公开(公告)号：EP0705098A1

公开(公告)日：1996-04-10

申请号：EP94917468.0

申请日：1994-05-23

申请人： APEX BIOSCIENCE, INC. ,  DUKE UNIVERSITY ,  NORTH CAROLINA STATE UNIVERSITY

发明人： DEWHIRST, Mark W. ,  MEYER, Robert E. ,  BONAVENTURA, Joseph ,  DeANGELO, Joseph

IPC分类号： A61N5 ,  A61F7 ,  A61K31 ,  A61K38 ,  A61K41 ,  A61K45 ,  A61P35 ,  A61P43

CPC分类号： A61K41/0052 ,  A61K31/00 ,  A61K31/195 ,  A61K31/198 ,  A61K31/4045 ,  A61K38/42 ,  Y10S514/832 ,  Y10S514/833 ,  Y10S514/929 ,  Y10S514/93 ,  A61K2300/00

摘要： The present invention is directed to the use of an inhibitor of NO activity, such as a nitric oxide scavenger or an NO synthase inhibitor, as an antitumor therapy to reduce tumor blood flow and oxygenation. The invention is also directed to administration of a nitric oxide scavenger or a nitric oxide synthase inhibitor to enhance the effectiveness of tumor therapy with hypoxic or acidic chemotherapeutic agents or hyperthermia. The invention is also directed to the administration of a nitric oxide synthase substrate to a subject previously administered a nitric oxide synthase inhibitor, in order to selectively inhibit tumor perfusion. In a specific example, administration of cell free hemoglobin, a nitric oxide scavenger, in conjunction with mitomycin C, a hypoxic cytotoxin, results in a significant delay in tumor growth of a human tumor xenograft in a mouse compared to mitomycin C alone. In another example, the administration of an inhibitor of nitric oxide synthase followed by the administration of a substrate of the enzyme causes a specific irreversible reduction of tumor blood flow, while normal blood flow is restored.

公开(公告)号：EP2729175A1

公开(公告)日：2014-05-14

申请号：EP12810688.7

申请日：2012-07-09

申请人： Duke University ,  Immunolight, LLC

发明人： BOURKE, Frederic, A. ,  WALDER, Harold ,  FATHI, Zakaryae ,  THERIEN, Michael J. ,  DEWHIRST, Mark W. ,  STANTON, Ian Nicholas ,  AYRES, Jennifer, Ann ,  FELS, Diane, Renee ,  HERBERT, Joseph, A.

IPC分类号： A61K41/00

CPC分类号： A61N5/062 ,  A61K41/0085 ,  A61N5/0622 ,  A61N5/1077 ,  A61N2005/0661 ,  A61N2005/1091 ,  A61N2005/1098

摘要： A system and method for light stimulation within a medium. The system has a reduced-voltage x-ray source configured to generate x-rays from a peak applied cathode voltage at or below 105 kVp, and a plurality of energy-emitting particles in the medium which, upon radiation from the x-ray source, radiate at a first lower energy than the x-ray source to interact with at least one photoactivatable agent in the medium. The method introduces the plurality of energy-emitting particles into the medium, radiates the energy-emitting particles in the medium with x-rays generated from a peak applied cathode voltage at or below 105 kVp; and emits a lower energy than the x-ray source to interact with the medium or with at least one photoactivatable agent in the medium.