-
公开(公告)号：EP3057958B1
公开(公告)日：2019-05-01
申请号：EP14792415.3
申请日：2014-10-16
发明人： AMBERG, Wilhelm , POHLKI, Frauke , LANGE, Udo , WANG, Ying , ZHAO, Hongyu , LI, Huan-Qiu , BREWER, Jason , VASUDEVAN, Anil , LAO, Yanbin , HUTCHINS, Charles W.
IPC分类号： C07D403/12 , C07D233/42 , C07D401/12 , C07D205/04 , C07D207/273 , A61K31/4164 , A61P25/00
-
公开(公告)号：EP3057960B1
公开(公告)日：2019-02-27
申请号：EP14790543.4
申请日：2014-10-16
发明人： AMBERG, Wilhelm , POHLKI, Frauke , LANGE, Udo , WANG, Ying , ZHAO, Hongyu , LI, Huan-Qiu , BREWER, Jason , VASUDEVAN, Anil , LAO, Yanbin , HUTCHINS, Charles W.
IPC分类号： C07D405/14 , C07D311/58 , C07D405/04 , A61K31/352 , A61P25/02
-
3.发明公开4,5-DIHYDROPYRAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 审中-公开4,5-二氢吡唑衍生物，含有它们的药物组合物及其在治疗中的用途
公开(公告)号：EP3191471A1
公开(公告)日：2017-07-19
申请号：EP15762980.9
申请日：2015-09-10
发明人： AMBERG, Wilhelm , BREWER, Jason T. , HUTCHINS, Charles , LANGE, Udo , LAO, Yanbin , LI, Huan-Qiu , POHLKI, Frauke , VASUDEVAN, Anil , WANG, Ying , ZHAO, Hongyu
IPC分类号： C07D403/12
摘要： The present invention relates to 4,5-dihydropyrazole derivatives of the formula (I) and physiologically tolerated salts thereof which are GlyT1 inhibitors. The invention further relates to pharmaceutical compositions comprising such 4,5-dihydropyrazole derivatives, and the use of such 4,5-dihydropyrazole derivatives for therapeutic purposes.
摘要翻译： 本发明涉及式（I）的4,5-二氢吡唑衍生物及其生理学耐受的盐，它们是GlyT1抑制剂。 本发明还涉及包含这种4,5-二氢吡唑衍生物的药物组合物，以及这种4,5-二氢吡唑衍生物用于治疗目的的用途。
-
4.发明授权AMINOCHROMANEs, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 有权AMINOCHROMANDERIVATE，药物组合物，以及它们的食疗
公开(公告)号：EP2739614B1
公开(公告)日：2017-02-22
申请号：EP12743459.5
申请日：2012-08-03
发明人： AMBERG, Wilhelm , LANGE, Udo , POHLKI, Frauke
IPC分类号： C07D311/58 , C07D405/12 , C07D407/12 , C07D409/12 , A61K31/352 , A61P25/02 , A61P25/04 , A61P25/18 , A61P25/28
CPC分类号： C07D405/12 , C07D311/58 , C07D407/12 , C07D409/12
-
5.发明公开N-SUBSTITUTED AMINOBENZOCYCLOHEPTENE, AMINOTETRALINE, AMINOINDANE AND PHENALKYLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 审中-公开N-取代AMINOBENZOCYCLOHEPTEN-，AMINOTETRALIN-，AMINOINDAN- AND苯基烷基胺，含药物组合物及其用途THERAPEUTIC
公开(公告)号：EP2780328A1
公开(公告)日：2014-09-24
申请号：EP12791146.9
申请日：2012-11-19
IPC分类号： C07D233/84 , A61K31/4178 , A61P25/04 , A61P25/18
CPC分类号： C07D403/12 , C07D233/84 , C07D305/08
摘要： The present invention relates to N-substituted aminobenzocycloheptene,aminotetraline, aminoindane and phenalkylamine derivatives of the formula (I),(II), (III) or (IV) or a physiologically tolerated salt thereof. The invention relates topharmaceutical compositions comprising such N-substituted amino-benzocycloheptene,aminotetraline, aminoindane and phenalkylamine derivatives, and the use of such N-substituted aminobenzocycloheptene,aminotetraline, aminoindane and phenalkylamine derivatives for therapeutic purposes. The N-substituted aminobenzocycloheptene,aminotetraline, aminoindane and phenalkylamine derivatives are GlyT1 inhibitors.
-
6.发明公开
公开(公告)号：EP2739614A1
公开(公告)日：2014-06-11
申请号：EP12743459.5
申请日：2012-08-03
发明人： AMBERG, Wilhelm , LANGE, Udo , POHLKI, Frauke
IPC分类号： C07D311/58 , C07D405/12 , C07D407/12 , C07D409/12 , A61K31/352 , A61P25/02 , A61P25/04 , A61P25/18 , A61P25/28
CPC分类号： C07D405/12 , C07D311/58 , C07D407/12 , C07D409/12
摘要： The present invention relates to aminochromane, aminothiochromane and 1,2,3,4-tetrahydroquinoline derivatives of the formula (I), or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, and the use of such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives for therapeutic purposes. The aminochromane, aminothiochromane and amino- 1,2,3,4-tetrahydroquinoline derivatives are GlyT1 inhibitors.
-
公开(公告)号：EP3655392A1
公开(公告)日：2020-05-27
申请号：EP18743735.5
申请日：2018-07-16
发明人： AMBERG, Wilhelm , GENESTE, Hervé , HORNBERGER, Wilfried , LANGE, Udo , MEZLER, Mario , OCHSE, Michael , OELLIEN, Frank , TURNER, Sean C , VAN BERGEIJK, Jeroen , VAN DER KAM, Elizabeth
IPC分类号： C07D217/04 , C07D401/06 , C07D405/06 , C07D409/06 , A61P25/28 , A61K31/4725
-
公开(公告)号：EP3394050A1
公开(公告)日：2018-10-31
申请号：EP16820275.2
申请日：2016-12-22
发明人： AMBERG, Wilhelm , LANGE, Udo , GENESTE, Herve , OCHSE, Michael , BIESINGER, Ralf , OELLIEN, Frank
IPC分类号： C07D405/04 , A61K31/353 , C07C211/00 , C07D205/04 , C07D207/06 , C07D265/38 , C07D211/32 , C07D413/12 , A61P25/00
CPC分类号： C07D413/12 , C07C59/72 , C07C229/30 , C07C229/36 , C07C229/46 , C07C229/48 , C07C229/50 , C07C2601/04 , C07C2601/14 , C07C2602/10 , C07C2602/38 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/16 , C07D209/52 , C07D209/94 , C07D211/32 , C07D211/62 , C07D261/12 , C07D265/36 , C07D265/38 , C07D311/04 , C07D311/58 , C07D405/04 , C07D405/14
摘要： The invention relates to (hetero)cyclic compounds as S1P modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment, alleviation or prevention of diseases or disorders mediated by an S1P receptor.
-
9.发明授权GUANIDINVERBINDUNGEN UND IHRE VERWENDUNG ALS BINDUNGSPARTNER FÜR 5-HT5-REZEPTOREN 有权胍和它们作为结合伴侣5-HT5受体
公开(公告)号：EP1716127B1
公开(公告)日：2014-08-06
申请号：EP05707406.4
申请日：2005-02-15
发明人： NETZ, Astrid , AMBERG, Wilhelm , LANGE, Udo , OCHSE, Michael, c/o Abbott GmbH & Co.KG , HUTCHINS, Charles, W. , GARCIA-LADONA, Francisco-Xavier , WERNET, Wolfgang , KLING, Andreas
IPC分类号： C07D277/48 , C07D417/04 , C07D277/82 , C07D285/12 , C07D285/08 , C07D249/14 , C07D237/22 , C07D231/56 , C07D263/28 , C07D261/14 , A61K31/425
CPC分类号： C07D277/48 , C07D231/56 , C07D235/30 , C07D237/22 , C07D249/14 , C07D261/14 , C07D263/28 , C07D263/48 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D333/36 , C07D417/04 , C07D417/12 , C07D513/04
-
10.发明授权
公开(公告)号：EP3191471B1
公开(公告)日：2020-03-11
申请号：EP15762980.9
申请日：2015-09-10
发明人： AMBERG, Wilhelm , BREWER, Jason T. , HUTCHINS, Charles , LANGE, Udo , LAO, Yanbin , LI, Huan-Qiu , POHLKI, Frauke , VASUDEVAN, Anil , WANG, Ying , ZHAO, Hongyu
IPC分类号： C07D403/12
-
-
-
-
-
-
-
-
-
搜索结果
20 条记录 (耗时 0.035 秒)
