and 500MPa and applying to the powders a sintering current at a sintering voltage during a sintering time, for sintering the powders. Before applying the sintering current density, applying an activation current density lower than the sintering current density at an activation voltage greater than the sintering voltage during an activation time lower than the sintering time, to reduce the electrical resistance of the powders.
摘要翻译： 该方法包括将粉末放置在电隔离模具中，对粉末施加100-500MPa的压力，并在烧结时间期间将烧结电流施加到粉末上以烧结粉末。 在施加烧结电流密度之前，在低于烧结时间的活化时间期间，在大于烧结电压的活化电压下施加比烧结电流密度低的活化电流密度，以降低粉末的电阻。
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9.发明公开METHOD AND DEVICE FOR PRODUCING SIMPLE AND COMPOUND MICROMETRE-SIZED EMULSIONS 审中-公开生产简单和复合微米尺寸乳液的方法和装置
公开(公告)号：EP3187252A1
公开(公告)日：2017-07-05
申请号：EP15836842.3
申请日：2015-08-25
发明人： GORDILLO ARIAS DE SAAVEBRA, José Manuel , DEL CAMPO CORTÉS, Francisco , EVANGELIO SÁNCHEZ, Álvaro
IPC分类号： B01F3/08
CPC分类号： B01F3/0807 , B01F13/0062 , B01F2215/0431 , B01F2215/045 , B01F2215/0495
摘要： The invention relates to a method for producing simple and compound emulsions having micrometre-sized, controllable diameters and coatings, using a device formed by elements having characteristic dimensions of the order of a millimetre. The emulsions are produced using the suction produced by the flow of a viscous liquid through the section of a millimetre-sized capillary tube. According to a parametric analysis, the liquid or the pair of liquids to be emulsified form a simple or compound steady capillary jet of micrometre diameter, by the action of the co-flow of the emulsifying liquid and the favourable pressure gradient produced. The jet breaks because of capillary instability, forming simple or compound monodisperse micro-drops. The invention disclosed in this description can be used in industrial sectors where the production of simple and compound, monodisperse, homogeneous emulsions having micrometric-sized, controllable diameters and coatings is an essential part of the process.
摘要翻译： 本发明涉及使用由具有特征尺寸为几毫米量级的元件形成的装置来制造具有微米尺寸，可控直径和涂层的简单和复合乳液的方法。 使用由粘性液体流过毫米尺寸毛细管部分产生的抽吸产生乳液。 根据参数分析，通过乳化液体的共流和产生的有利压力梯度的作用，待乳化的液体或一对液体形成微米级直径的简单或复合稳定毛细管射流。 由于毛细管不稳定性，射流断裂，形成简单或复合的单分散微滴。 在本说明书中公开的本发明可以用于工业部门，其中生产具有微米尺寸，可控直径和涂层的简单和复合的单分散均质乳液是该方法的基本部分。
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10.发明公开COMBINATIONS OF AGGREGATING PROTEINS AND MOLECULAR CHAPERONE PROTEINS FOR THE TREATMENT OF PROTEINOPATHIES OR CONFORMATIONAL DISEASES 审中-公开蛋白质聚集和分子伴侣蛋白可用于治疗或PROTEINOPATHIEN构象病组合
公开(公告)号：EP3045180A1
公开(公告)日：2016-07-20
申请号：EP14844286.6
申请日：2014-09-15
IPC分类号： A61K38/17 , C07K16/18 , A61K39/395 , A61P25/16
CPC分类号： A61K39/0007 , A61K38/00 , A61K2039/5154 , A61K2039/55566 , A61K2039/57 , A61K2039/572 , A61K2039/575 , A61K2039/6043 , C07K14/47 , C07K16/18 , C07K16/40 , C07K2317/20
摘要： HSPs (chaperones or heat-shock proteins) have two very valuable characteristics that can be productively exploited in a specific manner in order to "intelligently" manipulate the immune response so as to treat "conformational" disorders or "proteinopathies":
- the classic chaperone functions thereof; and
- the more recently discovered immunoactive properties thereof.
On the basis thereof, the authors of the present invention have combined a peptide, a protein or a polypeptide associated with a "conformational disease" with a biologically active or functional HSP, resulting in a different immunoactive complex which is advantageous for treating the "conformational disease" in question associated with the peptide, protein or polypeptide used.摘要翻译： 热休克蛋白（伴侣或热休克蛋白）有两个非常有价值的特性都可以高效地以“智能”操纵的免疫反应，从而治疗“构象”障碍或“蛋白病”利用以特定的方式 - 经典伴侣 它们的功能; 和 - 其最近发现的免疫活性性质。 在此基础上它们，本发明的作者已经结合的肽，蛋白质或具有“构象疾病”与生物活性或功能性HSP相关联的多肽，在一个不同的免疫活性复杂造成的所有其可用于治疗的“构象有利 病“问题与使用的肽，蛋白质或多肽相关。
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