公开(公告)号：EP2054053A1

公开(公告)日：2009-05-06

申请号：EP07801624.3

申请日：2007-08-13

申请人： AiCuris GmbH & Co. KG

发明人： HEIMBACH, Dirk ,  TERSTEEGEN, Adrian ,  THEDE, Kai ,  WELKER, Reinhold ,  FAST, Beate ,  PAESSENS, Arnold ,  DITTMER, Frank ,  SCHOHE-LOOP, Rudolf ,  HARRENGA, Axel ,  HILLISCH, Alexander ,  HENNINGER, Kerstin ,  HÜBSCH, Walter ,  BAUSER, Marcus ,  PAULSEN, Daniela ,  BIRKMANN, Alexander ,  BRETSCHNEIDER, Thomas ,  FISCHER, Reiner ,  GRESCHAT, Susanne ,  URBAN, Andreas ,  WILDUM, Steffen

IPC分类号： A61K31/343 ,  C07D307/94 ,  C07D405/12 ,  C07D407/10 ,  C07D491/10 ,  C07D493/10 ,  C07D495/10

CPC分类号： C07D307/94 ,  C07D405/12 ,  C07D407/10 ,  C07D491/10 ,  C07D493/10 ,  C07D495/10

摘要： The present invention relates to novel substituted spirotetronic acids (I) in which R1 and R2, together with the carbon atom to which they are bonded, form a group of the formula (1), (2), (3) or (4), where * is the carbon atom to which R1 and R2 are bonded, to processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular of retroviral disorders, in people and/or animals.

公开(公告)号：EP2278965A2

公开(公告)日：2011-02-02

申请号：EP09722891.0

申请日：2009-03-14

申请人： AiCuris GmbH & Co. KG

发明人： SCHOHE-LOOP, Rudolf ,  WELKER, Reinhold ,  PAESSENS, Arnold ,  BAUSER, Marcus ,  STOLL, Friedrike ,  DITTMER, Frank ,  HENNINGER, Kerstin ,  PAULSEN, Daniela ,  LANG, Dieter

IPC分类号： A61K31/4155 ,  C07D231/10 ,  A61P31/18

CPC分类号： C07D231/14 ,  A61K31/4155 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06 ,  C07D417/06 ,  C07D451/06 ,  C07D491/08 ,  C07D498/08

摘要： The present invention relates to novel substituted pyrazolamides, methods for the production thereof, use thereof for treating and/or preventing diseases, and use thereof for producing pharmaceuticals for treating and/or preventing diseases, particularly retroviral diseases, in humans and/or animals.

公开(公告)号：EP2278965B1

公开(公告)日：2013-11-13

申请号：EP09722891.0

申请日：2009-03-14

申请人： AiCuris GmbH & Co. KG

发明人： SCHOHE-LOOP, Rudolf ,  WELKER, Reinhold ,  PAESSENS, Arnold ,  BAUSER, Marcus ,  STOLL, Friedrike ,  DITTMER, Frank ,  HENNINGER, Kerstin ,  PAULSEN, Daniela ,  LANG, Dieter

IPC分类号： A61K31/4155 ,  C07D231/10 ,  A61P31/18

CPC分类号： C07D231/14 ,  A61K31/4155 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06 ,  C07D417/06 ,  C07D451/06 ,  C07D491/08 ,  C07D498/08

公开(公告)号：EP1356287B1

公开(公告)日：2008-09-10

申请号：EP01991820.0

申请日：2001-12-11

申请人： AiCuris GmbH & Co. KG

发明人： PAESSENS, Arnold ,  DITTMER, Frank

IPC分类号： G01N33/50

CPC分类号： G01N33/505 ,  G01N2333/16

摘要： The invention relates to a replication assay for detecting anti-virally active inhibitors in the form of a single-well assay. Said assay consists of a combination of a natural virus isolation agent, suspended target cells and a cell culture medium containing foetal calf serum, whereby the concentration of the foetal calf serum is less than 5 % by volume.