公开(公告)号：EP2828297A1

公开(公告)日：2015-01-28

申请号：EP12726819.1

申请日：2012-05-10

申请人： Adocia

发明人： CHARVET, Richard ,  SOULA, Rémi ,  SOULA, Olivier

IPC分类号： C08B37/00 ,  A61K47/36

CPC分类号： C08B37/0021 ,  A61K47/36

摘要： The invention relates to an oligodextran selected from among dextrans having an average degree of polymerisation of less than 10, modified by at least one substituent having general formula (I): -R
1 -[[AA]-[R
2 ]
n ]
m .
The invention also relates to a pharmaceutical composition characterised in that it comprises an oligosaccharide according to the invention and an active principle is selected from the group containing proteins, glycoproteins, peptides and non-peptide therapeutic molecules.

公开(公告)号：EP2773675A1

公开(公告)日：2014-09-10

申请号：EP12797948.2

申请日：2012-11-02

申请人： Adocia

发明人： SOULA, Olivier ,  SOULA, Rémi ,  SOULA, Gérard

IPC分类号： C08B37/00 ,  A61K47/36 ,  C08L5/02 ,  A61K31/721 ,  A61K38/28

CPC分类号： C08B37/0021 ,  A61K9/0019 ,  A61K38/28 ,  A61K47/183 ,  A61K47/32 ,  C08L5/02

摘要： The invention relates to a composition in an aqueous solution, which includes insulin and at least one oligosaccharide, the mean polymerisation degree of which is from 3 to 13 and the polydispersity index Ip of which is higher than 1.0, said oligosaccharide comprising partially substituted carboxyl functional groups, the non-substituted carboxyl functional groups being salifiable.

公开(公告)号：EP2349338A2

公开(公告)日：2011-08-03

申请号：EP09740953.6

申请日：2009-09-28

申请人： Adocia

发明人： SOULA, Olivier ,  SOULA, Rémi ,  GAUDIER, Martin ,  SOULA, Gérard

IPC分类号： A61K47/36

CPC分类号： A61K9/0019 ,  A61K9/19 ,  A61K38/1825 ,  A61K38/185 ,  A61K38/1866 ,  A61K38/27 ,  A61K38/29 ,  A61K47/42 ,  A61K47/61

摘要： The invention relates to a complex consisting of a polysaccharide and an HPB, said polysaccharide consisting of (1,6), (1,4), (1,3), and/or (1,2) glycosidic bonds and functionalized by at least one salifiable or salified tryptophan derivative. The invention also relates to a pharmaceutical composition including a complex according to the invention and to the use of a polysaccharide, consisting of (1,6), (1,4), (1,3), and/or (1,2) glycosidic bonds and functionalized by at least one salifiable or salified tryptophan derivative, to prepare a pharmaceutical formulation of stable HPBs.

公开(公告)号：EP2288371A1

公开(公告)日：2011-03-02

申请号：EP09733038.5

申请日：2009-04-14

申请人： Adocia

发明人： SOULA, Rémi ,  SOULA, Olivier ,  SOULA, Gérard

IPC分类号： A61K38/18 ,  A61L24/10 ,  A61L27/24 ,  A61L27/46 ,  A61L27/52 ,  A61L27/54

CPC分类号： A61K38/1825 ,  A61K38/1858 ,  A61K38/1866 ,  A61K38/1875 ,  A61L24/10 ,  A61L27/24 ,  A61L27/46 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/414

摘要： The invention relates to an open implant constituting an osteogenic composition including at least: • an osteogenic growth factor, • a soluble cation salt that is at least divalent, and • an organic substrate • said organic substrate not including any demineralized bone matrix. In one embodiment, said implant is in freeze-dried form. The invention also relates to the preparation method thereof.

公开(公告)号：EP2066700A1

公开(公告)日：2009-06-10

申请号：EP07825188.1

申请日：2007-09-26

申请人： Adocia

发明人： SOULA, Rémi ,  SOULA, Gérard ,  SOULA Olivier

IPC分类号： C08B37/02 ,  A61K47/36 ,  A61K31/721

CPC分类号： A61K31/721 ,  C08B37/0021

摘要： The invention relates to a dextran functionalized with at least one hydrophobic alpha-amino acid residue, wherein said alpha-amino acid is grafted or linked to the dextran by a linker arm and a function. The term “hydrophobic amino acid residue” is intended to mean the product of coupling between the amine of the amino acid and an acid carried by the linker arm, wherein said dextran is amphiphilic at neutral pH. In one embodiment, the hydrophobic amino acid is selected from tryptophan derivatives such as tryptophan, tryptophanol, tryptophanamide and 2-indoleethylamine, and alkali cation salts thereof. The present invention also relates to a pharmaceutical composition containing one of the dextrans according to the invention.

公开(公告)号：EP2533812A2

公开(公告)日：2012-12-19

申请号：EP11710319.2

申请日：2011-02-09

申请人： Adocia

发明人： CHARVET, Richard ,  SOULA, Rémi ,  SOULA, Olivier

IPC分类号： A61K47/36 ,  C08B11/12 ,  C08B37/00

CPC分类号： A61K47/36 ,  C08B11/12 ,  C08B11/14 ,  C08B37/0018 ,  C08B37/0021 ,  C08B37/0045 ,  C08B37/0072 ,  C08B37/0084

摘要： The present invention relates to novel anionic polysaccharide derivatives partially functionalised by at least two vicinal hydrophobic groups, said identical or different hydrophobic groups being supported by an at least trivalent radical or spacer. The invention also relates to methods for synthesising same. The invention further relates to the use of functionalised polysaccharides according to the invention for preparing pharmaceutical compositions including one of the polysaccharides according to the invention and at least one active principle.

公开(公告)号：EP2516473A1

公开(公告)日：2012-10-31

申请号：EP10814709.1

申请日：2010-12-23

申请人： Adocia

发明人： CHARVET, Richard ,  SOULA, Rémi ,  SOULA, Olivier

IPC分类号： C08B37/00 ,  A61K31/00 ,  A61K47/36 ,  C08B1/00

摘要： The present invention relates to novel anionic polysaccharides functionalised by at least one hydrophobic acid derivative. Said novel anionic polysaccharides comprising hydrophobic groups have good biocompatibility and the hydrophobicity thereof can be easily modulated with no adverse effects on biocompatibility or stability. The invention also relates to a synthesis method suitable for obtaining said polysaccharides and to pharmaceutical compositions including same.

公开(公告)号：EP2321358A1

公开(公告)日：2011-05-18

申请号：EP09737009.2

申请日：2009-08-07

申请人： Adocia

发明人： SOULA, Rémi ,  SOULA, Gérard ,  SOULA, Olivier

IPC分类号： C08B37/00 ,  C08B37/04 ,  C08B37/08 ,  C08B37/18 ,  A61K47/36

CPC分类号： C08B37/0018 ,  A61K47/36 ,  C08B37/00 ,  C08B37/0006 ,  C08B37/0009 ,  C08B37/0021 ,  C08B37/0024 ,  C08B37/0045 ,  C08B37/0054 ,  C08B37/0057 ,  C08B37/0072 ,  C08B37/0084

摘要： The invention relates to novel polysaccharide derivatives predominately containing glycosidic bonds of the (1,4), (1,3) and/or (1,2) type, and functionalised by at least one tryptophan derivative. The invention also relates to methods for the synthesis thereof, to the uses thereof as a pharmaceutical carrier, and to pharmaceutical compositions containing the same.

公开(公告)号：EP2007816A1

公开(公告)日：2008-12-31

申请号：EP07731267.6

申请日：2007-04-06

申请人： Adocia

发明人： SOULA, Gérard ,  SOULA, Rémi ,  SOULA, Olivier

IPC分类号： C08B37/00 ,  C08B15/06 ,  C08B37/02 ,  C08B37/04 ,  C08B37/08 ,  C08B37/14 ,  A61K47/36

CPC分类号： A61K9/0019 ,  A61K47/36 ,  C08B11/20 ,  C08B15/06 ,  C08B37/00 ,  C08B37/0021 ,  C08B37/003 ,  C08B37/0045 ,  C08B37/0069 ,  C08B37/0072 ,  C08B37/0084

摘要： The invention concerns a dextran and/or dextran derivative bifunctionalized by at least one imidazolyl radical (Im) and at least one hydrophobic group (Hy), said radical and group being each, identical and/or different, and, grafted or bound to the dextran and/or dextran derivative by one or more linker arms R, Ri or Rh and functions F, Fi or Fh as well as pharmaceutical compositions comprising one of said dextrans and at least one active principle.

公开(公告)号：EP1940448A2

公开(公告)日：2008-07-09

申请号：EP06808894.7

申请日：2006-09-26

申请人： Adocia

发明人： DUBREUCQ, Guy ,  DAHRI-CORREIA, Latifa ,  CORREIA, José ,  DURACHER, David ,  SOULA, Rémi ,  SOULA, Olivier ,  SOULA, Gérard

IPC分类号： A61K38/18 ,  A61K47/36 ,  A61P17/02

CPC分类号： A61K47/36 ,  A61K38/1858

摘要： The invention concerns novel platelet-derived growth factor (PDGF) complexes associated with amphiphilic polymers for enhancing the physical and chemical in vitro and in vivo stability of the therapeutic protein for pharmaceutical applications. The invention also concerns a method for preparing the PDGF-amphiphilic polymer complex characterized in that it consists in preparing said polymer/PDGF-BB complex in an aqueous medium and in the absence of organic solvent likely to cause denaturation of the protein and the use of said PDGF-amphiphilic polymer complex for preparing a therapeutic wound-healing composition for topically treating ulcers.