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1.发明授权Gene coding for interleukin-2 polypeptide, recombinant DNA carrying said gene, cell lines possessing the recombinant DNA,and method for producing interleukin-2 using said cells 失效多肽白细胞介素2编码基因，含有这种基因的重组DNA，所述使用所述细胞的重组DNA，包括细胞系和方法，用于生产白细胞介素-2
公开(公告)号：EP0091539B2
公开(公告)日：1996-11-27
申请号：EP83101035.0
申请日：1983-02-03
发明人： Taniguchi, Tadatsugu , Muramatsu, Masami , Sugano, Haruo , Matsui, Hiroshi , Kashima, Nobukazu , Hamuro, Junji
CPC分类号： C07K14/55 , C12N15/70 , C12N15/81 , Y10S435/849 , Y10S930/141
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公开(公告)号：EP0118617A3
公开(公告)日：1985-11-13
申请号：EP83112661
申请日：1983-12-15
发明人： Taniguchi, Tadatsugu , Muramatsu, Masami , Sugano, Haruo , Matsui, Hiroshi , Kashima, Nobukazu , Hamuro, Junji
CPC分类号： C07K14/55
摘要： Interleukin-2 polypeptides, which are free from substances produced by human cells, are provided. These interleukin-2 polypeptides are produced by a culture of cells of Escherichia coli, constructed by gene-recombination technique, into which a plasmid comprising the genetic information for the synthesis of human IL-2, has been inserted.
摘要翻译： 提供了不含人类细胞产生的物质的白细胞介素-2多肽。 这些白细胞介素-2多肽是通过基因重组技术构建的大肠杆菌细胞培养物产生的，其中已经插入了包含合成人IL-2的遗传信息的质粒。
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3.发明公开Saccharomyces cerevisiae possessing gene coding for interleukin-2 polypeptide and method for producing interleukin-2 using the yeast 失效酿酒酵母与白介素-2多肽基因的方法和使用所述酵母生产白细胞介素-2的。
公开(公告)号：EP0142268A1
公开(公告)日：1985-05-22
申请号：EP84306934.5
申请日：1984-10-11
摘要： @ There is disolved a cell of Saccharomyces cerevisiae transformed with a recontinant DNA comprising a gene coding for a polypeptide possessing the activity of interieukin-2 and a vector DNA capable of propagating in said cell, the coding sequence of said gene being located at a position downstream of a promoter sequence.
摘要翻译： 有disolved与recontinant DNA包含基因编码的多肽波塞唱白细胞介素-2的活性并能在所述细胞中传播的一个载体DNA转化酿酒酵母的细胞，所述基因的编码序列位于下游的位置处 的启动子序列。
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4.发明公开Gene coding for interleukin-2 polypeptide, recombinant DNA carrying said gene, cell lines possessing the recombinant DNA,and method for producing interleukin-2 using said cells 失效多肽白细胞介素2编码基因，含有这种基因的重组DNA，所述重组DNA包含细胞系和方法，用于生产白细胞介素-2的使用所述细胞。
公开(公告)号：EP0091539A1
公开(公告)日：1983-10-19
申请号：EP83101035.0
申请日：1983-02-03
发明人： Taniguchi, Tadatsugu , Muramatsu, Masami , Sugano, Haruo , Matsui, Hiroshi , Kashima, Nobukazu , Hamuro, Junji
CPC分类号： C07K14/55 , C12N15/70 , C12N15/81 , Y10S435/849 , Y10S930/141
摘要： A gene coded for a polypeptide which possesses interleukin-2 activity is isolated, and connected with a vector DNA which is capable of replicating in a procaryotic or eucaryotic cell at a position downstream of a promoter gene in the vector obtaining a recombinant DNA, with which the cell is transformed to produce interleukin-2.
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公开(公告)号：EP0118617B1
公开(公告)日：1991-08-21
申请号：EP83112661.0
申请日：1983-12-15
发明人： Taniguchi, Tadatsugu , Muramatsu, Masami , Sugano, Haruo , Matsui, Hiroshi , Kashima, Nobukazu , Hamuro, Junji
CPC分类号： C07K14/55
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6.发明授权Gene coding for interleukin-2 polypeptide, recombinant DNA carrying said gene, cell lines possessing the recombinant DNA,and method for producing interleukin-2 using said cells 失效用于INTERLEUKIN-2多肽的基因编码，携带所述基因的重组DNA，重组DNA的细胞系以及使用所述细胞产生白细胞介素-2的方法
公开(公告)号：EP0091539B1
公开(公告)日：1988-07-13
申请号：EP83101035.0
申请日：1983-02-03
发明人： Taniguchi, Tadatsugu , Muramatsu, Masami , Sugano, Haruo , Matsui, Hiroshi , Kashima, Nobukazu , Hamuro, Junji
CPC分类号： C07K14/55 , C12N15/70 , C12N15/81 , Y10S435/849 , Y10S930/141
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公开(公告)号：EP0118617A2
公开(公告)日：1984-09-19
申请号：EP83112661.0
申请日：1983-12-15
发明人： Taniguchi, Tadatsugu , Muramatsu, Masami , Sugano, Haruo , Matsui, Hiroshi , Kashima, Nobukazu , Hamuro, Junji
CPC分类号： C07K14/55
摘要： Interleukin-2 polypeptides, which are free from substances produced by human cells, are provided. These interleukin-2 polypeptides are produced by a culture of cells of Escherichia coli, constructed by gene-recombination technique, into which a plasmid comprising the genetic information for the synthesis of human IL-2, has been inserted.
摘要翻译： 提供了不含人细胞产生的物质的白细胞介素-2多肽。 通过基因重组技术构建的包含用于合成人IL-2的遗传信息的质粒的质粒的培养产生这些白细胞介素-2多肽。
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公开(公告)号：EP0139216A2
公开(公告)日：1985-05-02
申请号：EP84110996.0
申请日：1984-09-14
CPC分类号： C07K14/005 , A61K38/00 , C12N15/70 , C12N2740/14022
摘要： Recombinant plasmids are constructed by inserting a DNA fragment coding for adult T cell leukemia virus antigen peptide into a vector DNA. Microorganisms are transformed with the recombinant plasmid and thereafter cultured to express the peptide. The adult T cell leukemia virus antigen peptide is useful for the detection and diagnosis of adult T cell leukemia.
摘要翻译： 通过将编码成人T细胞白血病病毒抗原肽的DNA片段插入载体DNA构建重组质粒。 用重组质粒转化微生物，然后培养以表达肽。 成人T细胞白血病病毒抗原肽可用于检测和诊断成人T细胞白血病。
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9.发明公开Novel DNA, cloned DNA, recombinant plasmid containing the DNA, microorganism containing the recombinant plasmid and process for their production 失效新型DNA，克隆DNA，包含DNA的重组质粒，含有重组质粒的微生物及其生产方法
公开(公告)号：EP0028033A3
公开(公告)日：1981-08-19
申请号：EP80106685
申请日：1980-10-30
CPC分类号： C07K14/565
摘要： The invention relates to a DNA which codes for a polypeptide with interferon activity, a cloned DNA showing complementarity to human interferon mRNA, a recombinant plasmid containing such DNA, a microorganism containig the recombinant plasmid and a process for producing said DNA, said cloned DNA, said recombinant plasmid and said microorganism.
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10.发明公开Double-stranded DNA which codes for a polypeptide with human fibroblast interferon activity, cloned DNA, recombinant plasmid containing the DNA and microorganism containing the recombinant plasmid 失效双链DNA，其编码具有人成纤维细胞干扰素的活性的多肽，克隆的DNA，含有该DNA和含有该重组质粒的微生物的重组质粒。
公开(公告)号：EP0028033A2
公开(公告)日：1981-05-06
申请号：EP80106685.3
申请日：1980-10-30
CPC分类号： C07K14/565
摘要： The invention relates to a DNA which codes for a polypeptide with interferon activity, a cloned DNA showing complementarity to human interferon mRNA, a recombinant plasmid containing such DNA, a microorganism containig the recombinant plasmid and a process for producing said DNA, said cloned DNA, said recombinant plasmid and said microorganism.
摘要翻译： 本发明涉及一种DNA，其编码与干扰素活性的多肽，表示互补人干扰素mRNA的克隆的DNA，重组质粒含有寻求DNA，含有用于产生所述DNA的重组质粒和处理的微生物，所述克隆的DNA， 所述重组质粒和所述微生物。
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