公开(公告)号：EP2435080A2

公开(公告)日：2012-04-04

申请号：EP10720520.5

申请日：2010-05-26

申请人： Abbott Laboratories

发明人： JI, Jianguo ,  LEE, Chih-Lung ,  SIPPY, Kevin, B. ,  LI, Tao ,  GOPALAKRISHNAN, Murali

IPC分类号： A61K45/06 ,  A61P29/00 ,  A61P25/04 ,  A61K31/4245 ,  A61K31/4427

CPC分类号： A61K45/06 ,  A61K31/4245 ,  A61K31/4427 ,  A61K2300/00

摘要： This invention discloses a method of treatment of osteoarthritis pain by administration of a composition containing a nicotinic acetylcholine receptor ligand and a nicotinic acetylcholine receptor subtype 4 2 allosteric modulator. The present application also relates to compositions comprising such compounds for use in treating pain and related disorders mediated by controlling neurotransmitter release in a subject.

公开(公告)号：EP2018380B1

公开(公告)日：2011-10-19

申请号：EP07797473.1

申请日：2007-05-15

申请人： ABBOTT LABORATORIES

发明人： JI, Jianguo ,  LI, Tao ,  LYNCH, Christopher L. ,  GOPALAKRISHNAN, Murali

IPC分类号： C07D451/08 ,  C07D451/14 ,  C07D519/00 ,  A61K31/4375 ,  A61P25/00

CPC分类号： C07D451/08 ,  C07D451/14 ,  C07D519/00

摘要： The invention relates to fused bicycloheterocycle substituted azabicyclic alkane derivatives of formula (I), or a pharmaceutically acceptable salt, ester, amid, or prodrug thereof, wherein n is 1, 2 or 3; A is N or N+-O-; R is hydrogen, alkyl, cycloalkylalkyl and arylalkyl; L is selected from the group consisting of O, S, and -N(Ra)-; Ar1 is a 6-membered aryl or 6 membered heteroaryl ring; and Ar2 is a bicyclic heteroaryl; and Ra is selected from the group consisting of hydrogen, alkyl and alkylcarbonyl; provided that if Ar1 is Formula (II), then L is O or S. Compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：EP2231657A1

公开(公告)日：2010-09-29

申请号：EP08852111.7

申请日：2008-11-20

申请人： Abbott Laboratories

发明人： JI, Jianguo ,  LI, Tao ,  SIPPY, Kevin B ,  LEE, Chih-Hung ,  GOPALAKRISHNAN, Murali

IPC分类号： C07D451/04 ,  C07D451/06 ,  A61K31/46 ,  A61P25/00

CPC分类号： C07D451/04 ,  A61K31/46 ,  C07D451/06

摘要： The invention relates to biaryl substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：EP2146985A1

公开(公告)日：2010-01-27

申请号：EP07865508.1

申请日：2007-12-12

申请人： ABBOTT LABORATORIES

发明人： LEE, Chih-hung ,  JI, Jianguo ,  LI, Tao ,  SCHRIMPF, Michael, R. ,  SIPPY, Kevin, B. ,  GOPALAKRISHNAN, Murali

IPC分类号： C07D413/14 ,  A61K31/4245 ,  A61P25/28

CPC分类号： C07D413/14

摘要： The invention relates to heterocyclic derivatives, compositions comprising such compounds, and methods of preventing or treating conditions and disorders using such compounds and compositions. The heterocyclic derivatives, more particularly can be substituted oxadiazole compounds and derivatives thereof.

公开(公告)号：EP1824848A1

公开(公告)日：2007-08-29

申请号：EP04813737.6

申请日：2004-12-10

申请人： ABBOTT LABORATORIES

发明人： JI, Jianguo ,  LI, Tao ,  MORTELL, Kathleen H. ,  SCHRIMPF, Michael R. ,  NERSESIAN, Diana L. ,  PAN, Liping

IPC分类号： C07D453/02 ,  A61K31/439 ,  A61P25/28

CPC分类号： C07D453/02

摘要： Compounds of formula (I) wherein n is 0, 1, or 2; A is N or N+-O-; X is O, S, -NH-, and -N-alkyl-; Ar1 is a 6-membered aromatic ring; and Ar2 is a fused bicycloheterocycle. The compounds are useful in treating conditions or disorders prevented by or ameliorated by a7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.

公开(公告)号：EP1664045A1

公开(公告)日：2006-06-07

申请号：EP04784568.0

申请日：2004-09-17

申请人： ABBOTT LABORATORIES

发明人： BASHA, Anwer ,  BUNNELLE, William, H. ,  DART, Michael, J. ,  GALLAGHER, Megan, E. ,  JI, Jianguo ,  PACE, Jennifer, M. ,  RYTHER, Keith, B. ,  TIETJE, Karin, R. ,  MORTELL, Kathleen, H. ,  NERSESIAN, Diana, L. ,  SCHRIMPF, Michael, R. ,  LI, Tao

IPC分类号： C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D471/08 ,  A61K31/435 ,  A61P25/00

CPC分类号： C07D487/08 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04

摘要： Compounds of formula (I) Z-Ar 1 -Ar 2 wherein Z is a diazabicyclic amine, Ar 1 is a 5- or 6-membered aromatic ring, and Ar 2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.

公开(公告)号：EP2231672A1

公开(公告)日：2010-09-29

申请号：EP08853111.6

申请日：2008-11-20

申请人： Abbott Laboratories

发明人： JI, Jianguo ,  LI, Tao ,  SIPPY, Kevin B ,  LEE, Chih-hung ,  GOPALAKRISHNAN, Murali

IPC分类号： C07D487/04 ,  A61K31/407 ,  A61P25/00

CPC分类号： C07D487/04

摘要： The invention relates biaryl substituted diazabicycloalkanes of foraula (I), and more particularly bicycloheteroaryl substituted fused diazabicycloalkane derivatives, compositions comprising such compounds, and such compounds for use for treating or preventing conditions and disorders related to both

摘要翻译： 本发明涉及方（（I）的联芳基取代的二氮杂双环烷烃，更具体地涉及双环杂芳基取代的稠合二氮杂双环烷烃衍生物，包含此类化合物的组合物，以及用于治疗或预防与

公开(公告)号：EP2099795A2

公开(公告)日：2009-09-16

申请号：EP07863920.0

申请日：2007-11-06

申请人： ABBOTT LABORATORIES

发明人： SCHRIMPF, Michael R ,  NERSESIAN, Diana L ,  SIPPY, Kevin B ,  JI, Jianguo ,  LI, Tao ,  SCANIO, Marc ,  SHI, Lei ,  LEE, Chih-hung ,  BUNNELLE, Willaim H ,  ZHANG, Geoff G.Z. ,  BRACKEMEYER, Paul J ,  CHEN, Shuang ,  HENRY, Rodger F

IPC分类号： C07D451/14 ,  A61K31/395

CPC分类号： C07D471/18 ,  A61K31/095 ,  A61K31/439 ,  A61K31/444 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K45/06 ,  C07C309/29 ,  C07D451/14 ,  C07D471/08 ,  C07F5/022

摘要： The invention relates to compounds that are azaadamantane derivatives of formula (I), particularly ether- or amine -substituted azaadamantane derivatives and salts and prodrugs thereof, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.

公开(公告)号：EP1699785A2

公开(公告)日：2006-09-13

申请号：EP04813664.2

申请日：2004-12-10

申请人： ABBOTT LABORATORIES

发明人： JI, Jianguo ,  LI, Tao ,  WANG, Ying

IPC分类号： C07D453/00 ,  A61K31/439 ,  A61P25/00

CPC分类号： C07D453/02

摘要： Compounds of formula (I); wherein A is N or N+-O-; n is 0, 1, or 2; Y is O, S, -NH-, and -N-alkyl-; Ar1 is both 6-membered aromatic rings; Ar2 is 5- or 6-membered aromatic rings with a -NR8R9 group, as defined herein. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.

摘要翻译： 式（I）化合物; 其中A是N或N + -O-; n是0,1或2; Y是O，S，-NH-和-N-烷基 - ; Ar1都是6元芳环; Ar 2是如本文所定义的具有-NR 8 R 9基团的5元或6元芳族环。 该化合物可用于治疗由α7nAChR配体阻止或改善的病症或障碍。 还公开了具有式（I）化合物的药物组合物和使用这些化合物和组合物的方法。

公开(公告)号：EP1284976A2

公开(公告)日：2003-02-26

申请号：EP01944118.7

申请日：2001-04-27

申请人： Abbott Laboratories

发明人： SCHRIMPF, Michael, R. ,  TIETJE, Karin, R. ,  TOUPENCE, Richard, B. ,  JI, Jianguo ,  BASHA, Anwer ,  BUNNELLE, William, H. ,  DAANEN, Jerome, F. ,  PACE, Jennifer, M. ,  SIPPY, Kevin, B.

IPC分类号： C07D487/00

CPC分类号： C07D471/04 ,  C07D487/04

摘要： Compounds of formula (I), pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals (nicotinic acetylcholine receptor ligands).