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公开(公告)号：EP1853251A4
公开(公告)日：2010-01-13
申请号：EP06735282
申请日：2006-02-16
发明人： BAKER STEPHEN J , AKAMA TSUTOMU , BELLINGER-KAWAHARA CAROLYN , HERNANDEZ VINCENT S , HOLD KARIN M , LEYDEN JAMES J , MAPLES KIRK R , PLATTNER JACOB J , SANDERS VIRGINIA , ZHANG YONG-KANG
CPC分类号： C07F5/025 , A61K9/0012 , A61K31/69 , C07F5/02 , C07F5/027
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公开(公告)号：EP2069370A4
公开(公告)日：2011-05-04
申请号：EP07868837
申请日：2007-11-21
发明人： AKAMA TSUTOMU , BAKER STEPHEN J , HERNANDEZ VINCENT S , PLATTNER JACOB J , ZHANG YONG-KANG , ZHOU HUCHEN
IPC分类号： C07F9/02
CPC分类号： C07F5/025
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3.发明授权Boron-containing small molecules as anti-inflammatory agents 有权BoronhaltigeKleinmolekülealsentzündungshemmendeWirkstoffe
公开(公告)号：EP2564857B1
公开(公告)日：2017-05-03
申请号：EP12178640
申请日：2009-03-05
发明人： AKAMA TSUTOMU , ZHANG YONG-KANG , DING CHARLES Z , PLATTNER JACOB J , MAPLES KIRK R , FREUND YVONNE , SANDERS VIRGINIA , XIA YI , BAKER STEPHEN J , NIEMANN JAMES A , LU XIAOSONG , SALES MARCELO , SHARMA RASHMI , SINGH RAJESHWAR , JACOBS ROBERT , CHEN DAITAO , ALLEY MICHAEL RICHARD KEVIN
摘要： Compounds and methods of treating anti-inflammatory conditions are disclosed. The compounds are benzoxaboroles and in particular are 5-phenoxy-1-hydroxy-2,1-benzoxaboroles and 5-pyridin-2-yloxy-1-hydroxy-2,1-benzoxaboroles.
摘要翻译： 公开了治疗抗炎症的化合物和方法。 这些化合物是苯并氧杂硼杂环戊烯，特别是5-苯氧基-1-羟基-2,1-苯并氧杂硼杂环戊烯和5-吡啶-2-基氧基-1-羟基-2,1-苯并氧杂硼杂环戊烯。
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4.发明公开
公开(公告)号：EP1638578A4
公开(公告)日：2009-04-01
申请号：EP04785938
申请日：2004-06-15
发明人： LEE VING , PLATTNER JACOB J , BENKOVIC STEPHEN J , BAKER STEPHEN J , MAPLES KIRK R , BELLINGER-KAWAHARA CAROLYN , AKAMA TSUTOMU , ZHANG YONG-KANG , SINGH RAJESHWAR , SAURO VITTORIO A
IPC分类号： C07F5/02 , A61K20060101 , A61K31/498 , A61K31/53 , A61K31/69 , A61P31/04 , C07D471/02 , C07D487/02
CPC分类号： C07F5/025
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公开(公告)号：EP2164331A4
公开(公告)日：2011-09-07
申请号：EP08825921
申请日：2008-06-19
发明人： BAKER STEPHEN J , HERNANDEZ VINCENT S , SHARMA RASHMI , NIEMAN JAMES A , AKAMA TSUTOMU , ZHANG YONG-KANG , PLATTNER JACOB J , ALLEY MICHAEL RICHARD KEVIN , SINGH RAJESHWAR , PHILLIPS JAMES G , XIA YI , ZHOU HUCHEN , KERAMANE EL MEHDI , MOHAMMAD RAHIM , HA MINH , LU XIASONG
摘要： This invention provides, among other things, novel oxaboroles which are monosubstituted at the 3-, 6-, or 7-position, or disubstituted at the 3-/6- or 3-/7- positions, which are useful for treating bacterial infections, pharmaceutical compositions containing such oxaboroles, as well as combinations of these oxaboroles with at least one additional therapeutically effective agent.
摘要翻译： 本发明尤其提供了在3-，6-或7-位单取代的或在3- / 6-或3- / 7-位双取代的新的恶唑烷，其可用于治疗细菌感染 ，含有这种恶唑烷的药物组合物，以及这些恶唑烷与至少一种另外的治疗有效药剂的组合。
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公开(公告)号：EP1988779A4
公开(公告)日：2010-12-22
申请号：EP07757149
申请日：2007-02-16
发明人： BAKER STEPHEN J , SANDERS VIRGINIA , AKAMA TSUTOMU , BELLINGER-KAWAHARA CAROLYN , FREUND YVONNE , MAPLES KIRK R , PLATTNER JACOB J , ZHANG YONG-KANG , ZHOU HUCHEN , HERNANDEZ VINCENT S
摘要： Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.
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公开(公告)号：EP2187893A4
公开(公告)日：2012-02-22
申请号：EP09700012
申请日：2009-03-05
发明人： AKAMA TSUTOMU , ZHANG YONG-KANG , DING CHARLES Z , PLATTNER JACOB J , MAPLES KIRK R , FREUND YVONNE , SANDERS VIRGINIA , XIA YI , BAKER STEPHEN J , NIEMANN JAMES A , LU XIAOSONG , SALES MARCELO , SHARMA RASHMI , SINGH RAJESHWAR , JACOBS ROBERT , CHEN DAITAO , ALLEY MICHAEL RICHARD KEVIN
CPC分类号： C07F5/025
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公开(公告)号：EP1976536A4
公开(公告)日：2011-03-02
申请号：EP06801794
申请日：2006-08-16
发明人： BAKER STEPHEN J , AKAMA TSUTOMU , ALLEY MICHAEL RICHARD KEVIN , BENKOVIC STEPHEN J , DIPIERRO MICHAEL , HERNANDEZ VINCENT S , HOLD KARIN M , KENNEDY ISAAC , LIKHOTVORIK IGOR , MAO WEIMIN , MAPLES KIRK R , PLATTNER JACOB J , ROCK FERNANDO , SANDERS VIRGINIA , STEMPHOSKI AARON M , YIANNIKOUROS GEORGE PETROS , ZEGAR SIEAD , ZHANG YONG-KANG , ZHOU HUCHEN
CPC分类号： C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00
摘要： This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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9.发明公开HYDROLYTICALLY-RESISTANT BORON-CONTAINING THERAPEUTICS AND METHODS OF USE 审中-公开抗水解，使用硼THERAPEUTICS方法
公开(公告)号：EP2015757A4
公开(公告)日：2011-01-26
申请号：EP07761776
申请日：2007-05-02
发明人： LEE VING , PLATTNER JACOB J , BENKOVIC STEPHEN J , BAKER STEPHEN J , MAPLES KIRK R , BELLINGER-KAWAHARA CAROLYN , AKAMA TSUTOMU , ZHANG YONG-KANG , SINGH RAJESHWAR , SAURO VITTORIO A
CPC分类号： C07F5/025
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