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公开(公告)号：EP0969863A1
公开(公告)日：2000-01-12
申请号：EP97941679.9
申请日：1997-09-18
发明人： SHIH, Chiaho , YUAN, Ta-Tung
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/292 , C12N7/00 , C12N2730/10122 , C12N2730/10132 , C12N2730/10134 , Y10S977/802 , Y10S977/805 , Y10S977/915 , Y10S977/918
摘要： The present invention provides a composition of matter comprising a defective interfering virus particle, wherein said particle naturally occurs in a human infection and wherein said particle has a naturally occurring core antigen internal deletion. Provided is a pharmaceutical composition, comprising defective interfering virus particle and a pharmaceutically acceptable carrier. Provided is a method for preparing defective intefering virus, comprising the steps of: (1) introducing a defective interfering virus and a complementing plasmid expressing a wild type virus core antigen and optionally containing a drug resistance gene, into a recipient cell; (2) selecting for stably tranfected colonies; (3) growing the drug resistant cells and screening for the production of virus DNA replication; and (4) collecting defective interfering virus particles from the medium. Further provided is a vaccine, comprising a defective interfering virus particle.
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2.发明公开HIGH-EFFICIENCY FUSOGENIC VESICLES, METHODS OF PRODUCING THEM, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开融合为他们的药物高融合效率，生产方法和组合物含统一气泡
公开(公告)号：EP1562550A1
公开(公告)日：2005-08-17
申请号：EP03779993.9
申请日：2003-11-19
申请人： Pevion Biotech Ltd.
IPC分类号： A61K9/127
CPC分类号： A61K9/1272 , A61K9/1271 , Y10S977/799 , Y10S977/80 , Y10S977/801 , Y10S977/802 , Y10S977/803 , Y10S977/804 , Y10S977/805 , Y10S977/808
摘要： The present invention relates to novel fusogenic vesicles as highly efficient and versatile encapsulation systems for delivering a substance of choice, such as nucleic acids, proteins, peptides, antigens, pharmaceutical drugs and cosmetical agents to cells and tissues.
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3.发明公开COMPOUNDS AND METHODS FOR MODULATING DESMOSOMAL CADHERIN-MEDIATED FUNCTIONS 审中-公开化合物和方法调制的桥粒钙粘蛋白介导的功能的
公开(公告)号：EP1366076A2
公开(公告)日：2003-12-03
申请号：EP01951873.7
申请日：2001-03-27
IPC分类号： C07K14/705
CPC分类号： C07K5/0808 , A61K38/00 , C07K5/1008 , C07K5/101 , C07K7/06 , C07K14/705 , C07K2319/00 , Y10S977/805
摘要： Modulating agents for inhibiting or enhancing desmosomal cadherin mediated cell adhesion are provided. The modulating agents comprise one or more of: a) a peptide sequence that is at least 50% identical to a desmosomal cadherin CAR sequence; b) a non-peptide mimetic of a desmosomal cadherin CAR sequence; c) a substance, such as an antibody or antigen-binding fragment thereof, that specifically binds a desmosomal cadherin CAR sequence; and/or d) a polynucleotide encoding a polypeptide that comprises a desmosomal cadherin CAR sequence or analogue thereof. Methods for using such modulating agents for modulating desmosomal cadherin-mediated cell adhesion in a variety of contexts are also provided.
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4.发明授权
公开(公告)号：EP0344040B1
公开(公告)日：1992-07-01
申请号：EP89401317.6
申请日：1989-05-11
CPC分类号： A61K9/5123 , A61K9/127 , A61K9/5161 , A61K47/51 , Y02A50/411 , Y10S977/783 , Y10S977/797 , Y10S977/805 , Y10S977/808 , Y10S977/829 , Y10S977/915 , Y10S977/918 , Y10T428/2989
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5.发明公开Vecteur particulaire utile notamment pour le transport de molécules à activité biologique et procédé pour sa préparation 失效特别地，用于实施生物活性分子合适的微粒载体系统和方法，用于其制备。
公开(公告)号：EP0344040A1
公开(公告)日：1989-11-29
申请号：EP89401317.6
申请日：1989-05-11
CPC分类号： A61K9/5123 , A61K9/127 , A61K9/5161 , A61K47/51 , Y02A50/411 , Y10S977/783 , Y10S977/797 , Y10S977/805 , Y10S977/808 , Y10S977/829 , Y10S977/915 , Y10S977/918 , Y10T428/2989
摘要： La présente invention concerne un vecteur particulaire caractérisé en ce qu'il comporte :
- un noyau hydrophile non liquide ;
- une première couche ou couronne de nature lipidique liée au noyau par des liaisons covalentes ;
- une seconde couche ou feuillet externe de composés amphiphiles liée à la première couche lipidique par des interactions hydrophobes.
Ce vecteur particulaire est utile notamment pour le transport des molécules à activités biologiques.-
6.发明公开PEPTIDES WHICH ENHANCE TRANSPORT OF AN ACTIVE AGENT ACROSS TISSUES AND COMPOSITIONS AND METHODS OF USING THE SAME 失效肽，其活性物质通过织物上的运输及提高成份和方法使用相同的
公开(公告)号：EP0981649A4
公开(公告)日：2003-05-02
申请号：EP98923466
申请日：1998-05-15
申请人： ELAN CORP PLC , CYTOGEN CORP
IPC分类号： C12N15/09 , A61K9/16 , A61K9/50 , A61K9/51 , A61K38/00 , A61K47/48 , A61K48/00 , A61P5/48 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N15/10 , C40B40/02 , G01N33/68 , A61K38/16 , C07H21/00 , C07K1/04
CPC分类号： C40B40/02 , A61K9/167 , A61K47/42 , A61K47/62 , A61K47/6937 , B82Y5/00 , C12N15/1037 , G01N33/68 , Y10S977/805
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公开(公告)号：EP0969863A4
公开(公告)日：2001-11-07
申请号：EP97941679
申请日：1997-09-18
申请人： UNIV TEXAS
发明人： SHIH CHIAHO , YUAN TA-TUNG
IPC分类号： A61K35/76 , A61K39/00 , A61K39/29 , A61P31/12 , C07K14/02 , C12N7/00 , A61K39/12 , C12N7/01 , C12N7/04 , C12N15/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/292 , C12N7/00 , C12N2730/10122 , C12N2730/10132 , C12N2730/10134 , Y10S977/802 , Y10S977/805 , Y10S977/915 , Y10S977/918
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8.发明公开PEPTIDES WHICH ENHANCE TRANSPORT OF AN ACTIVE AGENT ACROSS TISSUES AND COMPOSITIONS AND METHODS OF USING THE SAME 失效肽，其活性物质通过织物上的运输及提高成份和方法使用相同的
公开(公告)号：EP0981649A1
公开(公告)日：2000-03-01
申请号：EP98923466.1
申请日：1998-05-15
CPC分类号： C40B40/02 , A61K9/167 , A61K47/42 , A61K47/62 , A61K47/6937 , B82Y5/00 , C12N15/1037 , G01N33/68 , Y10S977/805
摘要： Targeting agents that are capable of permitting or facilitating transport of an active agent through a human or animal gastro-intestinal tissue. These targeting agents are peptides or their derivatives (e.g., fragments) and peptidomimetics thereof, and the nucleotide sequences coding for the peptides and derivatives. The targeting agents have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Therapeutic methods of administration, pharmaceutical compositions and formulations based on the targeting agent peptides are also provided. Preferably, the active agent is a drug or drug-containing nano- or microparticle.
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