公开(公告)号：EP1235569B1

公开(公告)日：2004-02-11

申请号：EP00988591.4

申请日：2000-11-16

申请人： responsif GmbH

发明人： BERTLING, Wolf

IPC分类号： A61K31/37 ,  A61K45/06 ,  A61P7/00

CPC分类号： A61K45/06 ,  A61K31/00 ,  A61K31/37 ,  A61K31/12 ,  A61K2300/00

摘要： The invention relates to a medicament or a combination of compatible medicaments for combined administration. Said medicament or combination of medicaments contains at least one active agent and at least one antagonist of said active agent.

公开(公告)号：EP1585540B1

公开(公告)日：2011-04-27

申请号：EP04703150.5

申请日：2004-01-19

申请人： responsif GmbH

发明人： BERTLING, Wolf

IPC分类号： A61K38/17 ,  A61P35/00

CPC分类号： A61K38/2013 ,  A61K9/0019 ,  A61K9/08 ,  A61K38/1703 ,  A61K38/191 ,  A61K38/193 ,  A61K38/20 ,  A61K2300/00

摘要： The invention relates to a medicament for tumor therapy, containing a first and a second molecule in an effective concentration, the first molecule representing a1) Annexin V or a molecule that is largely similar thereto, or a2) an effective fragment of Annexin V or the molecule that is largely similar thereto, and the second molecule representing b1) a cytokine or a molecule that is largely similar thereto, or b2) an effective fragment of a cytokine or the molecule that is largely similar thereto.

公开(公告)号：EP1585540A1

公开(公告)日：2005-10-19

申请号：EP04703150.5

申请日：2004-01-19

申请人： responsif GmbH

发明人： BERTLING, Wolf

IPC分类号： A61K38/17 ,  A61P35/00

CPC分类号： A61K38/2013 ,  A61K9/0019 ,  A61K9/08 ,  A61K38/1703 ,  A61K38/191 ,  A61K38/193 ,  A61K38/20 ,  A61K2300/00

摘要： The invention relates to a medicament for tumor therapy, containing a first and a second molecule in an effective concentration, the first molecule representing a1) Annexin V or a molecule that is largely similar thereto, or a2) an effective fragment of Annexin V or the molecule that is largely similar thereto, and the second molecule representing b1) a cytokine or a molecule that is largely similar thereto, or b2) an effective fragment of a cytokine or the molecule that is largely similar thereto.

公开(公告)号：EP1814565A1

公开(公告)日：2007-08-08

申请号：EP05769742.7

申请日：2005-07-09

申请人： responsif GmbH

发明人： REISER, Christian ,  HESS, Jürgen ,  BRINKMAN, Marc

IPC分类号： A61K38/00 ,  C12N15/86

CPC分类号： C07K14/005 ,  A61K38/162 ,  A61K39/0011 ,  A61K2039/55555 ,  A61K2039/6075 ,  A61K2039/64 ,  C07K2319/00 ,  C12N7/00 ,  C12N2710/22022 ,  C12N2750/14022 ,  A61K2300/00

摘要： The invention relates to a use of pentamers for producing a medicament used for the treatment of a tumor disease or an autoimmune disease in a mammal or human. Said pentamers are formed of five subunits, each of which comprises a first amino acid sequence and at least one second amino acid sequence that adjoins the N-terminal or C-terminal end of the first amino acid sequence. The first amino acid sequence is composed of an amino acid sequence that forms a structure of the coat protein of a papovavirus or parvovirus or a portion of said amino acid sequence which is sufficient to form the pentamers while the second amino acid sequence represents an amino acid sequence forming at least one epitope of the tumor or at least one epitope causing the autoimmune disease, the tumor not being caused by the papovavirus or parvovirus. The inventive pentamers are not provided in an assembled form as capsoids.

公开(公告)号：EP1474124A1

公开(公告)日：2004-11-10

申请号：EP03704610.9

申请日：2003-02-13

申请人： responsif GmbH

发明人： BERTLING, Wolf, M. ,  RANBY, Mats

IPC分类号： A61K31/194 ,  A61P7/02

CPC分类号： A61K33/06 ,  A61K31/194 ,  A61K2300/00

摘要： The invention relates to the use of an active ingredient for producing a medicament for inhibiting the coagulation of blood, said active ingredient being isocitrate or an active derivative thereof.

公开(公告)号：EP1425303A2

公开(公告)日：2004-06-09

申请号：EP02762464.2

申请日：2002-08-24

申请人： responsif GmbH

发明人： HERRMANN, Martin ,  BERTLING, Wolf ,  KALDEN, Joachim, R. ,  VOLL, Reinhard, E. ,  MANFREDI, Angelo ,  KOLOWOS, Wasilis ,  REISER, Christian ,  WOITH, Walter

IPC分类号： C07K14/47

CPC分类号： A61K38/1709

摘要： The invention relates to the use of a protein for producing a medicament for stimulating an innate non specific immune system, wherein the protein contains a) an annexine V or a largely similar molecule thereto or b) an active fragment of annexine V or a largely similar molecule thereto.

公开(公告)号：EP1366362A2

公开(公告)日：2003-12-03

申请号：EP01988862.7

申请日：2001-10-26

申请人： responsif GmbH

发明人： HERRMANN, Martin ,  KALDEN, Joachim, Robert ,  BERTLING, Wolf ,  REISER, Christian ,  GAIPL, Udo ,  HEYDER, Petra ,  WOITH, Walter

IPC分类号： G01N33/50 ,  G01N33/569

CPC分类号： G01N33/56972 ,  G01N33/5091 ,  G01N2333/42 ,  G01N2510/00

摘要： The invention relates to a method for the identification of apoptotic and necrotic cells in a cell suspension, comprising the following steps: a) contacting a first sample taken from said cell suspension with a lectin that is suitable to bind to sugar structures contained in the membrane of apoptotic and necrotic cells; b) acidifying the first sample; c) detecting the amount of lectin bound by the apoptotic and necrotic cells.

公开(公告)号：EP1888620A1

公开(公告)日：2008-02-20

申请号：EP06707650.5

申请日：2006-03-28

申请人： responsif GmbH

发明人： REICHEL, Christoph ,  RÜHLAND, Claus ,  HESS, Jürgen ,  REISER, Christian

IPC分类号： C07K14/005

CPC分类号： C12N7/00 ,  A61K2039/5256 ,  C07K14/005 ,  C07K2319/00 ,  C12N2710/22022 ,  C12N2710/22023 ,  C12N2710/22051 ,  Y02A50/412 ,  Y02A50/466

摘要： The invention relates to a method for producing virus-type particles containing an active substance. Proteins, which comprise a first amino acid sequence which is derived from a first virus protein, and fusion proteins are assembled in order to form the virus-type particles. The proteins and the fusion proteins are coexpressed in yeast cells.

公开(公告)号：EP1594538A2

公开(公告)日：2005-11-16

申请号：EP04711600.9

申请日：2004-02-17

申请人： responsif GmbH

发明人： HESS, Jürgen ,  NEUGEBAUER, Markus ,  STARK, Christoph ,  STRICH, Sandra ,  WALDERS, Birgit

IPC分类号： A61K39/13 ,  G01N33/53

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K47/646 ,  A61K47/6901 ,  A61K2039/5258 ,  C12N2770/22022

摘要： The invention relates to compositions to be administered to a living being, a method for marking agents that are administered to living beings, the use thereof, and an accelerated test.

公开(公告)号：EP1366362B1

公开(公告)日：2005-11-16

申请号：EP01988862.7

申请日：2001-10-26

申请人： responsif GmbH

发明人： HERRMANN, Martin ,  KALDEN, Joachim, Robert ,  BERTLING, Wolf ,  REISER, Christian ,  GAIPL, Udo ,  HEYDER, Petra ,  WOITH, Walter

IPC分类号： G01N33/50 ,  G01N33/569

CPC分类号： G01N33/56972 ,  G01N33/5091 ,  G01N2333/42 ,  G01N2510/00

摘要： The invention relates to a method for the identification of apoptotic and necrotic cells in a cell suspension, comprising the following steps: a) contacting a first sample taken from said cell suspension with a lectin that is suitable to bind to sugar structures contained in the membrane of apoptotic and necrotic cells; b) acidifying the first sample; c) detecting the amount of lectin bound by the apoptotic and necrotic cells.