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公开(公告)号：EP3849544A1
公开(公告)日：2021-07-21
申请号：EP19860912.5
申请日：2019-09-13
IPC分类号： A61K31/41 , A61K31/422 , C07D413/04 , C07D471/04
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公开(公告)号：EP3230277A4
公开(公告)日：2018-04-25
申请号：EP15866917
申请日：2015-12-11
IPC分类号： C07D403/14 , A61K31/4196 , A61K31/4439 , A61K31/4985 , A61P35/00 , A61P37/00 , C07D401/14 , C07D403/04 , C07D413/14
CPC分类号： A61K31/4184 , A61K31/4196 , A61K31/42 , A61K31/437 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/498 , A61K31/4985 , A61K31/517 , A61K31/52 , A61K31/5377 , A61K45/06 , A61K2300/00 , A61P35/00 , A61P37/00 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D473/34
摘要： The present application relates to substituted heterocycles compound of Formula I and pharmaceutical compositions thereof useful for the inhibition of BET protein function by binding to bromodomains (Formula I).
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3.发明授权
公开(公告)号：EP3010917B1
公开(公告)日：2018-01-31
申请号：EP14822480.1
申请日：2014-06-20
发明人： LIU, Shuang , QUINN, John, Frederick , DUFFY, Bryan, Cordell , WANG, Ruifang , JIANG, May, Xiaowu , MARTIN, Gregory, Scott , ZHAO, He , ELLIS, Michael , WAGNER, Gregory, Steven , YOUNG, Peter, Ronald
IPC分类号： C07D413/14 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/4709 , C07D413/04 , C07D417/14
CPC分类号： A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/538 , A61K45/06 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , Y02A50/467
摘要： The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.
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公开(公告)号：EP3227280A1
公开(公告)日：2017-10-11
申请号：EP15864529.1
申请日：2015-12-01
发明人： JIANG, May, Xiaowu , MOLINO, Bruce, Francis , LIU, Shuang , WANG, Ruifang , DUFFY, Bryan, Cordell , QUINN, John, Frederick , WAGNER, Gregory, Steven
IPC分类号： C07D413/04 , A61K31/4439 , C07D413/14 , C07D417/14
CPC分类号： A61K31/4439 , A61K31/444 , A61K31/506 , A61K45/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , Y02A50/467
摘要： The disclosure relates to substituted pyridines, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.
摘要翻译： 本公开涉及取代的吡啶，其可用于通过结合溴结构域来抑制BET蛋白功能，以及它们在治疗中的用途。
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公开(公告)号：EP3849980A1
公开(公告)日：2021-07-21
申请号：EP19860308.6
申请日：2019-09-13
发明人： WEN, Feng , CHEN, Jiahui , WEN, Xianghui , EDGAR, Mark, T. , HANSEN, Henrik, C.
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00 , A61P9/00
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公开(公告)号：EP3010918B1
公开(公告)日：2018-08-15
申请号：EP14822511.3
申请日：2014-06-20
发明人： LIU, Shuang , QUINN, John, Frederick , DUFFY, Bryan, Cordell , WANG, Ruifang , JIANG, May, Xiaowu , MARTIN, Gregory, Scott , ZHAO, He , ELLIS, Michael , WAGNER, Gregory, Steven , YOUNG, Peter, Ronald
IPC分类号： C07D413/14 , A61K31/395 , A61K31/422 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4985 , A61K31/506 , A61K31/517 , A61K31/538 , C07D405/14 , C07D413/04 , C07D417/14 , C07D487/04
CPC分类号： A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/538 , A61K45/06 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , Y02A50/467
摘要： The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.
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公开(公告)号：EP3227280A4
公开(公告)日：2018-05-30
申请号：EP15864529
申请日：2015-12-01
发明人： JIANG MAY XIAOWU , MOLINO BRUCE FRANCIS , LIU SHUANG , WANG RUIFANG , DUFFY BRYAN CORDELL , QUINN JOHN FREDERICK , WAGNER GREGORY STEVEN
IPC分类号： C07D413/04 , A61K31/4439 , C07D413/14 , C07D417/14
CPC分类号： A61K31/4439 , A61K31/444 , A61K31/506 , A61K45/06 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , Y02A50/467
摘要： The disclosure relates to substituted pyridines, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.
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公开(公告)号：EP3849550A1
公开(公告)日：2021-07-21
申请号：EP19861171.7
申请日：2019-09-13
IPC分类号： A61K31/437 , A61K31/506 , A61K31/519 , A61K31/565 , A61P35/00 , C07D401/14 , C07D471/04 , C07D487/04 , C07J31/00
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公开(公告)号：EP3849549A1
公开(公告)日：2021-07-21
申请号：EP19859446.7
申请日：2019-09-13
IPC分类号： A61K31/437 , A61K31/5025 , A61P35/00 , C07D471/04 , C07D471/06
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公开(公告)号：EP2935253B1
公开(公告)日：2018-08-01
申请号：EP13864406.7
申请日：2013-12-19
发明人： LIU, Shuang , DUFFY, Bryan, Cordell , QUINN, John, Frederick , JIANG, May, Xiaowu , WANG, Ruifang , MARTIN, Gregory, Scott , ZHAO, He , MOLINO, Bruce, Francis , YOUNG, Peter, Ronald
IPC分类号： C07D413/04 , C07D413/14 , C07D417/04 , A61K31/395 , A61K31/4439 , A61K31/501 , A61K31/506 , A61P3/10 , A61P25/00 , A61P29/00 , A61P35/00 , A61P31/18 , A61P43/00
CPC分类号： A61K31/5377 , A61K31/4375 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/472 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/506 , A61K31/513 , A61K45/06 , C07D213/64 , C07D213/74 , C07D237/04 , C07D237/14 , C07D237/22 , C07D237/32 , C07D401/12 , C07D413/04 , C07D413/14 , C07D417/04 , Y02A50/467
摘要： The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.
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