公开(公告)号：EP1751149B1

公开(公告)日：2012-06-06

申请号：EP05743943.2

申请日：2005-04-29

申请人： Abbott Laboratories

发明人： ALTENBACH, Robert, J. ,  BLACK, Lawrence, A. ,  CHANG, Sou-jen ,  COWART, Marlon, D. ,  FAGHIH, Ramin ,  GFESSER, Gregory, A. ,  KU, Yi-yin ,  LIU, Huaqing ,  LUKIN, Kirill, A. ,  NERSESIAN, Diana, L. ,  PU, Yu-ming ,  CURTIS, Michael, P.

IPC分类号： C07D401/08 ,  C07D417/14 ,  C07D401/04 ,  C07D417/04 ,  C07D413/04 ,  C07D409/14 ,  C07D215/12 ,  C07D401/14 ,  A61K31/4709 ,  A61P25/28 ,  A61P25/00 ,  C07D413/14

CPC分类号： C07D215/12 ,  C07D401/04 ,  C07D401/08 ,  C07D401/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

摘要： Compounds of formula (I) wherein R1 or R2 is an aromatic or non-aromatic ring directly joined or joined by a linker, as represented by L2 and L3, to a heteroaromatic core, and X, X', Y, Y', Z, Z', R1, R2, R3, R3a, R3b, R4, R5, L, L2, and L3 are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

公开(公告)号：EP1345954A2

公开(公告)日：2003-09-24

申请号：EP01992462.0

申请日：2001-12-19

申请人： Abbott Laboratories

发明人： LUKIN, Kirill, A.

IPC分类号： C07H17/08 ,  A61K31/7048 ,  A61P31/04

CPC分类号： C07H17/08

摘要： An efficient deoximation technique for use in synthesis of erythromycin derivatives, involving aryl thioimine intermediates is disclosed. The aryl thioimine intermediates can be utilized in a method for protecting a ketone of a ketone-containing erythromycin derivative as a thioimine; a method for deoximating an oxime-containing erythromycin derivative, or a method for preparing a 6-O-alkyl erythromycin derivative. Presently preferred erythromycin derivatives have a C-9 oxime or a C-9 ketone.

公开(公告)号：EP1751130A2

公开(公告)日：2007-02-14

申请号：EP05763655.7

申请日：2005-04-29

申请人： ABBOTT LABORATORIES

发明人： ALTENBACH, Robert, J. ,  BLACK, Lawrence, A. ,  CHANG, Sou-jen ,  COWART, Marlon, D. ,  FAGHIH, Ramin ,  GFESSER, Gregory, A. ,  KU, Yi-yin ,  LIU, Huaqing ,  LUKIN, Kirill, A. ,  NERSESIAN, Diana, L. ,  PU, Yu-ming ,  CURTIS, Michael, P.

IPC分类号： C07D401/00

CPC分类号： C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

摘要： Compounds of formula (I) wherein R1 or R2 is a tricyclic or bicyclic ring, each of which contains at least two heteroatoms, and R1, R2, R3, R3a, R3b, R4, R5, L, X, X', Y, Y', Z, and Z' are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

公开(公告)号：EP1345954B1

公开(公告)日：2008-06-04

申请号：EP01992462.0

申请日：2001-12-19

申请人： ABBOTT LABORATORIES

发明人： LUKIN, Kirill, A.

IPC分类号： C07H17/08 ,  A61K31/7048 ,  A61P31/04

CPC分类号： C07H17/08

摘要： An efficient deoximation technique for use in synthesis of erythromycin derivatives, involving aryl thioimine intermediates is disclosed. The aryl thioimine intermediates can be utilized in a method for protecting a ketone of a ketone-containing erythromycin derivative as a thioimine; a method for deoximating an oxime-containing erythromycin derivative, or a method for preparing a 6-O-alkyl erythromycin derivative. Presently preferred erythromycin derivatives have a C-9 oxime or a C-9 ketone.

公开(公告)号：EP1751149A1

公开(公告)日：2007-02-14

申请号：EP05743943.2

申请日：2005-04-29

申请人： ABBOTT LABORATORIES

发明人： ALTENBACH, Robert, J. ,  BLACK, Lawrence, A. ,  CHANG, Sou-jen ,  COWART, Marlon, D. ,  FAGHIH, Ramin ,  GFESSER, Gregory, A. ,  KU, Yi-yin ,  LIU, Huaqing ,  LUKIN, Kirill, A. ,  NERSESIAN, Diana, L. ,  PU, Yu-ming ,  CURTIS, Michael, P.

IPC分类号： C07D417/14 ,  C07D401/04 ,  C07D417/04 ,  C07D413/04 ,  C07D409/14 ,  C07D413/14 ,  C07D215/12 ,  C07D401/14 ,  A61K31/4709 ,  A61P25/28 ,  A61P25/00

CPC分类号： C07D215/12 ,  C07D401/04 ,  C07D401/08 ,  C07D401/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

摘要： Compounds of formula (I) wherein R1 or R2 is an aromatic or non-aromatic ring directly joined or joined by a linker, as represented by L2 and L3, to a heteroaromatic core, and X, X', Y, Y', Z, Z', R1, R2, R3, R3a, R3b, R4, R5, L, L2, and L3 are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

公开(公告)号：EP2323989A2

公开(公告)日：2011-05-25

申请号：EP09722850.6

申请日：2009-03-20

申请人： Abbott Laboratories

发明人： LUKIN, Kirill, A. ,  KOTECKI, Brian, J. ,  YU, Su ,  WANG, Lei ,  HAIGHT, Anthony, R.

IPC分类号： C07D231/56

CPC分类号： C07D231/56

摘要： The invention discloses compounds of formula ( II ): and methods of making the compounds, which are VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.

摘要翻译： 本发明公开了式（II）的化合物：以及制备这些化合物的方法，所述化合物是可用于治疗疼痛，炎性热痛觉过敏，尿失禁和膀胱过度活动的VR1拮抗剂。

公开(公告)号：EP1569637A1

公开(公告)日：2005-09-07

申请号：EP03768721.7

申请日：2003-11-05

申请人： ABBOTT LABORATORIES

发明人： ALTENBACH, Robert, J. ,  BLACK, Lawrence, A. ,  CHANG, Sou-Jen ,  COWART, Marlon, D. ,  FAGHIH, Ramin ,  GFESSER, Gregory, A.; ,  KU, Yi-Yin ,  LIU, Huaqing ,  LUKIN, Kirill, A. ,  NERSESIAN, Diana, L. ,  PU, Yu-ming ,  SHARMA, Padam, N. ,  BENNANI, Youssef, L. ,  CURTIS, Michael, P.

IPC分类号： A61K31/40 ,  C07D295/155 ,  C07D295/116 ,  A61P25/00 ,  A61P3/00 ,  C07D261/08 ,  C07D207/08 ,  C07D207/12 ,  C07D207/14 ,  C07C255/58 ,  C07D295/088 ,  C07D207/20 ,  C07D215/12 ,  C07D215/14 ,  C07D217/14

CPC分类号： C07C255/58 ,  C07D207/08 ,  C07D207/12 ,  C07D207/14 ,  C07D207/20 ,  C07D213/30 ,  C07D213/38 ,  C07D213/61 ,  C07D213/64 ,  C07D213/85 ,  C07D215/12 ,  C07D215/14 ,  C07D215/20 ,  C07D217/14 ,  C07D237/12 ,  C07D237/14 ,  C07D237/28 ,  C07D239/26 ,  C07D239/28 ,  C07D239/42 ,  C07D239/52 ,  C07D241/12 ,  C07D241/42 ,  C07D263/32 ,  C07D277/28 ,  C07D295/073 ,  C07D295/088 ,  C07D295/096 ,  C07D295/112 ,  C07D295/135 ,  C07D295/155 ,  C07D401/04 ,  C07D401/10 ,  C07D403/04 ,  C07D403/10 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04

摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).