公开(公告)号：EP2964154A4

公开(公告)日：2016-08-17

申请号：EP14759739

申请日：2014-03-07

申请人： ALLOSOURCE

发明人： SHI YALING

IPC分类号： A61F2/28 ,  A61K35/32 ,  A61L27/36 ,  A61P19/08

CPC分类号： A61L27/3608 ,  A61K35/32 ,  A61L27/3834 ,  A61L2430/02

公开(公告)号：EP2967874A4

公开(公告)日：2016-11-16

申请号：EP14767334

申请日：2014-03-13

申请人： ALLOSOURCE

发明人： SHI YALING ,  BARRETT CAROLYN

IPC分类号： A61F2/28

CPC分类号： A61F2/30756 ,  A61F2/28 ,  A61F2/3094 ,  A61F2002/30759 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/30784 ,  A61F2002/30827 ,  A61F2002/3096 ,  A61F2002/3097 ,  A61L27/3612 ,  A61L27/3804 ,  A61L27/56 ,  A61L2430/24

摘要： Osteochondral graft composition comprising a cartilage component and a bone component, and further comprising one or more perforations in the bone component and/or the cartilage component, are provided. Methods of manufacturing and using osteochondral graft compositions comprising one or more perforations in the bone component and/or the cartilage component are also provided.

公开(公告)号：EP2919794A4

公开(公告)日：2016-05-25

申请号：EP13854322

申请日：2013-11-15

申请人： ALLOSOURCE

发明人： SHI YALING ,  BARRETT CAROLYN

IPC分类号： A61K35/32

CPC分类号： A61K35/32 ,  A61L24/0005 ,  A61L2430/06

摘要： Compositions comprising a plurality of cartilage particles from a human adult cadaveric donor, wherein the cartilage particles comprise viable chondrocytes, and a biocompatible carrier are provided. Methods of manufacturing cartilage compositions comprising a plurality of cartilage particles from a human adult cadaveric donor are also provided.

公开(公告)号：EP2958523A4

公开(公告)日：2016-11-30

申请号：EP14754909

申请日：2014-02-21

申请人： ALLOSOURCE

发明人： BARRETT CAROLYN ,  SHI YALING

IPC分类号： A61K35/32 ,  A61P19/04 ,  C12N5/077

CPC分类号： A61F2/30756 ,  A61F2002/30113 ,  A61F2002/30153 ,  A61F2002/30154 ,  A61F2002/30759 ,  A61F2002/30784 ,  A61F2002/3097 ,  A61F2240/002 ,  A61F2310/00359 ,  A61F2310/00371 ,  A61L27/3608 ,  A61L27/3612

摘要： Compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles and a biocompatible carrier are provided. Methods of manufacturing cartilage compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles are also provided.

公开(公告)号：EP2970882A4

公开(公告)日：2016-10-26

申请号：EP14771001

申请日：2014-03-12

申请人： ALLOSOURCE

发明人： SHI YALING ,  DITTMAN BRIAN ,  ATKINSON BRENT ,  STILWELL REGINALD L

IPC分类号： A61L27/24 ,  A61L27/36 ,  A61L27/38 ,  C12N5/00 ,  C12N5/02 ,  C12N5/0775

CPC分类号： A61L27/60 ,  A61K35/28 ,  A61L27/24 ,  A61L27/3604 ,  A61L27/362 ,  A61L27/3641 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/3834 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2300/64 ,  A61L2430/34 ,  A61L2430/40 ,  C12N5/0667 ,  C12N2533/92

摘要： The present invention provides compositions for treating soft tissue injuries comprising a collagen matrix and mesenchymal stem cells adhered to the collagen matrix. Methods of making and using compositions comprising a collagen matrix and mesenchymal stem cells adhered to the collagen matrix are also provided.

公开(公告)号：EP2954044A4

公开(公告)日：2016-09-28

申请号：EP13895259

申请日：2013-10-07

申请人： ALLOSOURCE

发明人： BOGDANSKY SIMON ,  SHI YALING ,  ATKINSON BRENT

IPC分类号： C12N5/00 ,  A61L27/36 ,  A61L27/38 ,  C12N5/02 ,  C12N5/074

CPC分类号： C12N5/0667 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/3834 ,  A61L27/3852 ,  A61L2430/06 ,  C12N2502/1311 ,  C12N2502/1317

公开(公告)号：EP2358404A4

公开(公告)日：2012-08-15

申请号：EP09828080

申请日：2009-11-16

申请人： ALLOSOURCE

发明人： SHI YALING

IPC分类号： A61L27/12 ,  A61K47/02 ,  A61L27/38 ,  C12N5/0775

CPC分类号： A61L27/3834 ,  A01N1/021 ,  A61K35/12 ,  A61K35/38 ,  A61L27/3608 ,  A61L27/3847 ,  A61L27/3895 ,  A61L27/54 ,  A61L2300/406 ,  A61L2430/02 ,  C12N5/0662 ,  C12N5/0667 ,  C12N2509/00 ,  C12N2533/18 ,  C12N2533/90

摘要： There is disclosed a method of combining mesenchymal stem cells (MSCs) with a bone substrate. In an embodiment, the method includes obtaining tissue having MSCs together with unwanted cells. The tissue is digested to form a cell suspension having MSCs and unwanted cells. The cell suspension is added to the substrate. The substrate is cultured to allow the MSCs to adhere. The substrate is rinsed to remove unwanted cells. In various embodiments, the tissue is adipose issue, muscle tissue, or bone marrow tissue. In an embodiment, there is disclosed an allograft product including a combination of MSCs with a bone substrate in which the combination is manufactured by culturing MSCs disposed on the substrate for a period of time to allow the MSCs to adhere to the substrate, and then rinsing the substrate to remove unwanted cells from the substrate. Other embodiments are also disclosed.