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    Method for producing 2-substituted-thiazolidine-4-carboxylic acids
    4.
    发明公开
    Method for producing 2-substituted-thiazolidine-4-carboxylic acids 失效
    生产2-取代的噻唑烷-4-羧酸的方法

    公开(公告)号：EP0101052A3

    公开(公告)日：1984-12-27

    申请号：EP83107857

    申请日：1983-08-09

    申请人： AJINOMOTO CO., INC.

    发明人： Yokozeki, Kenzo ,  Kubota, Koji ,  Kamimura, Akira ,  Eguchi, Chikahiko

    IPC分类号： C12P17/14 ,  C07D277/06

    CPC分类号： C07D277/06 ,  C12P17/14

    摘要： A 2-substituted-thiazolldine-4-carboxylic acid is produced in a high yield by holding 2-amino-2-thiazoline-4-carboxylic acid and a carbonyl compound of the formula:
    wherein R, and R 2 are identical or different and each represents a hydrogen atom, a formyl group, a carboxyl group, a substituted or unsubstituted saturated or unsaturated alkyl group, or a substituted or unsubstituted aryl group, in aqueous solution in the presence of an effective amount of an enzyme of a microorganism, said enzyme being capable of converting 2-amino-thiazoline-4-carboxylic acid to L-cysteine, and said microorganism being capable of growing in a medium containing 2-amino-thiazoline-4-carboxylic acid as a nitrogen source and producing said enzyme.

    Method for producing 2-substituted-thiazolidine-4-carboxylic acids
    6.
    发明公开
    Method for producing 2-substituted-thiazolidine-4-carboxylic acids 失效
    Verfahren zur Herstellung von 2-substitutionierter噻唑烷-4-碳。

    公开(公告)号：EP0101052A2

    公开(公告)日：1984-02-22

    申请号：EP83107857.1

    申请日：1983-08-09

    申请人： AJINOMOTO CO., INC.

    发明人： Yokozeki, Kenzo ,  Kubota, Koji ,  Kamimura, Akira ,  Eguchi, Chikahiko

    IPC分类号： C12P17/14 ,  C07D277/06

    CPC分类号： C07D277/06 ,  C12P17/14

    摘要： A 2-substituted-thiazolldine-4-carboxylic acid is produced in a high yield by holding 2-amino-2-thiazoline-4-carboxylic acid and a carbonyl compound of the formula:
    wherein R, and R 2 are identical or different and each represents a hydrogen atom, a formyl group, a carboxyl group, a substituted or unsubstituted saturated or unsaturated alkyl group, or a substituted or unsubstituted aryl group,
    in aqueous solution in the presence of an effective amount of an enzyme of a microorganism, said enzyme being capable of converting 2-amino-thiazoline-4-carboxylic acid to L-cysteine, and said microorganism being capable of growing in a medium containing 2-amino-thiazoline-4-carboxylic acid as a nitrogen source and producing said enzyme.

    摘要翻译： 通过保持2-氨基-2-噻唑啉-4-羧酸和下式的羰基化合物，其中R 1和R 2相同，以高产率制备2-取代的噻唑烷-4-羧酸 或不同的，并且各自表示氢原子，甲酰基，羧基，取代或未取代的饱和或不饱和烷基或取代或未取代的芳基，在有效量的 微生物，所述酶能够将2-氨基 - 噻唑啉-4-羧酸转化为L-半胱氨酸，并且所述微生物能够在含有2-氨基 - 噻唑啉-4-羧酸的培养基中生长，作为氮源，并产生 说酶。

    Use of ethylamine derivatives as antihypertensive agents
    8.
    发明公开
    Use of ethylamine derivatives as antihypertensive agents 失效
    Verwendung vonÄthylamin-Derivaten als antihypertensive Wirkstoffe。

    公开(公告)号：EP0294183A1

    公开(公告)日：1988-12-07

    申请号：EP88305012.2

    申请日：1988-06-01

    申请人： AJINOMOTO CO., INC.

    发明人： Syoji, Masataka ,  Eguchi, Chikahiko ,  Toyota, Kozo ,  Yoshimoto, Ryota ,  Koyama, Yosikatsu ,  Domoto, Hideki ,  Kamimura, Akira

    IPC分类号： C07D211/32 ,  C07D211/22 ,  C07D211/18 ,  C07D285/24 ,  C07D401/06 ,  A61K31/445 ,  A61K31/54

    CPC分类号： C07D401/06 ,  C07D211/32 ,  C07D285/24 ,  C07D409/06

    摘要： Novel ethylamine derivatives of the formula (I) and salts thereof are useful as antihypertensive agents.
    wherein A is a linking group wherein the linkage is formed by a carbon or nitrogen atom; B is an aryl-containing group; C is hydrogen or optionally substituted alkyl, aralkyl or aryl, or C may be bonded to A to form an optionally substituted alkylene bridge; Q is an aryl- or heterocyclic aryl-containing group; X is a linking group wherein the linkage is formed by optionally substituted alkylene having from 2 to 20 carbon atoms and/or one or more hetero atoms selected from nitrogen and sulfur.

    摘要翻译： 新的式（I）乙胺衍生物及其盐可用作抗高血压药。 其中A是连接基，其中连接是由碳或氮原子形成的; B是含芳基的基团; C是氢或任选取代的烷基，芳烷基或芳基，或C可以与A键合以形成任选取代的亚烷基桥; Q是含芳基或杂环芳基的基团; X是连接基团，其中连接是由具有2至20个碳原子的任选取代的亚烷基和/或一个或多个选自氮和硫的杂原子形成的。