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13 条记录 (耗时 0.013 秒)

    CYCLIC CARBOXAMIDE COMPOUNDS AND ANALOGUES THEREOF AS OF HEPATITIS C VIRUS
    5.
    发明公开
    CYCLIC CARBOXAMIDE COMPOUNDS AND ANALOGUES THEREOF AS OF HEPATITIS C VIRUS 审中-公开
    环状羧酸酰胺化合物及其类似物作为对丙型肝炎病毒剂

    公开(公告)号：EP2350114A1

    公开(公告)日：2011-08-03

    申请号：EP09756637.6

    申请日：2009-11-20

    申请人： Achillion Pharmaceuticals, Inc.

    发明人： ZHANG, Suoming ,  PHADKE, Avinash ,  DESHPANDE, Milind ,  GADHACHANDA, Venkat

    IPC分类号： C07K5/02 ,  A61K38/00

    CPC分类号： C07K5/0808 ,  C07K5/0819

    摘要： The invention provides cyclic carboxamide compounds and analogues thereof of Formula (I) and the pharmaceutically salts and hydrates thereof. The variables R, R
    1 , R
    6 -R
    8 , R
    16 , R
    18 , R
    19 , M, n, T, Y, and Z are defined herein. Certain compounds of Formula (I) are useful as antiviral agents. Certain cyclic carboxamide compounds and cyclic carboxamide analogues disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more cyclic carboxamide compounds or cyclic carboxamide analogues and one or more pharmaceutically acceptable carriers. Such pharmaceutical compositions may contain a cyclic carboxamide compound or cyclic carboxamide analogue as the only active agent or may contain a combination of a cyclic carboxamide compound or cyclic carboxamide analogue and one or more other pharmaceutically active agents. The invention also provides methods for treating viral infections, including Hepatitis C infections.

    THIAZOLE COMPOUNDS AND METHODS OF USE
    8.
    发明公开
    THIAZOLE COMPOUNDS AND METHODS OF USE 审中-公开
    噻唑和其使用方法

    公开(公告)号：EP1879575A2

    公开(公告)日：2008-01-23

    申请号：EP06770077.3

    申请日：2006-05-09

    申请人： Achillion Pharmaceuticals, Inc.

    发明人： ZHANG, Suoming ,  PHADKE, Avinash ,  LIU, Cuixian ,  WANG, Xiangzhu ,  QUINN, Jesse ,  CHEN, Dawei ,  GADHACHANDA, Venkat ,  LI, Shouming ,  DESHPANDE, Milind

    IPC分类号： A61K31/426 ,  A61K31/427 ,  A61P31/12 ,  C07D487/04

    CPC分类号： C07D487/04 ,  C07D277/38 ,  C07D277/42 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04

    摘要： The present invention provides compounds, salts and hydrates of Formula I, wherein the variables Ar1R2, R3, R4, r, q, and t are defined herein. Certain compounds of Formula I described herein possess potent antiviral activity. The invention also provides compounds of Formula I that are potent and/ or selective inhibitors of Hepatitis C virus replication. Certain compounds described herein inhibit assembly of the HCV replication complex. The invention also provides pharmaceutical compositions containing one or more compounds of Formula I, or a salt, solvate, or acylated prodrug of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents. The invention further comprises methods of treating patients suffering from certain infectious diseases by administering to such patients an amount of a compound of Formula I effective to reduce signs or symptoms of the disease. These infectious diseases include viral infections, particularly HCV infections. The invention is particularly includes methods of treating human patients suffering from an infectious disease, but also encompasses methods of treating other animals, including livestock and domesticated companion animals, suffering from an infectious disease. Methods of treatment include administering a compound of Formula I as a single active agent or administering a compound of Formula I in combination with on or more other therapeutic agent.

    NOVEL PROCESSES FOR PRODUCING SOVAPREVIR
    10.
    发明公开
    NOVEL PROCESSES FOR PRODUCING SOVAPREVIR 有权
    VERFAHREN ZUR HERSTELLUNG VON SOVAPREVIR

    公开(公告)号：EP2970195A2

    公开(公告)日：2016-01-20

    申请号：EP14722457.0

    申请日：2014-03-14

    申请人： Achillion Pharmaceuticals, Inc.

    发明人： PHADKE, Avinash ,  HASHIMOTO, Akihiro ,  GADHACHANDA, Venkat

    IPC分类号： C07D401/12

    CPC分类号： C07K5/06139 ,  C07B2200/13 ,  C07D207/16 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07K5/0821

    摘要： The disclosure includes novel processes for producing Sovaprevir comprising adding compound E to F-1 to provide Sovaprevir. The disclosure further includes intermediates useful for producing Sovaprevir. The disclosure also includes a novel crystalline form of Sovaprevir, Form F, and a method for preparing spray-dried amorphous Sovaprevir from crystalline Form F.

    摘要翻译： 本公开包括用于生产索普雷维的新方法，其包括向F-1中加入化合物E以提供索伐他韦。 本公开还包括可用于生产索普伐维尔的中间体。 本公开还包括新型结晶形式的Sovaprevir，Form F，以及从晶型F制备喷雾干燥的无定形Sovaprevir的方法。