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1.发明公开USE OF ANTI-PACAP ANTIBODIES AND ANTIGEN BINDING FRAGMENTS THEREOF FOR TREATMENT, PREVENTION, OR INHIBITION OF PHOTOPHOBIA 审中-公开使用抗PACAP抗体和其抗原结合片段治疗，预防或抑制PHOTOPHOBIA
公开(公告)号：EP3283168A1
公开(公告)日：2018-02-21
申请号：EP16780943.3
申请日：2016-04-15
发明人： ALLISON, Daniel S. , HENDRIX, Katherine Lee , OJALA, Ethan Wayne , FAN, Pei , SMITH, Jeffrey T.L. , LATHAM, John , KARASEK, Charlie , MULLIGAN, Jenny , SCALLEY-KIM, Michelle , STEWART, Erica , RUBIN, Vanessa Lisbeth , BILLGREN, Jens J. , KUBURAS, Adisa , MASON, Bianca , SOWERS, Levi P. , RUSSO, Andrew F. , LOOMIS, Maria-Cristina , DUTZAR, Benjamin H. , GARCIA-MARTINEZ, Leon
IPC分类号： A61P25/06 , A61K39/395
CPC分类号： C07K16/26 , A61K39/3955 , A61K39/39566 , A61K45/06 , A61K49/0004 , A61K49/0008 , A61K2039/505 , C07K16/4241 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/76 , C07K2317/92 , G01N33/5088 , G01N33/74 , G01N2333/5757 , Y02A50/383
摘要： This invention relates to methods of screening for anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof, for potential use in treating or preventing PACAP-associated photophobia or light aversion, and therapeutic compositions containing and methods of using anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof.
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2.发明公开
公开(公告)号：EP3283169A1
公开(公告)日：2018-02-21
申请号：EP16780946.6
申请日：2016-04-15
发明人： ALLISON, Daniel S. , HENDRIX, Katherine Lee , OJALA, Ethan Wayne , FAN, Pei , SMITH, Jeffrey T.L. , LATHAM, John , KARASEK, Charlie , MULLIGAN, Jenny , SCALLEY-KIM, Michelle , STEWART, Erica , RUBIN, Vanessa Lisbeth , BILLGREN, Jens J. , KUBURAS, Adisa , MASON, Bianca , SOWERS, Levi P. , RUSSO, Andrew F. , LOOMIS, Maria-Cristina , DUTZAR, Benjamin H. , GARCIA-MARTINEZ, Leon
IPC分类号： A61P25/06 , A61K39/395
CPC分类号： C07K16/26 , A61K39/3955 , A61K39/39566 , A61K45/06 , A61K49/0004 , A61K49/0008 , A61K2039/505 , C07K16/4241 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/76 , C07K2317/92 , G01N33/5088 , G01N33/74 , G01N2333/5757 , Y02A50/383
摘要： This invention relates to methods of screening for anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof, for potential use in treating or preventing PACAP-associated photophobia or light aversion, and therapeutic compositions containing and methods of using anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof.
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公开(公告)号：EP2709663B1
公开(公告)日：2019-03-20
申请号：EP12790022.3
申请日：2012-05-21
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公开(公告)号：EP2709662B1
公开(公告)日：2019-07-31
申请号：EP12788717.2
申请日：2012-05-21
发明人： RUSSO, Andrew F. , KAISER, Eric A. , RECOBER, Ana , KUBURAS, Adisa , RADDANT, Ann C. , KOVACEVICH, Brian Robert , LATHAM, John A. , SMITH, Jeffrey T.L. , GARCIA-MARTINEZ, Leon F.
IPC分类号： A61K39/395 , A61K48/00 , A61K38/16 , A61K31/7088 , A61P1/12 , C07K16/26 , A61K45/06 , A61K39/00
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5.发明公开USE OF ANTI-CGRP OR ANTI-CGRP-R ANTIBODIES OR ANTIBODY FRAGMENTS TO TREAT OR PREVENT CHRONIC AND ACUTE FORMS OF DIARRHEA 审中-公开抗CGRP或抗CGRP-R抗体或抗体片段治疗慢性治疗或预防与急性腹泻使用形式
公开(公告)号：EP2709662A1
公开(公告)日：2014-03-26
申请号：EP12788717.2
申请日：2012-05-21
发明人： RUSSO, Andrew F. , KAISER, Eric A. , RECOBER, Ana , KUBURAS, Adisa , RADDANT, Ann C. , KOVACEVICH, Brian Robert , LATHAM, John A. , SMITH, Jeffrey T.L. , GARCIA-MARTINEZ, Leon F.
IPC分类号： A61K39/395 , A61K48/00 , A61K38/16 , A61K31/7088 , A61P1/12
CPC分类号： A61K45/06 , A61K2039/505 , C07K16/26 , C07K2317/24 , C07K2317/76 , Y02A50/487
摘要： The present invention is directed to methods for treating diarrhea, both chronic or acute forms, by the administration of a therapeutically or prophylactically effective amount of antibodies and fragments thereof having binding specificity for CGRP. In particular the methods prevent or reduce diarrhea in conditions or treatments resulting in elevated CGRP levels, e.g., in the GI tract (colon) that are associated with diarrhea and/or improper electrolyte and fluid excretion from the bowel or urinary system. More specifically, this invention relates to treatments using the anti-CGRP antibodies and fragments described herein, and binding fragments thereof.
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