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公开(公告)号：EP0866800B1
公开(公告)日：2004-09-22
申请号：EP96943076.8
申请日：1996-12-11
申请人： Abbott GmbH & Co. KG
发明人： AMBERG, Wilhelm , BARLOZZARI, Teresa , BERNARD, Harald , BUSCHMANN, Ernst , HAUPT, Andreas , HEGE, Hans-Guenther , JANSSEN, Bernd , KLING, Andreas , LIETZ, Helmut , RITTER, Kurt , ULLRICH, Martina , WEYMANN, Jürgen , ZIERKE, Thomas
CPC分类号： A61K38/08
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2.发明授权INDENO[1,2-c], NAPHTHO[1,2-c]- AND BENZO[6,7]CYCLOHEPTA[1,2-c]PYRAZOLE DERIVATIVES 有权茚并[1,2-C] - 萘并[1,2-C] - 和苯并[6,7]环庚并[1,2-c]吡唑衍生物
公开(公告)号：EP1023063B1
公开(公告)日：2003-09-10
申请号：EP98951011.0
申请日：1998-10-06
申请人： ABBOTT GmbH & Co. KG
发明人： ARNOLD, Lee, D. , XU, Yajun , BARLOZZARI, Teresa
IPC分类号： A61K31/415 , A61K31/44 , C07D401/04 , C07D409/04 , C07D231/56 , C07D405/04 , C07D231/54
CPC分类号： C07D401/04 , A61K31/416 , A61K31/4439 , C07D231/54 , C07D231/56 , C07D405/04 , C07D409/04
摘要： Chemical compounds that are derivatives of indeno[1,2-c]-, naphtho[1,2-c]- and benzo[6,7]cyclohepta[1,2-c]pyrazole are inhibitors of tyrosine kinase activity. Several of the tyrosine kinases, whose activity is inhibited by these chemical compounds, are involved in hyperproliferative, angiogenic or in vascular hyperpermeability processes. Thus, these chemical compounds can ameliorate disease states where tumor formation, metastasis, angiogenesis, vascular hyperpermeability or endothelial cell proliferation is a factor.
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