摘要:
The present invention refers to antiandrogens, particularly nonsteroidal antiandrogens, or salts derived thereof, for use in the treatment of cancer, wherein the cancer is characterized by the presence of androgen receptor-negative (AR-) tumor cells.
摘要:
The invention relates to a computer-implemented method for classifying events present in a sample, wherein each event is characterized by a multidimensional set of parameters obtained by means of hardware and/or software, wherein the values of the parameters associated with each event define the position coordinates of said event in a multidimensional space. Said method comprises the following stages: a) clustering the events in groups, b) checking if within each formed group there is a connection between events exceeding a maximum distance threshold, c) calculating the affinity between each pair of previously generated sample groups, d) comparing each sample group with at least one reference group stored in at least one database, e) classifying the sample groups based on the comparisons with the reference groups.
摘要:
This invention relates to methods to detect the presence of cancer infiltration of the Central Nervous System (CNS) based on the detection of soluble proteins, preferably, in cerebrospinal fluid samples and vitreous fluid. The invention also relates to kits to perform the methods of the invention.
摘要:
The invention relates, in general, to markers of obesity and lipodystrophy. In particular, the expression level of the SLUG gene or its expression products can be used as such a marker. Furthermore, the invention additionally relates to the use of SLUG as a therapeutic and diagnostic target for these pathologies. The invention further relates to a method of treating a disorder associated with increased or decreased fat storage in a mammal comprising modulating the activity or level of the SLUG protein or the SLUG gene in the mammal.
摘要:
The composition comprises fungi belonging to one or more species of genus Trichoderma, selected from amongst T. asperellum, T. atroviride, T. inhamatum and the mixtures thereof. Said composition is useful as biological control agent of phytopathogenic organisms. The composition is suitable for protecting or treating plants and vegetable material against infections and diseases caused by plant pathogens and/or for stimulating plant growth and/or inducing systemic resistance in plants against diseases caused by phytopathogenic organisms and/or controlling biodeterioration agents of materials. The invention can be used in the field of agriculture.
摘要:
The composition comprises fungi belonging to one or more species of fungi of the genus Trichoderma , selected from T. asperellum, T. atroviride, T. inhamatum and their mixtures, useful as an agent for the biological control of phytopathogenic organisms. The composition is suitable for protecting or treating plants and plant material against infections and diseases caused by plant pathogens, and/or to stimulate plant growth, and/or to induce systemic resistance in plants to diseases caused by phytopathogenic organisms, and/or to control biodeterioration agents of materials. Of application in Agriculture.
摘要:
Procedure for the study of the functional activation of leukocytes, platelets and other cells, produced in vivo or induced in vitro, based on the stabilization of cytoplasmic membrane proteins and its detection using quantitative cytometric methods in the absence of any further manipulation of the sample. The procedure includes the sequential incubation of the sample with: 1) either one or an admixture of more than one protease specific inhibitors and, 2) a combination of several fluorochrome-conjugated monoclonal antibodies; to analyze the expression of surface proteins using immunofluorescence methods and quantitative cytometry.