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公开(公告)号：EP1646621A2
公开(公告)日：2006-04-19
申请号：EP04777733.9
申请日：2004-07-09
申请人： ABBOTT LABORATORIES
发明人： ZHENG, Guo Zhu , BROWN, Brian, S. , TURNER, Sean, C. , WHITE, Tammie, K. , SCHMIDT, Robert, G. , KOENIG, John, R. , LEE, Chih-Hung
IPC分类号： C07D401/04 , C07D401/12 , C07D487/08 , A61K31/4525 , A61K31/4995 , A61P25/04
CPC分类号： C07D401/04 , C07D487/08
摘要： The present invention relates to compounds of formula (I-VII) (I), or a pharmaceutically acceptable salt or prodrug thereof, in which A, L, R6, R7and R8 are defined herein. The present invention also relates to methods of trating pain using these compounds and pharmaceutical compositions including these compounds.
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2.发明公开FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR 有权CONDENSED AZABICYCLISCHEVERBINDUNGEN作为香草素受体1的抑制剂（VR1）
公开(公告)号：EP1478363A1
公开(公告)日：2004-11-24
申请号：EP03716014.0
申请日：2003-02-11
申请人： Abbott Laboratories
发明人： LEE, Chih-Hung , BAYBURT, Erol, K. , DIDOMENICO, Stanley Jr. , DRIZIN, Irene , GOMTSYAN, Arthur, R. , KOENIG, John R. , PERNER, Richard, J. , SCHMIDT, Robert G. , TURNER, Sean C. , WHITE, Tammie, K. , ZHENG, Guo, Zhu
IPC分类号： A61K31/502 , C07D217/02 , C07D237/28 , C07D217/22 , C07D209/08 , C07D231/56 , A61K31/472 , A61K31/416 , A61K31/404
CPC分类号： C07D249/08 , A61K31/404 , A61K31/416 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D209/08 , C07D217/02 , C07D217/22 , C07D217/24 , C07D217/26 , C07D231/12 , C07D231/56 , C07D233/56 , C07D237/28 , C07D401/12 , C07D405/12
摘要： Compounds of formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.
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3.发明授权FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR 有权CONDENSED AZABICYCLISCHEVERBINDUNGEN作为香草素受体1的抑制剂（VR1）
公开(公告)号：EP1478363B1
公开(公告)日：2009-01-14
申请号：EP03716014.0
申请日：2003-02-11
申请人： ABBOTT LABORATORIES
发明人： LEE, Chih-Hung , BAYBURT, Erol, K. , DIDOMENICO, Stanley Jr. , DRIZIN, Irene , GOMTSYAN, Arthur, R. , KOENIG, John R. , PERNER, Richard, J. , SCHMIDT, Robert G. , TURNER, Sean C. , WHITE, Tammie, K. , ZHENG, Guo, Zhu
IPC分类号： A61K31/502 , C07D217/02 , C07D237/28 , C07D217/22 , C07D209/08 , C07D231/56 , A61K31/472 , A61K31/416 , A61K31/404
CPC分类号： C07D249/08 , A61K31/404 , A61K31/416 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D209/08 , C07D217/02 , C07D217/22 , C07D217/24 , C07D217/26 , C07D231/12 , C07D231/56 , C07D233/56 , C07D237/28 , C07D401/12 , C07D405/12
摘要： Compounds of formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.
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4.发明授权FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR 有权THE VANILLOIDREZEPTORSUBTYP 1（VR1）简明氮杂双环化合物 - 受体禁止
公开(公告)号：EP1660455B1
公开(公告)日：2008-10-15
申请号：EP04780017.2
申请日：2004-08-04
申请人： ABBOTT LABORATORIES
发明人： BAYBURT, Erol, K. , DIDOMENICO, Stanley, Jr. , DRIZIN, Irene , GOMTSYAN, Arthur, R.; , KOENIG, John, R. , PENNER, Richard, J. , SCHMIDT, Robert, G., Jr. , TURNER, Sean, C. , WHITE, Tammie, K. , ZHENG, Guo Zhu
IPC分类号： C07D217/24 , C07D217/02 , C07D237/28 , C07D217/22 , C07D209/08 , C07D231/56 , C07D217/26 , C07D401/12 , C07D405/12 , C07D403/12 , C07D451/02 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/5377
CPC分类号： C07D249/08 , C07D209/08 , C07D217/02 , C07D217/22 , C07D217/24 , C07D217/26 , C07D231/12 , C07D231/56 , C07D233/56 , C07D237/28 , C07D401/12 , C07D405/12
摘要： Compounds of Formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.
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5.发明公开FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR 有权THE VANILLOIDREZEPTORSUBTYP 1（VR1）简明氮杂双环化合物 - 受体禁止
公开(公告)号：EP1660455A1
公开(公告)日：2006-05-31
申请号：EP04780017.2
申请日：2004-08-04
发明人： BAYBURT, Erol, K. , DIDOMENICO, Stanley, Jr. , DRIZIN, Irene , GOMTSYAN, Arthur, R.; , KOENIG, John, R. , PENNER, Richard, J. , SCHMIDT, Robert, G., Jr. , TURNER, Sean, C. , WHITE, Tammie, K. , ZHENG, Guo Zhu
IPC分类号： C07D217/24 , C07D217/02 , C07D237/28 , C07D217/22 , C07D209/08 , C07D231/56 , C07D217/26 , C07D401/12 , C07D405/12 , C07D403/12 , C07D451/02 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/5377
CPC分类号： C07D249/08 , C07D209/08 , C07D217/02 , C07D217/22 , C07D217/24 , C07D217/26 , C07D231/12 , C07D231/56 , C07D233/56 , C07D237/28 , C07D401/12 , C07D405/12
摘要： Compounds of Formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.
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