公开(公告)号：EP1531716A4

公开(公告)日：2007-06-20

申请号：EP03734487

申请日：2003-06-06

申请人： ATHERSYS INC

发明人： JACKSON PAUL DAVID ,  TING ANTHONY EUGENE ,  FABER PIETER W

IPC分类号： G01N33/50 ,  G01N33/53 ,  A61B20060101 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61P9/00 ,  A61P9/10 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07H21/04 ,  C12N9/64 ,  C12N15/00 ,  C12N15/09 ,  C12Q1/00 ,  C12Q1/02 ,  C12Q1/37 ,  C12Q1/68 ,  G01N33/573 ,  G01N33/574

CPC分类号： G01N33/5011 ,  C12N9/6489 ,  C12Q1/37 ,  G01N33/5088 ,  G01N2333/8146 ,  G01N2500/00

公开(公告)号：EP1594446A4

公开(公告)日：2007-05-23

申请号：EP03781691

申请日：2003-10-28

申请人： ATHERSYS INC

发明人： EKEMA GEORGE MBELLA ,  FABER PIETER W ,  FAGA BENJAMIN PHILIP ,  FOUST GREGORY B ,  HARRINGTON JOHN JOSEPH ,  JACKSON PAUL DAVID ,  MAYS ROBERT W

IPC分类号： C07K14/47 ,  A61K38/00 ,  C07H21/04 ,  C07K14/705 ,  C12N5/00 ,  C12N15/00 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/53 ,  G01N33/68

CPC分类号： G01N33/5044 ,  A61K38/00 ,  C07H21/04 ,  C07K14/705 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5091 ,  G01N33/6872 ,  G01N2500/10

摘要： The current disclosure provide a novel human calcium sensing receptor named CaR2 and the nucleotide sequence that encodes the receptor. The disclosure further provides antibodies specific for CaR2. Also disclosed are methods of identifying modulators of the receptor and methods of using the identified modulators to treat calcium receptor mediated conditions.

公开(公告)号：EP1451295A4

公开(公告)日：2005-03-09

申请号：EP02780573

申请日：2002-11-04

申请人： ATHERSYS INC

发明人： HARRINGTON JOHN JOSEPH ,  JACKSON PAUL DAVID ,  JIANG LI

IPC分类号： C12N20060101 ,  C12N5/00 ,  C12N5/06 ,  C12N15/63 ,  C12N15/74 ,  C12N15/85 ,  C12N15/867 ,  C12N15/87

CPC分类号： C12N15/86 ,  A01K2217/075 ,  A01K2267/03 ,  C12N2740/10043 ,  C12N2800/60 ,  C12N2800/90 ,  C12N2840/203 ,  C12N2840/206 ,  C12N2840/44 ,  C12N2840/445

摘要： The present invention is in the fields of molecular biology, cell biology, and genetics. The invention is directed generally to mutating genes in cells in vitro and in multi-cellular organisms. The invention encompasses methods for mutating genes in cells using polynucleotides that act as insertional mutagens. Such methods are used to achieve mutation of a single gene to achieve a desired phenotype as well as mutation of multiple genes, required cumulatively to achieve a desired phenotype, in a cell or in a multi-cellular organism. The invention is also directed to methods of identifying one or more mutated genes, made by the methods of the invention, in cells and in multi-cellular organisms, by means of a tagging property provided by the insertional mutagen(s). The insertional mutagen thus allows identification of one or more genes that are mutated by insertion of an insertional mutagen. The invention is also directed to methods for correlating a phenotype with a gene by screening or selecting cells that have been mutated by an insertional mutagen incorporated into one or more genes in a cell and identifying the gene or genes causing the phenotype by means of a tagging property in one or more of the insertional mutagens. The invention is also directed to cells and multi-cellular organisms created by the methods of the invention and uses of the cells and multicellular organisms. The invention is also directed to libraries of cells created by the methods of the invention and uses of the libraries.

公开(公告)号：EP1446482A4

公开(公告)日：2006-03-01

申请号：EP02776253

申请日：2002-10-22

申请人： ATHERSYS INC

发明人： HARRINGTON JOHN JOSEPH ,  JACKSON PAUL DAVID ,  JIANG LI

IPC分类号： A01H5/00 ,  A01K67/027 ,  C12N1/19 ,  C12N5/10 ,  C12N15/00 ,  C12N15/01 ,  C12N15/09 ,  C12Q1/04 ,  C12Q1/68 ,  A01K67/00 ,  A01K67/033

CPC分类号： C12N15/102 ,  C12N15/01 ,  C12Q1/6897