公开(公告)号：EP3523293A1

公开(公告)日：2019-08-14

申请号：EP17794779.3

申请日：2017-10-06

申请人： Abbvie S.a.r.l. ,  Galapagos N.V.

发明人： ALTENBACH, Robert J. ,  BOGDAN, Andrew ,  COUTY, Sylvain ,  DE LEMOS, Elsa ,  DESROY, Nicolas ,  DUTHION, Béranger ,  GFESSER, Gregory A. ,  GRESZLER, Stephen N. ,  HOUSSEMAN, Christopher Gaëtan ,  KOENIG, John R. ,  KYM, Philip R. ,  LIU, Bo ,  SCANIO, Marc J. ,  SEARLE, Xenia ,  WANG, Xueqing ,  YEUNG, Ming C. ,  ZHAO, Gang

IPC分类号： C07D401/14 ,  C07D401/04 ,  C07D405/06 ,  C07D207/14 ,  C07D207/48 ,  A61P11/00 ,  A61K31/4025

公开(公告)号：EP3322697A1

公开(公告)日：2018-05-23

申请号：EP16739584.7

申请日：2016-07-14

申请人： Abbvie S.a.r.l. ,  Galapagos NV

发明人： ALTENBACH, Robert J. ,  BOGDAN, Andrew ,  COWART, Marlon D. ,  ESMIEU, William Ramesh ,  GFESSER, Gregory A. ,  GRESZLER, Stephen N. ,  KOENIG, John R. ,  KYM, Philip R. ,  LIU, Bo ,  MALAGU, Karine Fabienne ,  PATEL, Sachin V. ,  SCANIO, Marc J. ,  SEARLE, Xenia B. ,  VOIGHT, Eric ,  WANG, Xueqing ,  YEUNG, Ming C.

IPC分类号： C07D317/70 ,  C07D405/12 ,  C07D407/12 ,  C07D493/04 ,  C07D519/00 ,  A61K31/36 ,  A61K31/404 ,  A61K31/426 ,  A61K31/433 ,  A61K31/443 ,  A61K31/4184 ,  A61K31/501 ,  A61K31/497 ,  A61P11/00

摘要： wherein X, Y, and R1 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

公开(公告)号：EP3212184A1

公开(公告)日：2017-09-06

申请号：EP15854248.0

申请日：2015-10-29

申请人： Abbvie S.a.r.l. ,  Galapagos NV

发明人： KYM, Philip R. ,  WANG, Xueqing ,  SEARLE, Xenia B. ,  LIU, Bo ,  YEUNG, Ming C.

IPC分类号： A61K31/36 ,  A61K31/351 ,  A61P11/00

摘要： Compounds of formula (I) and pharmaceutically acceptable salts or radiolabelled forms thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and m are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

摘要翻译： 其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11，R 12和m如说明书中所定义的式（I）化合物及其药学可接受的盐或放射标记的形式是有用的 用于治疗由囊性纤维化跨膜电导调节剂（CFTR）蛋白阻止或改善的病症或障碍。 描述了制备这些化合物的方法。 还描述了式（I）化合物的药物组合物，以及使用这些化合物和组合物的方法。

公开(公告)号：EP3523277A1

公开(公告)日：2019-08-14

申请号：EP17794414.7

申请日：2017-10-04

申请人： Abbvie S.a.r.l. ,  Galapagos NV

发明人： ALTENBACH, Robert J. ,  BOGDAN, Andrew ,  DESROY, Nicolas ,  GFESSER, Gregory A. ,  GRESZLER, Stephen N. ,  KOENIG, John R. ,  KYM, Philip R. ,  LIU, Bo ,  SCANIO, Marc J. ,  SEARLE, Xenia ,  WANG, Xueqing ,  YEUNG, Ming C. ,  ZHAO, Gang

IPC分类号： C07D207/16 ,  C07D401/12 ,  A61K31/4025 ,  A61K31/4439 ,  A61P11/00

公开(公告)号：EP3585784A1

公开(公告)日：2020-01-01

申请号：EP18710151.4

申请日：2018-02-23

申请人： Abbvie S.a.r.l. ,  Galapagos NV

发明人： ALTENBACH, Robert J. ,  BOGDAN, Andrew ,  DESROY, Nicolas ,  GFESSER, Gregory A. ,  GRESZLER, Stephen N. ,  KYM, Philip R. ,  LIU, Bo ,  MALAGU, Karine Fabienne ,  MERAYO MERAYO, Nuria ,  PIZZONERO, Mathieu Rafaël ,  SEARLE, Xenia B. ,  VAN DER PLAS, Steven Emiel ,  WANG, Xueqing ,  YEUNG, Ming C. ,  ZHAO, Gang

IPC分类号： C07D405/12 ,  C07D407/12 ,  C07D319/22 ,  C07D307/16 ,  A61P3/04 ,  A61K31/381 ,  A61K31/343

公开(公告)号：EP3322697B1

公开(公告)日：2019-12-18

申请号：EP16739584.7

申请日：2016-07-14

申请人： Abbvie S.a.r.l. ,  Galapagos NV

发明人： ALTENBACH, Robert J. ,  BOGDAN, Andrew ,  COWART, Marlon D. ,  ESMIEU, William Ramesh ,  GFESSER, Gregory A. ,  GRESZLER, Stephen N. ,  KOENIG, John R. ,  KYM, Philip R. ,  LIU, Bo ,  MALAGU, Karine Fabienne ,  PATEL, Sachin V. ,  SCANIO, Marc J. ,  SEARLE, Xenia B. ,  VOIGHT, Eric ,  WANG, Xueqing ,  YEUNG, Ming C.

IPC分类号： C07D317/70 ,  C07D405/12 ,  C07D407/12 ,  C07D493/04 ,  C07D519/00 ,  A61K31/36 ,  A61K31/404 ,  A61K31/426 ,  A61K31/433 ,  A61K31/443 ,  A61K31/4184 ,  A61K31/501 ,  A61K31/497 ,  A61P11/00

公开(公告)号：EP3736270A1

公开(公告)日：2020-11-11

申请号：EP20183402.5

申请日：2018-09-13

申请人： AbbVie Overseas S.à r.l. ,  Galapagos N.V.

发明人： ALTENBACH, Robert J ,  BOGDAN, Andrew ,  COUTY, Sylvain ,  DESROY, Nicolas ,  GFESSER, Gregory A. ,  HOUSSEMAN, Christopher Gaëtan ,  KYM, Philip R. ,  LIU, Bo ,  MAI, Thi Thu Trang ,  MALAGU, Karine Fabienne ,  MERAYO MERAYO, Nuria ,  PICOLET, Olivier Laurent ,  PIZZONERO, Mathieu Rafaël ,  SEARLE, Xenia B. ,  VAN DER PLAS, Steven Emiel ,  WANG, Xueqing ,  YEUNG, Ming C.

IPC分类号： C07D401/12 ,  C07D213/71 ,  C07D215/36 ,  C07D231/56 ,  C07D235/28 ,  C07D471/04 ,  C07D213/64 ,  C07C311/45 ,  A61P11/00 ,  A61K31/4709

摘要： Compounds of Formula (I) are disclosed:

wherein A 1 , R 1 , R 2 , R 3 , R 4 , and n are as defined herein. Also disclosed is the use of the compounds in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering the compounds.

公开(公告)号：EP3865474A1

公开(公告)日：2021-08-18

申请号：EP21164249.1

申请日：2018-09-13

申请人： AbbVie Overseas S.à r.l. ,  Galapagos N.V.

发明人： ALTENBACH, Robert J ,  BOGDAN, Andrew ,  COUTY, Sylvain ,  DESROY, Nicolas ,  GFESSER, Gregory A. ,  HOUSSEMAN, Christopher Gaëtan ,  KYM, Philip R. ,  LIU, Bo ,  MALAGU, Karine Fabienne ,  MERAYO MERAYO, Nuria ,  PICOLET, Olivier Laurent ,  PIZZONERO, Mathieu Rafaël ,  SEARLE, Xenia B. ,  VAN DER PLAS, Steven Emiel ,  WANG, Xueqing ,  YEUNG, Ming C. ,  MAI, Thi Thu Trang

IPC分类号： C07D213/71 ,  C07D215/36 ,  C07D231/56 ,  C07D401/12 ,  C07D235/28 ,  C07D471/04 ,  C07D213/64 ,  C07C311/45 ,  A61P11/00 ,  A61K31/4709

摘要： The invention discloses compounds of Formula (I):

wherein A 1 , R 1 , R 2 , R 3 , R 4 , and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis and pharmaceutical compositions comprising the same. Also disclosed are methods for their production and methods of treating cystic fibrosis by administering the compounds.

公开(公告)号：EP3736267A1

公开(公告)日：2020-11-11

申请号：EP20183405.8

申请日：2018-09-13

申请人： AbbVie Overseas S.à r.l. ,  Galapagos N.V.

发明人： ALTENBACH, Robert J ,  BOGDAN, Andrew ,  COUTY, Sylvain ,  DESROY, Nicolas ,  GFESSER, Gregory A. ,  HOUSSEMAN, Christopher Gaëtan ,  KYM, Philip R. ,  LIU, Bo ,  MAI, Thi Thu Trang ,  MALAGU, Karine Fabienne ,  MERAYO MERAYO, Nuria ,  PICOLET, Olivier Laurent ,  PIZZONERO, Mathieu Rafaël ,  SEARLE, Xenia B. ,  VAN DER PLAS, Steven Emiel ,  WANG, Xueqing ,  YEUNG, Ming C.

IPC分类号： C07D215/36 ,  C07D213/64 ,  C07D213/71 ,  C07D231/56 ,  C07D235/28 ,  C07D401/12 ,  C07D471/04 ,  C07C311/45 ,  A61P11/00 ,  A61K31/4709

摘要： Compounds of Formula (I) are disclosed:

wherein A 1 , R 1 , R 2 , R 3 , R 4 , and n are as defined herein. Also disclosed is the use of the compounds in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering the compounds.