公开(公告)号：EP1265909A2

公开(公告)日：2002-12-18

申请号：EP01955779.2

申请日：2001-03-20

申请人： ABBOTT LABORATORIES

发明人： KERDESKY, Francis, A., J. ,  PREMCHANDRAN, Ramiya ,  WAYNE, Gregory, S. ,  CHANG, Sou-Jen ,  PEASE, Jonathan, P. ,  BHAGAVATULA, Lakshmi ,  LALLAMAN, John, E. ,  MORTON, Howard, E. ,  KING, Steven, A.

IPC分类号： C07H17/08 ,  A61K31/7048 ,  A61P31/04

CPC分类号： C07D407/14

摘要： Disclosed herein is a process for the preparation of erythromycin derivatives, or pharmaceutically acceptable salts thereof, which contain an optionally substituted propargyl group at the 6-O-position.

摘要翻译： 本文公开了一种制备在6-O-位上含有任选取代的炔丙基的红霉素衍生物或其药学上可接受的盐的方法。

公开(公告)号：EP1192139A1

公开(公告)日：2002-04-03

申请号：EP00942823.6

申请日：2000-06-15

申请人： Abbott Laboratories

发明人： ALLEN, Michael, S. ,  PREMCHANDRAN, Ramiya, H. ,  CHANG, Sou-Jen ,  CONDON, Stephen ,  DEMATTEI, John, J. ,  KING, Steven, A. ,  KOLACZKOWSKI, Lawrence ,  MANNA, Sukumar ,  NICHOLS, Paul, J. ,  PATEL, Hemant, H. ,  PATEL, Subhash, R. ,  PLATA, Daniel, J. ,  STONER, Eric, J. ,  TIEN, Jien-Heh, J. ,  WITTENBERGER, Steven, J.

IPC分类号： C07D215/14 ,  C07C69/96 ,  C07C68/06 ,  C07C271/12 ,  C07C269/06 ,  C07C43/303 ,  C07C33/03 ,  C07C47/22 ,  C07C57/04

CPC分类号： C07D215/14 ,  C07C68/06 ,  C07C69/96

摘要： The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.

公开(公告)号：EP0885215B1

公开(公告)日：2006-04-19

申请号：EP97905816.1

申请日：1997-02-12

申请人： ABBOTT LABORATORIES

发明人： WINN, Martin ,  BOYD, Steven, A. ,  HUTCHINS, Charles, W. ,  JAE, Hwan-Soo ,  TASKER, Andrew, S. ,  VON GELDERN, Thomas, W. ,  KESTER, Jeffrey, A. ,  SORENSEN, Bryan, K. ,  SZCZEPANKIEWICZ, Bruce, G. ,  HENRY, Kenneth, J., Jr. ,  LIU, Gang ,  WITTENBERGER, Steven, J. ,  KING, Steven, A.

IPC分类号： C07D405/04 ,  C07D207/16 ,  A61K31/40 ,  C07D405/14 ,  C07F9/59 ,  C07F9/572 ,  C07D401/04

CPC分类号： C07D401/04 ,  C07D207/16 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  Y02P20/55

摘要： A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.

公开(公告)号：EP0885215A1

公开(公告)日：1998-12-23

申请号：EP97905816.0

申请日：1997-02-12

申请人： Abbott Laboratories

发明人： WINN, Martin ,  BOYD, Steven, A. ,  HUTCHINS, Charles, W. ,  JAE, Hwan-Soo ,  TASKER, Andrew, S. ,  VON GELDERN, Thomas, W. ,  KESTER, Jeffrey, A. ,  SORENSEN, Bryan, K. ,  SZCZEPANKIEWICZ, Bruce, G. ,  HENRY, Kenneth, J., Jr. ,  LIU, Gang ,  WITTENBERGER, Steven, J. ,  KING, Steven, A.

IPC分类号： A61K31 ,  A61P1 ,  A61P7 ,  A61P9 ,  A61P11 ,  A61P13 ,  A61P25 ,  A61P43 ,  C07D207 ,  C07D211 ,  C07D401 ,  C07D403 ,  C07D405 ,  C07D409 ,  C07D413 ,  C07D417 ,  C07D419 ,  C07D453 ,  C07D471 ,  C07D491 ,  C07F9

CPC分类号： C07D401/04 ,  C07D207/16 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  Y02P20/55

摘要： A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.

公开(公告)号：EP1192139B1

公开(公告)日：2012-04-18

申请号：EP00942823.6

申请日：2000-06-15

申请人： ABBOTT LABORATORIES

发明人： ALLEN, Michael, S. ,  PREMCHANDRAN, Ramiya, H. ,  CHANG, Sou-Jen ,  CONDON, Stephen ,  DEMATTEI, John, J. ,  KING, Steven, A. ,  KOLACZKOWSKI, Lawrence ,  MANNA, Sukumar ,  NICHOLS, Paul J. ,  PATEL, Hemant, H. ,  PATEL, Subhash, R. ,  PLATA, Daniel, J. ,  STONER, Eric, J. ,  TIEN, Jien-Heh, J. ,  WITTENBERGER, Steven, J.

IPC分类号： C07D215/14 ,  C07C69/96 ,  C07C68/06 ,  C07C271/12 ,  C07C269/06 ,  C07C43/303 ,  C07C33/03 ,  C07C47/22 ,  C07C57/04

CPC分类号： C07D215/14 ,  C07C68/06 ,  C07C69/96

摘要： The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.

公开(公告)号：EP1114022A1

公开(公告)日：2001-07-11

申请号：EP99946886.1

申请日：1999-09-13

申请人： ABBOTT LABORATORIES

发明人： JI, Jianguo ,  BARNES, David, M. ,  KING, Steven, A. ,  PLAGGE, Frederick, A. ,  WITTENBERGER, Steven, J. ,  ZHANG, Ji

IPC分类号： C07C201/12 ,  C07D317/64 ,  C07D405/04 ,  C07D263/52 ,  C07C251/18

CPC分类号： C07D317/64 ,  C07D405/04

摘要： The present invention relates to producing stereoselective nitro compounds by reacting a dicarbonyl compound with a nitrostyrene compound in the presence of a catalyst complex and a base.

公开(公告)号：EP1003740A2

公开(公告)日：2000-05-31

申请号：EP98937139.8

申请日：1998-07-27

申请人： Abbott Laboratories

发明人： WINN, Martin ,  BOYD, Steven, A. ,  HUTCHINS, Charles, W. ,  JAE, Hwan-Soo ,  TASKER, Andrew, S. ,  von GELDERN, Thomas, W. ,  KESTER, Jeffrey, A. ,  SORENSEN, Bryan, K. ,  SZCZEPANKIEWICZ, Bruce, G. ,  HENRY, Kenneth, J. ,  LIU, Gang ,  WITTENBERGER, Steven, J. ,  KING, Steven, A.

IPC分类号： C07D405/00

CPC分类号： C07D207/27 ,  C07D207/16 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

摘要： A compound of formula (I), or a pharmaceutically acceptable salt thereof, is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.