公开(公告)号：EP1039895A1

公开(公告)日：2000-10-04

申请号：EP98960732.0

申请日：1998-12-04

申请人： ALCON LABORATORIES, INC.

发明人： YANNI, John, M. ,  HELLBERG, Mark, R.

IPC分类号： A61K31/215 ,  A61K31/165 ,  A61K31/19 ,  A61K31/195

CPC分类号： A61K31/215 ,  Y10S514/913

摘要： Compositions of 3-benzoylphenylacetic acid derivatives for treating GLC1A glaucoma and methods for their use are disclosed.

公开(公告)号：EP1126850A1

公开(公告)日：2001-08-29

申请号：EP99957471.8

申请日：1999-10-20

申请人： ALCON LABORATORIES, INC.

发明人： COLLIER, Robert, J., Jr. ,  HELLBERG, Mark, R. ,  KAPIN, Michael, A. ,  BARNES, George, E. ,  CHANDLER, Michael, L.

IPC分类号： A61K31/445

CPC分类号： A61K31/00 ,  A61K31/445 ,  Y10S514/912

摘要： Compositions and methods for treating disorders of the outer retina with glutamate antagonists are disclosed.

公开(公告)号：EP0859769A1

公开(公告)日：1998-08-26

申请号：EP96924562.0

申请日：1996-07-17

申请人： ALCON LABORATORIES, INC.

发明人： HELLBERG, Mark, R. ,  DELGADO, Pete ,  NIXON, Jon, C.

IPC分类号： A61K31 ,  A61P29 ,  A61P43 ,  C07D307 ,  C07D311

CPC分类号： C07D307/79 ,  C07D307/80 ,  C07D311/72 ,  Y10S514/914

摘要： Compounds having anti-inflammatory and anti-oxydant activity are disclosed. The compounds are useful in preventing and treating inflammatory disorders through several mechanisms. Methods of treatment employing these properties of the compounds and corresponding pharmaceutical compositions are disclosed.

公开(公告)号：EP1039895B1

公开(公告)日：2002-06-05

申请号：EP98960732.0

申请日：1998-12-04

申请人： ALCON LABORATORIES, INC.

发明人： YANNI, John, M. ,  HELLBERG, Mark, R.

IPC分类号： A61K31/215 ,  A61K31/165 ,  A61K31/19 ,  A61K31/195 ,  A61P27/06

CPC分类号： A61K31/215 ,  Y10S514/913

摘要： Compositions of 3-benzoylphenylacetic acid derivatives for treating GLC1A glaucoma and methods for their use are disclosed.

公开(公告)号：EP0716600B1

公开(公告)日：2002-04-03

申请号：EP95923733.0

申请日：1995-06-06

申请人： ALCON LABORATORIES, INC.

发明人： YANNI, John, M. ,  GRAFF, Gustav ,  HELLBERG, Mark, R.

IPC分类号： A61K31/165 ,  A61P27/02 ,  A61P29/00

CPC分类号： C07C237/20 ,  A61K31/165 ,  A61K31/215 ,  C07C233/33 ,  C07C323/60

摘要： Novel ester and amide derivatives of 3-benzoylphenylacetic acid are disclosed. The use of these novel derivatives and certain known derivatives in topically administrable compositions for the treatment of ophthalmic inflammatory disorders is also disclosed.

公开(公告)号：EP0968183A2

公开(公告)日：2000-01-05

申请号：EP98911516.7

申请日：1998-03-06

申请人： ALCON LABORATORIES, INC.

发明人： ZINKE, Paul, W. ,  HELLBERG, Mark, R.

IPC分类号： C07C405/00

CPC分类号： C07C405/0033

摘要： 13-thia prostaglandins are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising said prostaglandins.

公开(公告)号：EP0938472A2

公开(公告)日：1999-09-01

申请号：EP97950592.0

申请日：1997-11-07

申请人： ALCON LABORATORIES, INC.

发明人： KLIMKO, Peter, G. ,  HELLBERG, Mark, R. ,  ZINKE, Paul, W.

IPC分类号： A61K31 ,  A61P27 ,  C07C405

CPC分类号： A61K31/5575 ,  C07C405/00

摘要： 15-fluoro substituted analogs of PGF2α and methods of their use in treating glaucoma and ocular hypertension are disclosed.

公开(公告)号：EP0938472B1

公开(公告)日：2001-06-27

申请号：EP97950592.2

申请日：1997-11-07

申请人： ALCON LABORATORIES, INC.

发明人： KLIMKO, Peter, G. ,  HELLBERG, Mark, R. ,  ZINKE, Paul, W.

IPC分类号： C07C405/00

CPC分类号： A61K31/5575 ,  C07C405/00

摘要： 15-fluoro substituted analogs of PGF2α and methods of their use in treating glaucoma and ocular hypertension are disclosed.

公开(公告)号：EP0869794A1

公开(公告)日：1998-10-14

申请号：EP96938819.0

申请日：1996-11-12

申请人： ALCON LABORATORIES, INC.

发明人： SELLIAH, Robert, D. ,  HELLBERG, Mark, R. ,  KLIMKO, Peter, G. ,  SALLEE, Verney, L. ,  ZINKE, Paul, W.

IPC分类号： C07D307 ,  A61K31 ,  A61P27 ,  A61P43 ,  C07D407 ,  C07D493

CPC分类号： C07D307/18 ,  A61K31/5585 ,  C07D307/20 ,  C07D493/04

摘要： Substituted tetrahydrofuran analogs of prostaglandins and methods of their use in treating glaucoma and ocular hypertension are disclosed.

公开(公告)号：EP0842165A1

公开(公告)日：1998-05-20

申请号：EP97917549.0

申请日：1997-03-19

申请人： ALCON LABORATORIES, INC.

发明人： HELLBERG, Mark, R.

IPC分类号： C07D277 ,  A61K31 ,  A61P3 ,  A61P9 ,  A61P21 ,  A61P27 ,  A61P35 ,  A61P37 ,  A61P43 ,  C07D417

CPC分类号： C07D417/04 ,  C07D277/06 ,  C07D417/12

摘要： Compounds useful as cytoprotective agents of formula (I), wherein z = (a) and (b); n = 0-12; m = 0-12; X = nothing, NR1, O, or S(O)¿n'?; provided that when X = NR?1¿, O, or S(O)¿n'?, then m⊃0 and n⊃0; n' = 0-2; R?1¿ = H, C¿1?-C6 alkyl; R = OH or a pharmaceutically acceptable salt thereof, C1-C6 alkoxyl, amino, mono- or dialkylamino where the alkyl has from 1 to 4 carbon atoms, or a radical of an amino acid of the formula: -NH-(CH2)n-CH(R?2)-CO-R3; R2¿ = H, C¿1?-C4 alkyl, optionally substituted by hydroxy, SH, SCH3, or (un)substituted phenyl; and R?3¿ = OH, C¿1?-C6 alkoxyl, amino, or mono- or dialkyl amino where the alkyl has from 1 to 4 carbon atoms. The compounds possess dual activity, containing a phenolic portion selected to have antioxidant or free radical scavenging properties and a thiazolidine-4-carboxylate portion selected for its potential to act as a cysteine prodrug.