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公开(公告)号：EP2448610A2
公开(公告)日：2012-05-09
申请号：EP10794384.7
申请日：2010-07-01
发明人： PARK, Ki-Dong , JOUNG, Yoon-Ki , PARK, Kyung-Min
CPC分类号： A61L27/52 , A61K9/0024 , A61K47/42 , A61L27/54 , A61L2300/252 , A61L2300/256 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/43 , A61L2300/602 , A61L2400/06
摘要： Disclosed are in situ-forming injectable hydrogel and medical uses thereof. In the in situ-forming injectable hydrogel two or more homogeneous or heterogeneous polymers are bonded to each other by a dehydrogenation reaction between phenol or aniline moieties on adjacent polymers, wherein a polymer backbone is grafted with a phenol or aniline moiety using a linker. In contrast to conventional hydrogel, the in situ-forming injectable hydrogel is superior in terms of in vivo stability and mechanical strength thanks to the introduction of a water-soluble polymer as a linker which leads to an improvement in the reactivity of phenol or aniline moieties. Having the advantage of superior bio stability and mechanical strength, the hydrogel finds a variety of applications in the biomedical field.
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2.发明公开IN SITU-FORMING HYDROGEL FOR TISSUE ADHESIVES AND BIOMEDICAL USE THEREOF 有权MADE IN原位水凝胶组织粘合剂和生物医药它们的用途
公开(公告)号：EP2473210A2
公开(公告)日：2012-07-11
申请号：EP10813940.3
申请日：2010-09-02
发明人： PARK, Ki-Dong , JOUNG, Yoon-Ki , PARK, Kyung-Min , LIH, Eu-Gene
CPC分类号： A61L24/0042 , A61L24/0015 , A61L24/0031 , A61L24/046 , A61L27/18 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/256 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2300/43 , A61L2300/602 , C08L71/02
摘要： Disclosed herein are an in situ-forming, bioadhesive hydrogel and the medical uses thereof. Being formed by in situ crosslinking through an enzymatic reaction, the hydrogel has an advantage over conventional bioadhesive hydrogels in terms of biocompatibility. In addition, the in situ-forming bioadhesive hydrogel has excellent biocompatibility and mechanical strength and has excellent tissue adhesiveness thanks to modification with/without dopa derivatives. The hydrogel finds a variety of applications in the biomedical field, including bioadhesives or hemostats, implant substances for tissue regeneration and augmentation, carriers for delivering biologically active materials or drugs, etc.
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3.发明授权IN SITU-FORMING HYDROGEL FOR TISSUE ADHESIVES AND BIOMEDICAL USE THEREOF 有权MADE IN原位水凝胶组织粘合剂和生物医药它们的用途
公开(公告)号：EP2473210B1
公开(公告)日：2016-06-01
申请号：EP10813940.3
申请日：2010-09-02
发明人： PARK, Ki-Dong , JOUNG, Yoon-Ki , PARK, Kyung-Min , LIH, Eu-Gene
CPC分类号： A61L24/0042 , A61L24/0015 , A61L24/0031 , A61L24/046 , A61L27/18 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/256 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2300/43 , A61L2300/602 , C08L71/02
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公开(公告)号：EP2448610B1
公开(公告)日：2016-01-06
申请号：EP10794384.7
申请日：2010-07-01
发明人： PARK, Ki-Dong , JOUNG, Yoon-Ki , PARK, Kyung-Min
CPC分类号： A61L27/52 , A61K9/0024 , A61K47/42 , A61L27/54 , A61L2300/252 , A61L2300/256 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/416 , A61L2300/43 , A61L2300/602 , A61L2400/06
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