公开(公告)号：EP0866800B1

公开(公告)日：2004-09-22

申请号：EP96943076.8

申请日：1996-12-11

申请人： Abbott GmbH & Co. KG

发明人： AMBERG, Wilhelm ,  BARLOZZARI, Teresa ,  BERNARD, Harald ,  BUSCHMANN, Ernst ,  HAUPT, Andreas ,  HEGE, Hans-Guenther ,  JANSSEN, Bernd ,  KLING, Andreas ,  LIETZ, Helmut ,  RITTER, Kurt ,  ULLRICH, Martina ,  WEYMANN, Jürgen ,  ZIERKE, Thomas

IPC分类号： C07K7/06 ,  A61K38/08 ,  C07K1/00

CPC分类号： A61K38/08

公开(公告)号：EP1123278B1

公开(公告)日：2006-06-21

申请号：EP99953799.6

申请日：1999-10-13

申请人： Abbott GmbH & Co. KG

发明人： BISCHOF, Norbert ,  BUSCHMANN, Ernst ,  HENNINGSEN, Michael ,  KREI, Georg, Arnold ,  MUNSCHAUER, Rainer ,  PFEIFFER, Thomas ,  STEINER, Gerd ,  VIERGUTZ, Wolfgang

IPC分类号： C07D209/52 ,  C07B37/10

CPC分类号： C07D209/52

摘要： The invention relates to a method for producing (+)-exo-6-phenyl-3-azabicyclo-[3.2.0]heptanes of formula (I) in which R represents hydrogen, chlorine, bromine, fluorine or methoxy. The inventive compounds are characterized in that a bisallyl ammonium salt of formula (II), in which R has the above-mentioned meanings and X represents an anion, is photo-cyclized in an inert solvent while adding a sensitizer in a glass apparatus, and the selected (+)-exo-isomer (I) is precipitated as ditoluoyl tartrate using (-)-ditoluoyl tartaric acid from the obtained mixture, and this ditoluoyl tartrate is optionally recrystallized out of an alcohol/water mixture.