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28 条记录 (耗时 0.033 秒)

    TUMOR IMAGING USING PHOTON-EMITTING PHOSPHORS HAVING THERAPEUTIC PROPERTIES
    6.
    发明公开
    TUMOR IMAGING USING PHOTON-EMITTING PHOSPHORS HAVING THERAPEUTIC PROPERTIES 审中-公开
    TUMORBILDGEBUNG MIT PHOTONENEMITTIERENDEN LEUCHTSTOFFEN MIT THERAPEUTISCHEN EIGENSCHAFTEN

    公开(公告)号：EP3134122A1

    公开(公告)日：2017-03-01

    申请号：EP15783728.7

    申请日：2015-04-22

    申请人： Immunolight, LLC. ,  Duke University ,  North Carolina State University

    发明人： WALDER, Harold ,  BOURKE, Frederic, A. ,  FATHI, Zakaryae ,  BEYER, Wayne, F. ,  DEWHIRST, Mark, W. ,  OLDHAM, Mark ,  ADAMSON, Justus ,  NOLAN, Michael

    IPC分类号： A61K41/00 ,  A61N5/06 ,  A61N5/10

    CPC分类号： A61N5/062 ,  A61K41/0042 ,  A61K41/0057 ,  A61K49/0423 ,  A61N5/1071 ,  A61N2005/1089 ,  A61N2005/1091 ,  A61N2005/1098

    摘要： A system and method for imaging or treating a disease in a human or animal body. The system provides to the human or animal body a pharmaceutical carrier including one or more phosphors which are capable of emitting ultraviolet or visible light into the body and which provide x- ray contrast. The system includes one or more devices which infuse a diseased site with a photoactivatable drug and the pharmaceutical carrier, an initiation energy source comprising an x-ray or high energy source which irradiates the diseased site with at least one of x-rays, gamma rays, or electrons to thereby initiate emission of said ultraviolet or visible light into the body, and a processor programmed to at least one of 1) produce images of the diseased site or 2) control a dose of said x- rays, gamma rays, or electrons to the diseased site for production of said ultraviolet or visible light at the diseased site to activate the photoactivatable drug.

    摘要翻译： 介质内光刺激的系统和方法。 该系统具有被配置为从等于或低于200kVp的施加阴极施加电压产生X射线的降低电压x射线源，以及介质中的多个能量转换粒子，其在来自X射线源的辐射 以比x射线源低的能量辐射以与介质中的至少一种可光活化剂相互作用。 该方法将多个能量转换粒子引入到介质中，用从200kVp以下的施加阴极电压产生的x射线照射介质中的能量转换粒子; 并且发射比x射线源更低的能量以与介质或介质中的至少一种可光活化剂相互作用。

    NON-INVASIVE SYSTEMS AND METHODS FOR SELECTIVE ACTIVATION OF PHOTOREACTIVE RESPONSES
    8.
    发明公开
    NON-INVASIVE SYSTEMS AND METHODS FOR SELECTIVE ACTIVATION OF PHOTOREACTIVE RESPONSES 审中-公开
    用于选择性激活光反应的非侵入系统和方法

    公开(公告)号：EP3183037A1

    公开(公告)日：2017-06-28

    申请号：EP15833297.3

    申请日：2015-08-17

    申请人： Immunolight, LLC.

    发明人： BOURKE, Federic, A., Jr. ,  FATHI, Zakaryae ,  WALDER, Harold

    IPC分类号： A61N5/06 ,  A61N5/067 ,  A61N5/08

    CPC分类号： A61N5/062 ,  A61B18/18 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61N1/40 ,  A61N5/02 ,  A61N5/0601 ,  A61N5/0616 ,  A61N5/0618 ,  A61N5/0622 ,  A61N5/0624 ,  A61N5/0625 ,  A61N5/10 ,  A61N2005/0612 ,  A61N2005/0659 ,  A61N2005/0661 ,  A61N2005/0663 ,  A61N2005/067 ,  A61N2005/1089

    摘要： Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

    摘要翻译： 用于修饰介导或与生物活性相关的靶结构的产品，组合物，系统和方法，所述生物活性包括治疗由靶结构介导的或与其相关的病症，病症或疾病，如病毒，细胞，亚细胞结构 或细胞外结构。 所述方法可以通过向受试者施用引发能量以非侵入方式原位进行，从而直接或经由调节剂对靶结构产生作用或改变。 所述方法可以进一步通过原位向受试者施加引发能量以直接或经由能量调节剂，任选地在一种或多种等离子体活性剂存在下激活药剂，从而产生对或改变为 目标结构。 包含配制或配置的产品或组合物的试剂盒以及用于实践这些方法的系统。