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1.发明公开CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHASE AND PROTEIN FARNESYLTRANSFERASE 失效环丁烷衍生物作为抑制剂鲨烯合酶和蛋白质法尼基转移
公开(公告)号：EP0821665A1
公开(公告)日：1998-02-04
申请号：EP96912978.0
申请日：1996-04-18
申请人： Abbott Laboratories
发明人： ARENDSEN, David, L. , BAKER, William, R. , FAKHOURY, Stephen, A. , FUNG, K., L., Anthony , GARVEY, David, S. , MCCLELLAN, William, J. , O'CONNOR, Stephen, J. , PRASAD, Rajnandan, N. , ROCKWAY, Todd, W. , ROSENBERG, Saul, H. , STEIN, Herman, H. , SHEN, Wang , STOUT, David, M. , SULLIVAN, Gerard, M. , AUGERI, David, J.
IPC分类号： A61K31 , A61P3 , A61P9 , A61P31 , A61P35 , A61P43 , C07C233 , C07C235 , C07D271 , C07D285 , C07D333
CPC分类号： C07C235/82 , C07C233/58 , C07C233/59 , C07C233/60 , C07C235/40 , C07C2601/04 , C07D333/20
摘要： The present invention provides a compound of formula (I) or (II) or a pharmaceutically acceptable salt thereof, which is useful for inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.
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2.发明授权CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHASE AND PROTEIN FARNESYLTRANSFERASE 失效CYCLOBUTAN-DERIVATE ALS INHIBITOREN DER SQUALEN-SYNTHASE UND DER PROTEIN FARNESYLTRANSFERASE
公开(公告)号：EP0821665B1
公开(公告)日：2001-10-04
申请号：EP96912978.2
申请日：1996-04-18
申请人： Abbott Laboratories
发明人： ARENDSEN, David, L. , BAKER, William, R. , FAKHOURY, Stephen, A. , FUNG, K., L., Anthony , GARVEY, David, S. , MCCLELLAN, William, J. , O'CONNOR, Stephen, J. , PRASAD, Rajnandan, N. , ROCKWAY, Todd, W. , ROSENBERG, Saul, H. , STEIN, Herman, H. , SHEN, Wang , STOUT, David, M. , SULLIVAN, Gerard, M. , AUGERI, David, J.
IPC分类号： C07C233/60 , C07D333/20 , C07C233/58 , C07C233/59 , C07C235/40 , A61K31/19 , A61K31/215 , A61K31/38 , A61K31/16
CPC分类号： C07C235/82 , C07C233/58 , C07C233/59 , C07C233/60 , C07C235/40 , C07C2601/04 , C07D333/20
摘要： The present invention provides a compound of formula (I) or (II) or a pharmaceutically acceptable salt thereof, which is useful for inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.
摘要翻译： 本发明提供式（II）化合物或其药学上可接受的盐，其可用于抑制蛋白质法呢基转移酶和癌基因蛋白Ras的法呢基化，制备本发明化合物的方法除了可用于 这些方法，药物组合物，以及使用这些化合物的方法。
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公开(公告)号：EP0543936A1
公开(公告)日：1993-06-02
申请号：EP91916458.0
申请日：1991-08-02
申请人： ABBOTT LABORATORIES
发明人： BAKER, William, R. , BOYD, Steven, A. , FUNG, Anthony, K., L. , STEIN, Herman, H. , DENISSEN, Jon, F. , HUTCHINS, Charles, W. , ROSENBERG, Saul, H.
CPC分类号： C07D451/06 , C07D211/46 , C07D401/12 , C07D405/12 , C07D413/10 , C07D451/14
摘要： Composé inhibant la rénine, de la formule (I), dans laquelle X représente O, NH ou S et G représentent un mime du site de clivage Leu-Val d'angiotensinogène; ou un sel un ester ou un promédicament pharmaceutiquement acceptable dudit composé; à condition que le composé ne soit pas N-(3-(4-morpholino)propyl)-5(S)-(2(S)-(1(S)-(4-méthoxyméthoxy)pipéridine-1-yl)carbonyl-2-phényl)éthoxyhéxanamido)-6-cyclohéxyl-4(S)-hydroxy-2(S)-isopropylhéxanamide.
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