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公开(公告)号：EP3286174A1
公开(公告)日：2018-02-28
申请号：EP16719712
申请日：2016-04-22
发明人： BENDER JOHN A , LOPEZ OMAR D , NGUYEN VAN N , YANG ZHONG , WANG ALAN XIANGDONG , WANG GAN , MEANWELL NICHOLAS A , BENO BRETT R , FRIDELL ROBERT A , BELEMA MAKONEN , THANGATHIRUPATHY SRINIVASAN
IPC分类号： C07D317/66 , A61K31/17 , A61K31/18 , A61K31/4245 , A61P31/18 , C07C237/22 , C07C275/24 , C07C311/03 , C07D213/61 , C07D235/26 , C07D271/12 , C07D277/62 , C07D285/14 , C07D295/192
CPC分类号： C07D213/61 , C07C237/22 , C07C271/22 , C07C275/24 , C07C307/06 , C07C311/06 , C07C311/19 , C07C323/60 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D235/26 , C07D271/12 , C07D277/62 , C07D285/14 , C07D295/192 , C07D317/66 , C07K5/022
摘要： Compounds of Formulas I-VI, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth. Formula I is exemplified below: Formula (i)
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公开(公告)号：EP3286212A1
公开(公告)日：2018-02-28
申请号：EP16718817
申请日：2016-04-14
发明人： KRYSTAL MARK R , WENSEL DAVID L , DAVIS JONATHAN
CPC分类号： C07K14/78 , A61K38/00 , C07K14/005 , C07K2319/00 , C07K2319/30 , C07K2319/31 , C12N2740/16122
摘要： The invention is directed to polypeptides comprising a CD4 binding moiety, a gp41 binding moiety, a HIV fusion peptide inhibitor moiety and combinations thereof. More specifically, the present invention relates to polypeptides comprising a fibronectin-based scaffold domain protein that binds CD4, a fibronectin-based scaffold domain protein that binds the N17 domain of gp41, and a HIV fusion peptide inhibitor or combinations thereof. The invention also relates to the use of the innovative proteins in therapeutic applications to treat HIV.
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公开(公告)号：EP3286166A1
公开(公告)日：2018-02-28
申请号：EP16720285
申请日：2016-04-22
发明人： BENDER JOHN A , GENTLES ROBERT G , PENDRI ANNAPURNA , WANG ALAN XIANGDONG , MEANWELL NICHOLAS A , BENO BRETT R , FRIDELL ROBERT A , BELEMA MAKONEN , NGUYEN VAN N , YANG ZHONG , WANG GAN , KUMARAVEL SELVAKUMAR , THANGATHIRUPATHY SRINIVASAN , BORA RAJESH ONKARDAS , HOLEHATTI SHILPA MAHESHWARAPPA , METTU MALLIKARJUNA RAO , PANDA MANORANJAN
IPC分类号： C07C307/06 , A61K31/381 , A61K31/395 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/428 , A61K31/64 , A61P31/18 , C07C307/10 , C07D215/12 , C07D215/38 , C07D217/08 , C07D217/22 , C07D231/12 , C07D231/56 , C07D233/64 , C07D235/08 , C07D241/04 , C07D333/72
CPC分类号： C07D205/04 , C07C307/06 , C07C307/10 , C07C311/08 , C07C2602/08 , C07D207/325 , C07D209/08 , C07D209/30 , C07D209/32 , C07D209/86 , C07D211/96 , C07D213/42 , C07D215/12 , C07D215/38 , C07D217/08 , C07D217/22 , C07D231/12 , C07D231/56 , C07D233/64 , C07D235/08 , C07D241/04 , C07D249/12 , C07D261/08 , C07D263/32 , C07D277/28 , C07D277/62 , C07D295/185 , C07D295/26 , C07D333/72 , C07D417/12 , C07D417/14 , C07D471/04 , C07D498/04
摘要： Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth: (I)
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