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1.发明公开3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开3-（苯基烷氧基）-5-（苯基）一种癌的治疗作为激酶抑制剂的吡啶衍生物和相关化合物
公开(公告)号：EP1463505A2
公开(公告)日：2004-10-06
申请号：EP02790126.3
申请日：2002-12-12
申请人： Abbott Laboratories
发明人： LI, Qun , WOODS, Keith W. , ZHU, Gui-Dong , FISCHER, John P. , GONG, Jianchun , LI, Tongmei , GANDHI, Viraj , THOMAS, Sheela, A. , PACKARD, Garrick , SONG, Xiaohong , ABRAMS, Jason, N. , DIEBOLD, Robert , DINGES, Jurgen , HUTCHINS, Charles , STOLL, Vincent, S. , ROSENBERG, Saul, H. , GIRANDA, Vincent, L.
IPC分类号： A61K31/4439 , A61K31/444 , C07D401/12 , C07D401/14 , C07D401/04 , C07D475/02 , C07D213/63
摘要： Compounds having the formula (I), are useful for inhibiting protein kinases and for the treatment of cancer. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.
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公开(公告)号：EP0543936A1
公开(公告)日：1993-06-02
申请号：EP91916458.0
申请日：1991-08-02
申请人： ABBOTT LABORATORIES
发明人： BAKER, William, R. , BOYD, Steven, A. , FUNG, Anthony, K., L. , STEIN, Herman, H. , DENISSEN, Jon, F. , HUTCHINS, Charles, W. , ROSENBERG, Saul, H.
CPC分类号： C07D451/06 , C07D211/46 , C07D401/12 , C07D405/12 , C07D413/10 , C07D451/14
摘要： Composé inhibant la rénine, de la formule (I), dans laquelle X représente O, NH ou S et G représentent un mime du site de clivage Leu-Val d'angiotensinogène; ou un sel un ester ou un promédicament pharmaceutiquement acceptable dudit composé; à condition que le composé ne soit pas N-(3-(4-morpholino)propyl)-5(S)-(2(S)-(1(S)-(4-méthoxyméthoxy)pipéridine-1-yl)carbonyl-2-phényl)éthoxyhéxanamido)-6-cyclohéxyl-4(S)-hydroxy-2(S)-isopropylhéxanamide.
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公开(公告)号：EP1644008B1
公开(公告)日：2011-12-21
申请号：EP04753737.8
申请日：2004-06-01
IPC分类号： A61K31/635
CPC分类号： A61K31/635 , A61K31/00 , A61K31/44
摘要： Compositions comprising the cancer drug N-2(2-((4-hydroxyphenyl) amino)pyrid-3-yl)-4-methoxybenzenesulfonamide (ABT-751), continuous oral dosing schedule with said drug which binds to the colchicine site of tubulin ß-subunits, and methods of treating diseases using continuous dosing schedules are disclosed.
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公开(公告)号：EP1644008A2
公开(公告)日：2006-04-12
申请号：EP04753737.8
申请日：2004-06-01
IPC分类号： A61K31/635
CPC分类号： A61K31/635 , A61K31/00 , A61K31/44
摘要： Compositions comprising the cancer drug N-2(2-((4-hydroxyphenyl) amino)pyrid-3-yl)-4-methoxybenzenesulfonamide (ABT-751), continuous oral dosing schedule with said drug which binds to the colchicine site of tubulin ß-subunits, and methods of treating diseases using continuous dosing schedules are disclosed.
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公开(公告)号：EP1318978B1
公开(公告)日：2006-02-08
申请号：EP01971244.7
申请日：2001-09-20
申请人： ABBOTT LABORATORIES
发明人： MCCLELLAN, William , OOST, Thorsten , BRUNCKO, Milan , WANG, Xilu , AUGERI, David, J. , BAUMEISTER, Steven, A. , DICKMAN, Daniel, A. , DING, Hong , DINGES, Jurgen , FESIK, Stephen, W. , HAJDUK, Philip, J. , KUNZER, Aaron, R. , NETTESHEIM, David, G. , PETROS, Andrew, M. , ROSENBERG, Saul, H. , SHEN, Wang , THOMAS, Sheela, A. , WENDT, Michael, D.
IPC分类号： C07C311/51 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/58 , C07C323/60 , C07D209/08 , C07D209/96 , C07D213/61 , C07D213/70 , C07D215/48 , C07D221/20 , C07D263/56 , C07D277/62 , C07D277/64 , C07D295/14 , C07D295/20 , C07D333/28
CPC分类号： C07D207/404 , C07C311/51 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/58 , C07C323/60 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/28 , C07C2602/42 , C07C2602/44 , C07C2603/74 , C07D203/10 , C07D205/12 , C07D207/24 , C07D209/08 , C07D209/96 , C07D211/44 , C07D211/70 , C07D211/74 , C07D213/61 , C07D213/70 , C07D213/71 , C07D215/14 , C07D215/227 , C07D215/48 , C07D217/04 , C07D221/20 , C07D231/12 , C07D235/08 , C07D235/26 , C07D241/16 , C07D249/04 , C07D263/56 , C07D263/58 , C07D277/62 , C07D277/64 , C07D295/13 , C07D295/155 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D307/14 , C07D317/54 , C07D333/28 , C07D333/68 , C07D401/06 , C07D401/12 , C07D405/04 , C07D417/12 , C07D451/02
摘要： N-Benzoyl arylsulfonamides having the formula (I) are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.
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6.发明授权CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHASE AND PROTEIN FARNESYLTRANSFERASE 失效CYCLOBUTAN-DERIVATE ALS INHIBITOREN DER SQUALEN-SYNTHASE UND DER PROTEIN FARNESYLTRANSFERASE
公开(公告)号：EP0821665B1
公开(公告)日：2001-10-04
申请号：EP96912978.2
申请日：1996-04-18
申请人： Abbott Laboratories
发明人： ARENDSEN, David, L. , BAKER, William, R. , FAKHOURY, Stephen, A. , FUNG, K., L., Anthony , GARVEY, David, S. , MCCLELLAN, William, J. , O'CONNOR, Stephen, J. , PRASAD, Rajnandan, N. , ROCKWAY, Todd, W. , ROSENBERG, Saul, H. , STEIN, Herman, H. , SHEN, Wang , STOUT, David, M. , SULLIVAN, Gerard, M. , AUGERI, David, J.
IPC分类号： C07C233/60 , C07D333/20 , C07C233/58 , C07C233/59 , C07C235/40 , A61K31/19 , A61K31/215 , A61K31/38 , A61K31/16
CPC分类号： C07C235/82 , C07C233/58 , C07C233/59 , C07C233/60 , C07C235/40 , C07C2601/04 , C07D333/20
摘要： The present invention provides a compound of formula (I) or (II) or a pharmaceutically acceptable salt thereof, which is useful for inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.
摘要翻译： 本发明提供式（II）化合物或其药学上可接受的盐，其可用于抑制蛋白质法呢基转移酶和癌基因蛋白Ras的法呢基化，制备本发明化合物的方法除了可用于 这些方法，药物组合物，以及使用这些化合物的方法。
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7.发明公开CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE 失效CYCLOBUTAN-DERIVATE ALS INHIBITOREN DER SQUALEN-SYNTHETASE UND DER PROTEIN-FARNESYLTRANSFERASE。
公开(公告)号：EP0677039A1
公开(公告)日：1995-10-18
申请号：EP94931987.0
申请日：1994-10-20
申请人： Abbott Laboratories
发明人： BAKER, William, R. , ROCKWAY, Todd, W. , DONNER, B., Gregory , SHEN, Wang , ROSENBERG, Saul, H. , FAKHOURY, Stephen, A. , O'CONNOR, Stephen, J. , STOUT, David, M. , FUNG, Anthony, K., L. , GARVEY, David, S. , PRASAD, Rajnandan , SULLIVAN, Gerard, M.
IPC分类号： C12N9 , A61K31 , A61P3 , A61P7 , A61P9 , A61P31 , A61P43 , C07C69 , C07C231 , C07C233 , C07C235 , C07C237 , C07C245 , C07C251 , C07C259 , C07C275 , C07C311 , C07C323 , C07C327 , C07D207 , C07D213 , C07D257 , C07D263 , C07D271 , C07D277 , C07D285 , C07D307 , C07D309 , C07D317 , C07D319 , C07D333
CPC分类号： C07C233/61 , C07C69/74 , C07C233/19 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/62 , C07C233/63 , C07C235/36 , C07C235/40 , C07C237/24 , C07C245/14 , C07C251/42 , C07C259/08 , C07C311/51 , C07C323/40 , C07C323/46 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D309/32 , C07D319/06 , C07D333/58
摘要： The present invention provides a compound of formula (I) processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and a method of treating disorders resulting from an excess of cholesterol or cancer or a fungal infection.
摘要翻译： 本发明提供式（I）化合物，除了可用于这些方法的中间体以外，还可用于制备本发明化合物的方法，药物组合物和治疗由过量胆固醇或癌症引起的病症的方法或 真菌感染。
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公开(公告)号：EP1758592A1
公开(公告)日：2007-03-07
申请号：EP05755148.3
申请日：2005-05-26
申请人： ABBOTT LABORATORIES
IPC分类号： A61K31/635 , A61P35/00
CPC分类号： A61K31/635
摘要： Compositions comprising a cancer drug, a continuous oral dosing schedule with a drug which binds to the colchicine site of tubulin β-subunits, and methods of treating cancer in a pediatric patient using continuous dosing schedules are disclosed.
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公开(公告)号：EP1318978A2
公开(公告)日：2003-06-18
申请号：EP01971244.7
申请日：2001-09-20
申请人： Abbott Laboratories
发明人： MCCLELLAN, William , OOST, Thorsten , BRUNCKO, Milan , WANG, Xilu , AUGERI, David, J. , BAUMEISTER, Steven, A. , DICKMAN, Daniel, A. , DING, Hong , DINGES, Jurgen , FESIK, Stephen, W. , HAJDUK, Philip, J. , KUNZER, Aaron, R. , NETTESHEIM, David, G. , PETROS, Andrew, M. , ROSENBERG, Saul, H. , SHEN, Wang , THOMAS, Sheela, A. , WENDT, Michael, D.
IPC分类号： C07C311/51 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/58 , C07C323/60
CPC分类号： C07D207/404 , C07C311/51 , C07C317/28 , C07C323/12 , C07C323/17 , C07C323/25 , C07C323/30 , C07C323/37 , C07C323/58 , C07C323/60 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/28 , C07C2602/42 , C07C2602/44 , C07C2603/74 , C07D203/10 , C07D205/12 , C07D207/24 , C07D209/08 , C07D209/96 , C07D211/44 , C07D211/70 , C07D211/74 , C07D213/61 , C07D213/70 , C07D213/71 , C07D215/14 , C07D215/227 , C07D215/48 , C07D217/04 , C07D221/20 , C07D231/12 , C07D235/08 , C07D235/26 , C07D241/16 , C07D249/04 , C07D263/56 , C07D263/58 , C07D277/62 , C07D277/64 , C07D295/13 , C07D295/155 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D307/14 , C07D317/54 , C07D333/28 , C07D333/68 , C07D401/06 , C07D401/12 , C07D405/04 , C07D417/12 , C07D451/02
摘要： N-Benzoyl arylsulfonamides having the formula (I) are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.
摘要翻译： 具有式（I）的N-苯甲酰基芳基磺酰胺是BCL-X1抑制剂，可用于促进凋亡。 还公开了BCL-X1抑制组合物和促进哺乳动物细胞凋亡的方法。
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10.发明授权CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE 失效CYCLOBUTAN-DERIVATE ALS INHIBITOREN DER SQUALEN-SYNTHETASE UND DER PROTEIN-FARNESYLTRANSFERASE
公开(公告)号：EP0677039B1
公开(公告)日：1999-03-10
申请号：EP94931987.5
申请日：1994-10-20
申请人： Abbott Laboratories
发明人： BAKER, William, R. , ROCKWAY, Todd, W. , DONNER, B., Gregory , SHEN, Wang , ROSENBERG, Saul, H. , FAKHOURY, Stephen, A. , O'CONNOR, Stephen, J. , STOUT, David, M. , FUNG, Anthony, K., L. , GARVEY, David, S. , PRASAD, Rajnandan , SULLIVAN, Gerard, M.
IPC分类号： C07C233/60 , C07C323/40 , C07D257/04 , A61K31/16 , A61K31/41
CPC分类号： C07C233/61 , C07C69/74 , C07C233/19 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/62 , C07C233/63 , C07C235/36 , C07C235/40 , C07C237/24 , C07C245/14 , C07C251/42 , C07C259/08 , C07C311/51 , C07C323/40 , C07C323/46 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D309/32 , C07D319/06 , C07D333/58
摘要： The present invention provides a compound of formula (I) processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and a method of treating disorders resulting from an excess of cholesterol or cancer or a fungal infection.
摘要翻译： 本发明提供式（I）化合物，除了可用于这些方法的中间体以外，还可用于制备本发明化合物的方法，药物组合物和治疗由过量胆固醇或癌症引起的病症的方法或 真菌感染。
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