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    Methods and kits for detecting heparin/platelet factor 4 antibodies
    1.
    发明公开
    Methods and kits for detecting heparin/platelet factor 4 antibodies 审中-公开
    用于检测肝素/血小板因子4抗体的方法和试剂盒

    公开(公告)号：EP2144064A2

    公开(公告)日：2010-01-13

    申请号：EP09171902.1

    申请日：2005-10-04

    申请人： Akers Biosciences, Inc.

    发明人： Milunic, David ,  Andrelczyk, Susan

    IPC分类号： G01N33/543

    CPC分类号： G01N33/6863 ,  B01L3/5023 ,  B01L2200/16 ,  B01L2300/0681 ,  B01L2400/0683 ,  G01N33/54313 ,  G01N33/564 ,  G01N33/6893 ,  G01N33/86 ,  G01N2333/522 ,  G01N2400/40 ,  G01N2800/222

    摘要： Methods for determining the presence of heparin/platelet factor 4 antibodies in a sample suspected to contain heparin/platelet factor 4 antibodies are provided, along with apparatus suitable for performing the methods. The method depends upon a color visualization indicating the presence or absence of heparin/platelet factor 4 antibodies in the sample. Preferred methods comprise contacting the sample with particles being complexed to platelet factor 4 (PF4) and which particle-complexed PF4 reacts specifically with heparin/platelet factor 4 antibodies, passing the sample/particle mixture through a filter, and then analyzing the color of the filtrate. The presence of heparin/platelet factor 4 antibodies in the sample is established where the color of the filtrate is substantially different from the color of the receptor-bearing particles.

    摘要翻译： 提供了用于确定怀疑含有肝素/血小板因子4抗体的样品中肝素/血小板因子4抗体的存在的方法，以及适于实施所述方法的装置。 该方法取决于指示样品中存在或不存在肝素/血小板因子4抗体的颜色可视化。 优选的方法包括使样品与与血小板因子4（PF4）复合的颗粒接触，并使颗粒复合的PF4与肝素/血小板因子4抗体特异性反应，使样品/颗粒混合物通过过滤器，然后分析 滤液。 建立样品中肝素/血小板因子4抗体的存在，其中滤液的颜色与带有受体的颗粒的颜色明显不同。