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公开(公告)号：EP3448842A1
公开(公告)日：2019-03-06
申请号：EP17722167.8
申请日：2017-04-24
申请人： AbbVie S.À.R.L. , Galapagos NV
发明人： ALTENBACH, Robert J. , BOGDAN, Andrew , CHAN, Vincent , GRIEME, Timothy A. , KOENIG, John R. , KYM, Philip R. , LIU, Bo , MALAGU, Karine Fabienne , PATEL, Sachin V. , SCANIO, Marc , SEARLE, Xenia B. , SHEKHAR, Shashank , WANG, Xueqing , YEUNG, Ming C.
IPC分类号： C07D311/58 , A61K31/352 , C07D311/60 , C07D407/12 , C07D407/14 , A61P11/00
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公开(公告)号：EP3212189A1
公开(公告)日：2017-09-06
申请号：EP15854320.7
申请日：2015-10-28
申请人： AbbVie S.À.R.L. , Galapagos NV
发明人： KYM, Philip R. , WANG, Xueqing , SEARLE, Xenia B. , LIU, Bo , YEUNG, Ming C. , ALTENBACH, Robert J. , VOIGHT, Eric , BOGDAN, Andrew , KOENIG, John R.
IPC分类号： A61K31/44 , C07D471/04 , C07D311/58
摘要： The invention provides for compounds of formula (I) wherein R1, X, Y, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, m, and R″ have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
摘要翻译： 其中R1，X，Y，R4，R5，R6，R7，R8，R9，R10，R11，R12，R13，R14，m和R“具有本说明书中所定义的任何值及其药学上可接受的盐， 它们可用作治疗由CFTR介导和调节的疾病和病症的药物，包括囊性纤维化，斯耶格伦综合征，胰腺功能不全，慢性阻塞性肺病和慢性阻塞性气道疾病。 还提供了由一种或多种式（I）化合物组成的药物组合物。
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公开(公告)号：EP3523277A1
公开(公告)日：2019-08-14
申请号：EP17794414.7
申请日：2017-10-04
申请人： Abbvie S.a.r.l. , Galapagos NV
发明人： ALTENBACH, Robert J. , BOGDAN, Andrew , DESROY, Nicolas , GFESSER, Gregory A. , GRESZLER, Stephen N. , KOENIG, John R. , KYM, Philip R. , LIU, Bo , SCANIO, Marc J. , SEARLE, Xenia , WANG, Xueqing , YEUNG, Ming C. , ZHAO, Gang
IPC分类号： C07D207/16 , C07D401/12 , A61K31/4025 , A61K31/4439 , A61P11/00
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公开(公告)号：EP3212189B1
公开(公告)日：2020-09-09
申请号：EP15854320.7
申请日：2015-10-28
发明人： KYM, Philip R. , WANG, Xueqing , SEARLE, Xenia B. , LIU, Bo , YEUNG, Ming C. , ALTENBACH, Robert J. , VOIGHT, Eric , BOGDAN, Andrew , KOENIG, John R. , GRESZLER, Stephen N.
IPC分类号： A61K31/44 , C07D471/04 , C07D311/58 , A61K31/397 , A61K31/4025 , A61K31/435 , A61K31/436 , A61K31/4433 , A61K31/453 , A61K31/5377 , A61P11/00
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公开(公告)号：EP3322697B1
公开(公告)日：2019-12-18
申请号：EP16739584.7
申请日：2016-07-14
申请人： Abbvie S.a.r.l. , Galapagos NV
发明人： ALTENBACH, Robert J. , BOGDAN, Andrew , COWART, Marlon D. , ESMIEU, William Ramesh , GFESSER, Gregory A. , GRESZLER, Stephen N. , KOENIG, John R. , KYM, Philip R. , LIU, Bo , MALAGU, Karine Fabienne , PATEL, Sachin V. , SCANIO, Marc J. , SEARLE, Xenia B. , VOIGHT, Eric , WANG, Xueqing , YEUNG, Ming C.
IPC分类号： C07D317/70 , C07D405/12 , C07D407/12 , C07D493/04 , C07D519/00 , A61K31/36 , A61K31/404 , A61K31/426 , A61K31/433 , A61K31/443 , A61K31/4184 , A61K31/501 , A61K31/497 , A61P11/00
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公开(公告)号：EP3322697A1
公开(公告)日：2018-05-23
申请号：EP16739584.7
申请日：2016-07-14
申请人： Abbvie S.a.r.l. , Galapagos NV
发明人： ALTENBACH, Robert J. , BOGDAN, Andrew , COWART, Marlon D. , ESMIEU, William Ramesh , GFESSER, Gregory A. , GRESZLER, Stephen N. , KOENIG, John R. , KYM, Philip R. , LIU, Bo , MALAGU, Karine Fabienne , PATEL, Sachin V. , SCANIO, Marc J. , SEARLE, Xenia B. , VOIGHT, Eric , WANG, Xueqing , YEUNG, Ming C.
IPC分类号： C07D317/70 , C07D405/12 , C07D407/12 , C07D493/04 , C07D519/00 , A61K31/36 , A61K31/404 , A61K31/426 , A61K31/433 , A61K31/443 , A61K31/4184 , A61K31/501 , A61K31/497 , A61P11/00
摘要： wherein X, Y, and R1 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
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