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1.发明授权Intermediates for the preparation of retroviral protease inhibiting compounds 失效中间体，用于逆转录病毒蛋白酶抑制化合物的制备
公开(公告)号：EP0727419B1
公开(公告)日：2002-02-27
申请号：EP96106301.3
申请日：1993-12-16
申请人： Abbott Laboratories
发明人： Kempf, Dale J. , Norbeck, Daniel W. , Sham, Hing Leung , Zhao, Chen , Sowin, Thomas J. , Reno, Daniel S. , Haight, Anthony R. , Cooper, Arthur J.
IPC分类号： C07D277/28 , A61K31/425 , C07D277/24 , C07D303/36 , C07D417/12
CPC分类号： C07D413/12 , A61K31/425 , A61K31/427 , A61K31/70 , A61K38/00 , A61K45/06 , C07C33/46 , C07C43/164 , C07C43/1742 , C07C43/2055 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/004 , C07C45/29 , C07C45/567 , C07C45/62 , C07C45/673 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D249/08 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D417/12 , C07K5/06026 , C07K5/06078 , A61K31/00 , A61K2300/00 , C07C49/233 , C07C49/255 , C07C49/215 , C07C49/245 , C07C49/235 , C07C49/223
摘要： A retroviral protease inhibiting compound of formula (A) is disclosed for use in combination with other active pharmaceutical agents for treating a human infected by HIV. Intermediates and processes useful in the manufacture of compounds of formula (A) are also disclosed.
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2.发明公开Processes and intermediates for manufacturing retroviral protease inhibiting compounds 失效Verfahren und Intermediate zur Herstellung von retroviralen Proteasehemmern
公开(公告)号：EP1302468A1
公开(公告)日：2003-04-16
申请号：EP02079949.0
申请日：1993-12-16
申请人： ABBOTT LABORATORIES
发明人： Kempf, Dale J. , Norbeck, Daniel W. , Sham, Hing Leung , Zhao, Chen , Sowin, Thomas J. , Reno, Daniel S. , Haight, Anthony R. , Cooper, Arthur J.
IPC分类号： C07D277/24 , C07D277/28 , C07D303/36 , C07D277/34 , C07D277/42 , C07D417/12 , C07D263/32 , C07D413/12 , C07F5/02 , A61K31/426 , A61P31/18
CPC分类号： C07D413/12 , A61K31/425 , A61K31/427 , A61K31/70 , A61K38/00 , A61K45/06 , C07C33/46 , C07C43/164 , C07C43/1742 , C07C43/2055 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/004 , C07C45/29 , C07C45/567 , C07C45/62 , C07C45/673 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D249/08 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D417/12 , C07K5/06026 , C07K5/06078 , A61K31/00 , A61K2300/00 , C07C49/233 , C07C49/255 , C07C49/215 , C07C49/245 , C07C49/235 , C07C49/223
摘要： A retroviral protease inhibiting compound of formula (A) is disclosed for use in combination with other active pharmaceutical agents for treating a human infected by HIV. Intermediates and processes useful in the manufacture of compounds of formula (A) are also disclosed.
摘要翻译： 公开了用于与用于治疗HIV感染的人的其它活性药剂组合使用的式（A）的逆转录病毒蛋白酶抑制化合物。 还公开了可用于制备式（A）化合物的中间体和方法。
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3.发明公开Processes and intermediates for manufacturing retroviral protease inhibiting compounds 失效方法和中间体逆转录病毒蛋白酶抑制剂的制备中
公开(公告)号：EP1090914A3
公开(公告)日：2001-04-18
申请号：EP00124382.3
申请日：1993-12-16
申请人： ABBOTT LABORATORIES
发明人： Kempf, Dale J. , Norbeck, Daniel W. , Sham, Hing Leung , Zhao, Chen , Sowin, Thomas J. , Reno, Daniel S. , Haight, Anthony R. , Cooper, Arthur J.
IPC分类号： C07D277/24 , C07D277/28 , C07D303/36 , C07D277/34 , C07D277/42 , C07D417/12 , C07D263/32 , C07D413/12 , C07F5/02 , A61K31/426 , A61P31/18
CPC分类号： C07D413/12 , A61K31/425 , A61K31/427 , A61K31/70 , A61K38/00 , A61K45/06 , C07C33/46 , C07C43/164 , C07C43/1742 , C07C43/2055 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/004 , C07C45/29 , C07C45/567 , C07C45/62 , C07C45/673 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D249/08 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D417/12 , C07K5/06026 , C07K5/06078 , A61K31/00 , A61K2300/00 , C07C49/233 , C07C49/255 , C07C49/215 , C07C49/245 , C07C49/235 , C07C49/223
摘要： A retroviral protease inhibiting compound of formula (A) is disclosed for use in combination with other active pharmaceutical agents for treating a human infected by HIV. Intermediates and processes useful in the manufacture of compounds of formula (A) are also disclosed.
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公开(公告)号：EP0727419A3
公开(公告)日：1996-10-30
申请号：EP96106301.3
申请日：1993-12-16
申请人： Abbott Laboratories
发明人： Kempf, Dale J. , Norbeck, Daniel W. , Sham, Hing Leung , Zhao, Chen , Sowin, Thomas J. , Reno, Daniel S. , Haight, Anthony R. , Cooper, Arthur J.
IPC分类号： C07D277/28 , A61K31/425 , C07D277/24 , C07D303/36 , C07D417/12
CPC分类号： C07D413/12 , A61K31/425 , A61K31/427 , A61K31/70 , A61K38/00 , A61K45/06 , C07C33/46 , C07C43/164 , C07C43/1742 , C07C43/2055 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/004 , C07C45/29 , C07C45/567 , C07C45/62 , C07C45/673 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D249/08 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D417/12 , C07K5/06026 , C07K5/06078 , A61K31/00 , A61K2300/00 , C07C49/233 , C07C49/255 , C07C49/215 , C07C49/245 , C07C49/235 , C07C49/223
摘要： A retroviral protease inhibiting compound of formula (A) is disclosed for use in combination with other active pharmaceutical agents for treating a human infected by HIV. Intermediates and processes useful in the manufacture of compounds of formula (A) are also disclosed.
摘要翻译： 公开了式（A）的逆转录病毒蛋白酶抑制化合物与其他活性药物组合用于治疗HIV感染的人。 也公开了用于制造式（A）化合物的中间体和方法。
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公开(公告)号：EP0727419A2
公开(公告)日：1996-08-21
申请号：EP96106301.3
申请日：1993-12-16
申请人： Abbott Laboratories
发明人： Kempf, Dale J. , Norbeck, Daniel W. , Sham, Hing Leung , Zhao, Chen , Sowin, Thomas J. , Reno, Daniel S. , Haight, Anthony R. , Cooper, Arthur J.
IPC分类号： C07D277/28 , A61K31/425 , C07D277/24 , C07D303/36 , C07D417/12
CPC分类号： C07D413/12 , A61K31/425 , A61K31/427 , A61K31/70 , A61K38/00 , A61K45/06 , C07C33/46 , C07C43/164 , C07C43/1742 , C07C43/2055 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/004 , C07C45/29 , C07C45/567 , C07C45/62 , C07C45/673 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D249/08 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D417/12 , C07K5/06026 , C07K5/06078 , A61K31/00 , A61K2300/00 , C07C49/233 , C07C49/255 , C07C49/215 , C07C49/245 , C07C49/235 , C07C49/223
摘要： A retroviral protease inhibiting compound of formula (A) is disclosed for use in combination with other active pharmaceutical agents for treating a human infected by HIV. Intermediates and processes useful in the manufacture of compounds of formula (A) are also disclosed.
摘要翻译： 公开了用于与用于治疗HIV感染的人的其它活性药剂组合使用的式（A）的逆转录病毒蛋白酶抑制化合物。 还公开了可用于制备式（A）化合物的中间体和方法。
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6.发明授权Processes and intermediates for manufacturing retroviral protease inhibiting compounds 失效方法和中间体逆转录病毒蛋白酶抑制剂的制备中
公开(公告)号：EP1302468B1
公开(公告)日：2008-12-17
申请号：EP02079949.0
申请日：1993-12-16
申请人： ABBOTT LABORATORIES
发明人： Kempf, Dale J. , Norbeck, Daniel W. , Sham, Hing Leung , Zhao, Chen , Sowin, Thomas J. , Reno, Daniel S. , Haight, Anthony R. , Cooper, Arthur J.
IPC分类号： C07D277/24 , C07D277/28 , C07D303/36 , C07D277/34 , C07D277/42 , C07D417/12 , C07D263/32 , C07D413/12 , C07F5/02 , A61K31/426 , A61P31/18
CPC分类号： C07D413/12 , A61K31/425 , A61K31/427 , A61K31/70 , A61K38/00 , A61K45/06 , C07C33/46 , C07C43/164 , C07C43/1742 , C07C43/2055 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/004 , C07C45/29 , C07C45/567 , C07C45/62 , C07C45/673 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D249/08 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D417/12 , C07K5/06026 , C07K5/06078 , A61K31/00 , A61K2300/00 , C07C49/233 , C07C49/255 , C07C49/215 , C07C49/245 , C07C49/235 , C07C49/223
摘要： A retroviral protease inhibiting compound of formula (A) is disclosed for use in combination with other active pharmaceutical agents for treating a human infected by HIV. Intermediates and processes useful in the manufacture of compounds of formula (A) are also disclosed.
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公开(公告)号：EP1090914B1
公开(公告)日：2003-01-02
申请号：EP00124382.3
申请日：1993-12-16
申请人： ABBOTT LABORATORIES
发明人： Kempf, Dale J. , Norbeck, Daniel W. , Sham, Hing Leung , Zhao, Chen , Sowin, Thomas J. , Reno, Daniel S. , Haight, Anthony R. , Cooper, Arthur J.
IPC分类号： C07D277/24 , C07D277/28 , C07D303/36 , C07D277/34 , C07D277/42 , C07D417/12 , C07D263/32 , C07D413/12 , C07F5/02 , A61K31/426 , A61P31/18
CPC分类号： C07D413/12 , A61K31/425 , A61K31/427 , A61K31/70 , A61K38/00 , A61K45/06 , C07C33/46 , C07C43/164 , C07C43/1742 , C07C43/2055 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/004 , C07C45/29 , C07C45/567 , C07C45/62 , C07C45/673 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D249/08 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D417/12 , C07K5/06026 , C07K5/06078 , A61K31/00 , A61K2300/00 , C07C49/233 , C07C49/255 , C07C49/215 , C07C49/245 , C07C49/235 , C07C49/223
摘要： A retroviral protease inhibiting compound of formula (A) is disclosed for use in combination with other active pharmaceutical agents for treating a human infected by HIV. Intermediates and processes useful in the manufacture of compounds of formula (A) are also disclosed.
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8.发明公开Processes and intermediates for manufacturing retroviral protease inhibiting compounds 失效方法和中间体逆转录病毒蛋白酶抑制剂的制备中
公开(公告)号：EP1090914A2
公开(公告)日：2001-04-11
申请号：EP00124382.3
申请日：1993-12-16
申请人： ABBOTT LABORATORIES
发明人： Kempf, Dale J. , Norbeck, Daniel W. , Sham, Hing Leung , Zhao, Chen , Sowin, Thomas J. , Reno, Daniel S. , Haight, Anthony R. , Cooper, Arthur J.
IPC分类号： C07D277/24 , C07D277/28 , C07D303/36 , C07D277/34 , C07D277/42 , C07D417/12 , C07D263/32 , C07D413/12 , C07F5/02 , A61K31/426 , A61P31/18
CPC分类号： C07D413/12 , A61K31/425 , A61K31/427 , A61K31/70 , A61K38/00 , A61K45/06 , C07C33/46 , C07C43/164 , C07C43/1742 , C07C43/2055 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/004 , C07C45/29 , C07C45/567 , C07C45/62 , C07C45/673 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C381/00 , C07D213/26 , C07D213/30 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D249/08 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D417/12 , C07K5/06026 , C07K5/06078 , A61K31/00 , A61K2300/00 , C07C49/233 , C07C49/255 , C07C49/215 , C07C49/245 , C07C49/235 , C07C49/223
摘要： A retroviral protease inhibiting compound of formula (A) is disclosed for use in combination with other active pharmaceutical agents for treating a human infected by HIV. Intermediates and processes useful in the manufacture of compounds of formula (A) are also disclosed.
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