SCREENING METHODS FOR HEAT-SHOCK RESPONSE MODULATORS
    3.
    发明公开
    SCREENING METHODS FOR HEAT-SHOCK RESPONSE MODULATORS 审中-公开
    筛选方法,热休克反应调节剂

    公开(公告)号:EP2300821A1

    公开(公告)日:2011-03-30

    申请号:EP09758771.1

    申请日:2009-06-03

    IPC分类号: G01N33/50 G01N33/574

    CPC分类号: G01N33/5035

    摘要: High-throughput methods are provided for quantitatively measuring the modulation of heat shock protein (HSP) expression in a cell by exposing the cell to at least one stress and measuring cellular stress responses. High-throughput methods for identifying modulators (activators or inhibitors) of HSP or HSF expression in a cell by treating the cell with an agent, such as a compound or composition, exposing the cell to a stress, and measuring responses of the cell to the stress in the presence or absence of the agent are also provided. Devices useful in performing high-throughput methods of the invention, and modulators identified using such methods, are also provided.