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公开(公告)号：EP2291346A2
公开(公告)日：2011-03-09
申请号：EP09747289.8
申请日：2009-05-11
申请人： Allergan, Inc.
发明人： OLD, David, W. , NGO, Vinh, X. , GAC, Todd, S.
IPC分类号： C07C59/72 , C07D333/40 , A61K31/33 , A61P27/06
CPC分类号： C07D333/40 , C07C59/72
摘要： Disclosed herein are compounds represented by a formula: Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
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公开(公告)号：EP2675786B1
公开(公告)日：2018-12-26
申请号：EP12705582.0
申请日：2012-02-13
申请人： ALLERGAN, INC.
发明人： WOODWARD, David, F. , WANG, Jenny, W. , GARST, Michael, E. , BURK, Robert, M. , GAC, Todd, S. , POLOSO, Neil, J.
IPC分类号： C07C405/00 , A61K8/42 , A61Q7/00
CPC分类号： C07C235/34 , A61K8/42 , A61Q7/00 , C07C405/00 , C07C405/0041 , C07C2601/08
摘要： Provided herein, inter alia, are prodrugs of bimatoprost, methods of using the same and compositions including the same.
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公开(公告)号：EP1390036B1
公开(公告)日：2012-03-07
申请号：EP02746356.1
申请日：2002-05-07
申请人： ALLERGAN, INC.
发明人： BURK, Robert, M. , GAC, Todd, S.
IPC分类号： A61K31/5575 , A61P27/06 , C07C405/00
CPC分类号： C07D333/62 , A61K31/381 , A61K31/5575 , C07D333/28 , C07D333/60
摘要： The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; [formula] wherein hatched lines represent the α configuration, a triangle represents the β configuration and a dotted line represents the presence or absence of a double bond; A and B are CH2; D represents a covalent bond or CH2, O, S or NH; X is CO2R, CONR2, CH2OR, P (O)(OR)2, CONRSO2R SONR2or [formula]
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公开(公告)号：EP2044041A2
公开(公告)日：2009-04-08
申请号：EP07762032.6
申请日：2007-05-09
申请人： ALLERGAN, INC.
发明人： BURK, Robert, M. , OLD, David, W. , GAC, Todd, S.
IPC分类号： C07D275/06 , C07D471/06 , C07D417/12 , C07D417/14 , A61K31/425 , A61P9/12
CPC分类号： C07D417/12 , C07D275/06 , C07D417/06 , C07D417/14
摘要： Disclosed herein is a compound having a structure (I) or a pharmaceutically acceptable salt thereof, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
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公开(公告)号：EP2675786A1
公开(公告)日：2013-12-25
申请号：EP12705582.0
申请日：2012-02-13
申请人： Allergan, Inc.
发明人： WOODWARD, David, F. , WANG, Jenny, W. , GARST, Michael, E. , BURK, Robert, M. , GAC, Todd, S. , POLOSO, Neil, J.
IPC分类号： C07C405/00 , A61K8/42 , A61Q7/00
CPC分类号： C07C235/34 , A61K8/42 , A61Q7/00 , C07C405/00 , C07C405/0041 , C07C2601/08
摘要： Provided herein, inter alia, are prodrugs of bimatoprost, methods of using the same and compositions including the same.
摘要翻译： 本文提供了尤其是比马前列素的前药，使用它们的方法和包含它们的组合物。
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6.发明授权
公开(公告)号：EP1846354B1
公开(公告)日：2010-04-28
申请号：EP06717964.8
申请日：2006-01-10
申请人： ALLERGAN, INC.
发明人： OLD, David, W. , GAC, Todd, S. , NGO, Vinh, X.
IPC分类号： C07C59/68 , C07C59/90 , C07C69/02 , C07C69/52 , A61P27/06 , A61K31/192 , A61K31/222
CPC分类号： C07C405/00 , A61K31/192 , A61K31/216 , A61K31/222 , C07C59/72 , C07C59/74 , C07C59/90 , C07C69/736 , C07C69/738 , C07C2601/08
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7.发明公开
公开(公告)号：EP1846354A2
公开(公告)日：2007-10-24
申请号：EP06717964.8
申请日：2006-01-10
申请人： ALLERGAN, INC.
发明人： OLD, David, W. , GAC, Todd, S. , NGO, Vinh, X.
IPC分类号： C07C59/68 , C07C59/90 , C07C69/02 , C07C69/52 , A61P27/06 , A61K31/192 , A61K31/222
CPC分类号： C07C405/00 , A61K31/192 , A61K31/216 , A61K31/222 , C07C59/72 , C07C59/74 , C07C59/90 , C07C69/736 , C07C69/738 , C07C2601/08
摘要： The invention relates to the use of substituted cyclopentanes or cyclopentanones as ocular hypotensives. New Compounds are also provided.
摘要翻译： 新的化合物，和治疗方法，组合物和药剂与其相关的是在光盘游离缺失。
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公开(公告)号：EP1805139A2
公开(公告)日：2007-07-11
申请号：EP05817142.2
申请日：2005-10-24
申请人： ALLERGAN, INC.
发明人： IM, Wha, Bin , DONDE, Yariv , HOLOBOSKI, Mark , OLD, David, W. , KEDZIE, Karen, M. , GIL, Daniel, W. , DONELLO, John, E. , BURK, Robert, M. , GAC, Todd, S.
IPC分类号： C07C405/00 , A61K31/557 , A61K47/48
CPC分类号： C07C405/00 , A61K47/549 , A61K47/64
摘要： A compound comprising a prodrug of a prostaglandin EP4 agonist, wherein said prodrug is an ester, ether, or amide of a carbohydrate; or said prodrug is an ester, ether, or amide of an amino acid is disclosed herein. Maintenance of the colonic mucosal barrier by method comprising administering a therapeutically effective amount of a prostaglandin EP4 agonist to a colon of a mammal is also disclosed herein. Dosage forms, medicaments, and compositions, related thereto are also disclosed.
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公开(公告)号：EP1390036A1
公开(公告)日：2004-02-25
申请号：EP02746356.1
申请日：2002-05-07
申请人： Allergan, Inc.
发明人： BURK, Robert, M. , GAC, Todd, S.
IPC分类号： A61K31/5575 , A61P27/06 , C07C405/00
CPC分类号： C07D333/62 , A61K31/381 , A61K31/5575 , C07D333/28 , C07D333/60
摘要： The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; [formula] wherein hatched lines represent the α configuration, a triangle represents the β configuration and a dotted line represents the presence or absence of a double bond; A and B are CH2; D represents a covalent bond or CH2, O, S or NH; X is CO2R, CONR2, CH2OR, P (O)(OR)2, CONRSO2R SONR2or [formula]
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