公开(公告)号：EP0879219A1

公开(公告)日：1998-11-25

申请号：EP97941492.0

申请日：1997-09-10

申请人： Abbott Laboratories

发明人： HOCHLOWSKI, Jill, Edie ,  SOWIN, Thomas, J. ,  NORBECK, Daniel, W. ,  GRILLOT, Anne-Laure, Marie ,  SWENSON, Rolf, E.

IPC分类号： C07B61 ,  C08F8 ,  C08G85 ,  C40B70

CPC分类号： C40B50/16 ,  B01J2219/005 ,  B01J2219/00572 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/0072 ,  C07B2200/11 ,  C40B70/00 ,  Y10T436/13

摘要： The present invention relates to a process of coding and identifying individual members of a chemical combinatorial library synthesized on a plurality of solid supports which undergo mix and split synthesis. The process provides for tagging the solid supports with a coding identifier that is attached to the solid support and which can be decoded by infrared or Raman spectroscopy when directly attached to the support.

公开(公告)号：EP1250332A1

公开(公告)日：2002-10-23

申请号：EP00986489.3

申请日：2000-12-15

申请人： Abbott Laboratories

发明人： BASHA, Fatima, Z. ,  HINMAN, Mira, M. ,  KOPECKA, Hana, A. ,  SEARLE, Xenia, B. ,  SOWIN, Thomas, J. ,  WODKA, Dariusz ,  SUROWY, Carol ,  FALTYNEK, Connie, R.

IPC分类号： C07D309/04 ,  C07D295/20 ,  C07D309/12 ,  C07D405/12 ,  C07D417/12 ,  C07C275/32 ,  C07D207/12 ,  C07D295/08 ,  C07D241/08 ,  C07D405/04 ,  C07D235/26 ,  A61K31/35 ,  A61K31/40 ,  A61K31/41 ,  A61K31/445

CPC分类号： C07D295/096 ,  C07C275/32 ,  C07D207/12 ,  C07D235/26 ,  C07D241/08 ,  C07D295/205 ,  C07D295/215 ,  C07D309/04 ,  C07D309/12 ,  C07D405/04 ,  C07D405/12 ,  C07D417/12

摘要： A method of inhibiting interleukin 5 gene expression in a mammal comprising administering to a mammal in need of such treatment a pharmaceutically effective amount of one or more compounds selected from formula (I) and/or from formula (II).

公开(公告)号：EP1682555A1

公开(公告)日：2006-07-26

申请号：EP04800653.0

申请日：2004-11-03

申请人： ABBOTT LABORATORIES

发明人： TAO, Zhi-Fu ,  LIN, Nan-Horng ,  WANG, Le ,  SOWIN, Thomas, J. ,  SULLIVAN, Gerard, M. ,  TONG, Yunsong ,  PRZYTULINSKA, Magdalenna ,  LI, Gaoquan

IPC分类号： C07D498/08 ,  C07D498/18 ,  A61K31/4995 ,  A61K31/395 ,  A61P35/00

CPC分类号： C07D498/08 ,  C07D498/18

摘要： Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds

公开(公告)号：EP1023317A1

公开(公告)日：2000-08-02

申请号：EP98953379.9

申请日：1998-10-09

申请人： Abbott Laboratories

发明人： HOCHLOWSKI, Jill, E. ,  SOWIN, Thomas, J. ,  NORBECK, Daniel, W. ,  WADE, Warren, S. ,  WHITTERN, David, N.

IPC分类号： C07K1/04 ,  C07B61/00

CPC分类号： C40B50/16 ,  B01J2219/00576 ,  C07K1/047 ,  C40B99/00

摘要： The present invention relates to coding combinatorial chemical libraries synthesized on a plurality of solid supports by attaching 'tags' that comprise fluorine containing compounds in combinations and/or ratios. The tags can be decoded while attached to the solid support by fluorine nuclear magnetic resonance spectroscopy to follow the reaction history of individual beads, and to determine the particular member of the library that is attached on the bead.

公开(公告)号：EP0879219B1

公开(公告)日：2000-03-01

申请号：EP97941492.7

申请日：1997-09-10

申请人： Abbott Laboratories

发明人： HOCHLOWSKI, Jill, Edie ,  SOWIN, Thomas, J. ,  NORBECK, Daniel, W. ,  GRILLOT, Anne-Laure, Marie ,  SWENSON, Rolf, E.

IPC分类号： C07B61/00

CPC分类号： C40B50/16 ,  B01J2219/005 ,  B01J2219/00572 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/0072 ,  C07B2200/11 ,  C40B70/00 ,  Y10T436/13

摘要： The present invention relates to a process of coding and identifying individual members of a chemical combinatorial library synthesized on a plurality of solid supports which undergo mix and split synthesis. The process provides for tagging the solid supports with a coding identifier that is attached to the solid support and which can be decoded by infrared or Raman spectroscopy when directly attached to the support.

公开(公告)号：EP0724563B1

公开(公告)日：1999-09-01

申请号：EP94929340.1

申请日：1994-09-26

申请人： ABBOTT LABORATORIES

发明人： STUK, Timothy, L. ,  KERDESKY, Francis, A., J. ,  LIJEWSKI, Linda, M. ,  NORBECK, Daniel, W. ,  SCARPETTI, David ,  TIEN, Jien-Heh, J. ,  ALLEN, Michael, S. ,  LANGRIDGE, Denton, C. ,  MELCHER, Laura ,  RENO, Daniel, S. ,  SHAM, Hing, Leung ,  ZHAO, Chen ,  HAIGHT, Anthony, R. ,  LEANNA, M., Robert ,  MORTON, Howard, E. ,  ROBBINS, Timothy, A. ,  SOWIN, Thomas, J.

IPC分类号： C07C225/16 ,  C07C213/00 ,  C07C255/42 ,  C07C271/20 ,  C07C269/06 ,  C07C215/28 ,  C07C251/40

CPC分类号： C07D221/14 ,  C07B2200/07 ,  C07C213/00 ,  C07C215/28 ,  C07C225/16 ,  C07C251/40 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07C215/08

摘要： Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or R6 is as defined above and R7 is R7aOC (O)-wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R8 is hydrogen or -C(O)R' wherein R' is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.

公开(公告)号：EP0724563A1

公开(公告)日：1996-08-07

申请号：EP94929340.0

申请日：1994-09-26

申请人： ABBOTT LABORATORIES

发明人： STUK, Timothy, L. ,  KERDESKY, Francis, A., J. ,  LIJEWSKI, Linda, M. ,  NORBECK, Daniel, W. ,  SCARPETTI, David ,  TIEN, Jien-Heh, J. ,  ALLEN, Michael, S. ,  LANGRIDGE, Denton, C. ,  MELCHER, Laura ,  RENO, Daniel, S. ,  SHAM, Hing, Leung ,  ZHAO, Chen ,  HAIGHT, Anthony, R. ,  LEANNA, M., Robert ,  MORTON, Howard, E. ,  ROBBINS, Timothy, A. ,  SOWIN, Thomas, J.

IPC分类号： C07C213 ,  C07C215 ,  C07C225 ,  C07C227 ,  C07C229 ,  C07C231 ,  C07C233 ,  C07C251 ,  C07C255 ,  C07C269 ,  C07C271 ,  C07D209 ,  C07D221

CPC分类号： C07D221/14 ,  C07B2200/07 ,  C07C213/00 ,  C07C215/28 ,  C07C225/16 ,  C07C251/40 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07C215/08

摘要： Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or R6 is as defined above and R7 is R7aOC (O)-wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R8 is hydrogen or -C(O)R' wherein R' is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.