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    ANTI-ACTH ANTIBODIES AND USE THEREOF
    5.
    发明公开
    ANTI-ACTH ANTIBODIES AND USE THEREOF 审中-公开
    抗议者抗议者在维尔多·达文

    公开(公告)号：EP3107569A1

    公开(公告)日：2016-12-28

    申请号：EP15752472.9

    申请日：2015-02-20

    申请人： Alder Biopharmaceuticals, Inc.

    发明人： FELDHAUS, Andrew, Lawrence ,  GARCIA-MARTINEZ, Leon ,  DUTZAR, Benjamin, H. ,  ALLISON, Daniel, S. ,  ANDERSON, Katie, Olson ,  OJALA, Ethan, Wayne ,  FAN, Pei ,  KARASEK, Charlie ,  MULLIGAN, Jenny ,  SCALLEY-KIM, Michelle ,  STEWART, Erica ,  SMITH, Jeffrey, T. L. ,  LATHAM, John, A.

    IPC分类号： A61K39/00 ,  C12P21/08 ,  C07K16/00

    CPC分类号： C07K16/26 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/62 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92

    摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for ACTH. Another embodiment of this invention relates to the antibodies binding fragments thereof described herein, comprising the sequences of the VH, VL and/or CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-ACTH antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention further contemplates methods of making said anti-ACTH antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-ACTH antibodies and binding fragments thereof for the diagnosis, assessment, prevention and treatment of diseases and disorders associated with ACTH, such as Cushing's Disease, Cushing's Syndrome, Parkinson's disease, obesity, diabetes, sleep disorders depression, anxiety disorders, cancer, muscle atrophy, hypertension, hyperinsulinemia, cognitive dysfunction, Alzheimer's disease, galactorrhea, stress related conditions, cardiac conditions, metabolic syndrome, hyperaldosteronism, Conn's syndrome and familial hyperaldosteronism.

    摘要翻译： 本发明涉及对ACTH具有结合特异性的抗体及其片段。 本发明的另一个实施方案涉及本文所述的其抗体结合片段，其包含本文所述的VH，VL和/或CDR多肽的序列，以及编码它们的多核苷酸。 本发明还考虑了抗ACTH抗体和与一个或多个功能或可检测部分缀合的结合片段的缀合物。 本发明进一步考虑制备所述抗ACTH抗体及其结合片段的方法。 本发明的实施方案还涉及抗ACTH抗体及其结合片段用于诊断，评估，预防和治疗与ACTH相关的疾病和病症如库兴氏病，库兴综合征，帕金森病，肥胖症，糖尿病， 睡眠障碍抑郁症，焦虑症，癌症，肌肉萎缩，高血压，高胰岛素血症，认知功能障碍，阿尔茨海默病，乳溢症，压力相关病症，心脏病症，代谢综合征，醛固酮增多症，康氏综合征和家族性醛固酮增多症。

    HUMANIZED ANTI-ACTH ANTIBODIES AND USE THEREOF
    8.
    发明公开
    HUMANIZED ANTI-ACTH ANTIBODIES AND USE THEREOF 审中-公开
    人源化抗ACTH抗体及其用途

    公开(公告)号：EP3233916A2

    公开(公告)日：2017-10-25

    申请号：EP15871177.0

    申请日：2015-12-18

    申请人： Alder Biopharmaceuticals, Inc.

    发明人： FELDHAUS, Andrew, L. ,  GARCIA-MARTINEZ, Leon, F. ,  DUTZAR, Benjamin, H. ,  ALLISON, Daniel, S. ,  ANDERSON, Katie ,  OJALA, Ethan, W. ,  FAN, Pei ,  KARASEK, Charlie ,  MULLIGAN, Jenny ,  MITCHELL, Danielle ,  MCNEILL, Patricia Dianne ,  SCALLEY-KIM, Michelle ,  STEWART, Erica ,  SMITH, Jeffrey, T.L. ,  LATHAM, John

    IPC分类号： C07K16/26 ,  C07K16/42

    CPC分类号： C07K16/26 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/4241 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92

    摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for ACTH. Embodiments of this invention relate to the binding fragments of antibodies described herein, comprising the sequences of the VH, VL and/or CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates anti-ACTH antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention further contemplates methods of making said anti-ACTH antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-ACTH antibodies and binding fragments thereof for the diagnosis, assessment, prevention and treatment of diseases and disorders associated with ACTH, such as CAH, FGD, Cushing's Disease, Cushing's Syndrome, Parkinson's disease, obesity, diabetes, sleep disorders, depression, anxiety disorders, cancer, muscle atrophy, hypertension, hyperinsulinemia, cognitive dysfunction, Alzheimer's disease, galactorrhea, stress related conditions, cardiac conditions, metabolic syndrome, hyperaldosteronism, Conn's syndrome and familial hyperaldosteronism.

    摘要翻译： 本发明涉及对ACTH具有结合特异性的抗体及其片段。 本发明的实施方案涉及本文描述的抗体的结合片段，其包含本文所述的V H，V L和/或CDR多肽的序列和编码它们的多核苷酸。 本发明还涵盖与一个或多个功能或可检测部分缀合的抗ACTH抗体及其结合片段。 本发明进一步考虑了制备所述抗ACTH抗体及其结合片段的方法。 本发明的实施方案还涉及抗ACTH抗体及其结合片段用于诊断，评估，预防和治疗与ACTH相关的疾病和病症，例如CAH，FGD，库欣氏病，库欣综合征，帕金森病， 肥胖症，糖尿病，睡眠障碍，抑郁症，焦虑症，癌症，肌肉萎缩症，高血压，高胰岛素血症，认知功能障碍，阿尔茨海默病，溢乳，压力相关病症，心脏病，代谢综合征，醛固酮增多症，康恩综合征和家族性醛固酮过多症。