公开(公告)号：EP1414978A1

公开(公告)日：2004-05-06

申请号：EP02767285.6

申请日：2002-07-31

申请人： ALTANA Pharma AG

发明人： HAUSER, Hansjörg ,  MÜLLER, Peter, P. ,  SCHÄFER, Klaus, P. ,  STEINHILBER, Wolfram

IPC分类号： C12N15/67 ,  C12N15/64 ,  C12N15/62 ,  C12N5/10

CPC分类号： C12N15/63 ,  C07K2319/00 ,  C07K2319/60 ,  C12N15/64 ,  C12N15/67

摘要： This invention describes a novel recombinant gene expression method based on a novel recombinant gene expression vector, comprising in the following order a promoter sequence, a gene of interest, a translational stop signal and translationally linked to said gene of interest a selectable marker gene.

公开(公告)号：EP1379641A2

公开(公告)日：2004-01-14

申请号：EP01986897.5

申请日：2001-12-19

申请人： ALTANA Pharma AG

发明人： MÜHLDORFER, Ingeborg ,  SCHÄFER, Klaus, P.

IPC分类号： C12N15/00

CPC分类号： C12N15/70

摘要： Described is a novel process for the production of at least one protein of interest by secretion of the protein of interest from a pro- or eukaryotic host cell in a compartment system, which host cell is stably expressing a secretion system and capable of heterologous secretion of the protein of interest and which compartment system has at least a first and a second compartment and wherein the host cell is located in the first compartment and wherein the first and second compartment are separated from each other by a barrier, wherein the barrier is permeable for the secreted protein of interest, but not permeable for the host cell.

公开(公告)号：EP1173194B1

公开(公告)日：2004-06-16

申请号：EP00912431.4

申请日：2000-01-18

申请人： ALTANA Pharma AG

发明人： MELCHERS, Klaus ,  SCHÄFER, Klaus, P. ,  STEINHILBER, Wolfram ,  WHITSETT, Jeffrey, A. ,  LEVINE, Ann, Marie ,  KORFHAGEN, Thomas, R.

IPC分类号： A61K38/17 ,  A61P11/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12

CPC分类号： C07K14/785 ,  A61K38/00 ,  A61K38/1709 ,  Y10S514/885

摘要： Recombinant surfactant protein A and medicament compositions based thereon are useful for the prevention or treatment of pulmonary infection and inflammation.

公开(公告)号：EP1379641B1

公开(公告)日：2005-06-29

申请号：EP01986897.5

申请日：2001-12-19

申请人： ALTANA Pharma AG

发明人： MÜHLDORFER, Ingeborg ,  SCHÄFER, Klaus, P.

IPC分类号： C12N15/00

CPC分类号： C12N15/70

摘要： Described is a novel process for the production of at least one protein of interest by secretion of the protein of interest from a pro- or eukaryotic host cell in a compartment system, which host cell is stably expressing a secretion system and capable of heterologous secretion of the protein of interest and which compartment system has at least a first and a second compartment and wherein the host cell is located in the first compartment and wherein the first and second compartment are separated from each other by a barrier, wherein the barrier is permeable for the secreted protein of interest, but not permeable for the host cell.

公开(公告)号：EP0764172B1

公开(公告)日：2004-09-01

申请号：EP95920906.5

申请日：1995-05-27

申请人： ALTANA Pharma AG

发明人： NAVE, Rüdiger ,  ULRICH, Wolf-Rüdiger ,  STURM, Ernst ,  KRÜGER, Uwe ,  HÄFNER, Dietrich ,  SCHÄFER, Klaus, P. ,  MELCHERS, Klaus

IPC分类号： C07K14/785 ,  A61K38/17

CPC分类号： C07K14/785 ,  A61K38/00

摘要： The disclosure concerns novel polypeptides of formula (I) with lung activity properties. These polypeptides can be produced in large quantities and in highly pure form and are as effective as natural lung surfactants. They can be used in the production of pharmaceutical composition for the treatment of respiratory distress syndrome in premature babies and adults. In said formula (I): A represents H or Phe, B represents Phe or Trp, and C represents Ile, Leu or Ser.