公开(公告)号：EP1835857A1

公开(公告)日：2007-09-26

申请号：EP06718051.3

申请日：2006-01-11

申请人： ALZA CORPORATION

发明人： AMERI, Mahmound ,  CORMIER, Michel, J.N. ,  MAA, Yuh-fun

IPC分类号： A61B17/20 ,  A61K9/28 ,  A61M37/00

CPC分类号： A61K9/0021 ,  A61B17/205 ,  A61M37/0015 ,  A61M2037/0046 ,  A61M2037/0061

摘要： The invention provides for a formulation for coating one or more microprojections using a non- volatile counterion to improve solubility of a biologically active agent. The invention also includes formulations having a volatile counterion to reduce the solubility of a portion of the biologically active agent.

公开(公告)号：EP1737434A2

公开(公告)日：2007-01-03

申请号：EP05725916.0

申请日：2005-03-18

申请人： ALZA CORPORATION

发明人： AMERI, Mahmoud ,  CORMIER, Michel, J.N. ,  MAA, Yuh-Fun ,  DADDONA, Peter ,  GALE, Robert, M.

IPC分类号： A61K9/70

CPC分类号： A61K9/0021 ,  A61K31/445 ,  A61M37/0015 ,  A61M2037/0023

摘要： An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the fentanyl-based agent is contained in a biocompatible coating that is applied to the microprojection member. In a further embodiment, the delivery system includes a gel pack having a fentanyl-based agent­containing hydrogel formulation that is disposed on the microprojection member after application to the skin of a patient. In an alternative embodiment, the fentanyl-based agent is contained in both the coating and the hydrogel formulation.

摘要翻译： 一种用于透皮递送生物活性剂的设备和方法，该设备和方法包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括适于刺穿角质层进入下面的表皮层的多个微突出物（或其阵列） 表皮和真皮层。 在一个实施方案中，基于芬太尼的药剂被包含在施用于微喷射体元件的生物相容涂层中。 在进一步的实施方案中，递送系统包括具有基于芬​​太尼的药剂的含水凝胶制剂的凝胶组合物，其在施用于患者皮肤之后置于微喷射体构件上。 在另一个实施方案中，基于芬太尼的试剂包含在包衣和水凝胶制剂中。

公开(公告)号：EP1643918A1

公开(公告)日：2006-04-12

申请号：EP04756609.6

申请日：2004-07-01

申请人： ALZA CORPORATION

发明人： CORMIER, Michel, J.N. ,  MATRIANO, James ,  JOHNSON, Juanita, A. ,  YOUNG, Wendy, A. ,  DADDONA, Peter E.

IPC分类号： A61B17/20

CPC分类号： A61M37/0015 ,  A61B17/205 ,  A61K9/0021 ,  A61M2037/0023 ,  A61M2037/0046

摘要： Microprojection members (10) having a reservoir containing an antigenic agent and methods of using such members to vaccinate mammals (e.g., humans) are disclosed. The microprojection members are used to transdermally deliver an antigenic agent (e.g., a vaccine antigen) with substantially reduced skin reactions. This is achieved by delivering an induction amount and thereafter delivering one or more subsequent booster amounts. The induction amount is relatively larger than the booster amount. This technology has broad applicability for a wide variety of therapeutic vaccines to improve efficacy and convenience of use.

公开(公告)号：EP2001453A2

公开(公告)日：2008-12-17

申请号：EP07753418.8

申请日：2007-03-15

申请人： ALZA Corporation

发明人： AMERI, Mahmoud ,  CORMIER, Michel, J.N. ,  MAA, Yuh-Fun ,  KAMBERI, Marika ,  DADDONA, Peter

IPC分类号： A61K9/70

CPC分类号： A61K9/0021 ,  A61K38/29 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0061

摘要： An apparatus and method for transdermally delivering a biologically active agent to prevent or treat osteopenia, comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.

公开(公告)号：EP1706176A2

公开(公告)日：2006-10-04

申请号：EP04795994.5

申请日：2004-10-21

申请人： ALZA CORPORATION

发明人： CHAN, Keith, T. ,  CORMIER, Michel, J.N. ,  LIN, WeiQi

IPC分类号： A61N1/30

CPC分类号： A61M37/0092 ,  A61K9/0021 ,  A61K31/4172 ,  A61K38/00 ,  A61K2039/54 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046

摘要： An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers, a formulation containing the biologically active agent and an oscillation inducing device. In one embodiment, the biologically active agent is contained in a biocompatible coating that is applied to the microprojection member. In a further embodiment, the delivery system includes a gel pack having an agent-containing hydrogel formulation that is disposed on the microprojection member after application to the skin of a patient. In an alternative embodiment, the biologically active agent is contained in both the coating and the hydrogel formulation.

公开(公告)号：EP1575570A2

公开(公告)日：2005-09-21

申请号：EP03816725.0

申请日：2003-08-08

申请人： ALZA CORPORATION

发明人： MAA, Yuh-Fun ,  CORMIER, Michel, J.N. ,  MATRIANO, James ,  LIN, Weiqi

IPC分类号： A61K9/70 ,  A61M37/00 ,  A61K47/10 ,  A61K47/20 ,  A61K47/26 ,  A61B17/20 ,  A61K47/18

CPC分类号： A61K47/26 ,  A61B17/205 ,  A61K9/0021 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K47/10 ,  A61K47/186 ,  A61K47/20 ,  A61K2039/54 ,  C12N2760/16134

摘要： A device and method are provided for percutaneous transdermal delivery of a immunologically active agent. The agent is mixed with appropriate surfactants and dissolved in water to form an aqueous coating solution having the appropriate concentration for coating extremely tiny skin piercing elements. The coating solution is applied to the skin piercing elements using known coating techniques and then dried. The device is applied to the skin of a living animal, causing the microprotrusions to pierce the stratum corneum and deliver a immunologically effective dose of the immunologically active agent to the animal.

公开(公告)号：EP1744683B1

公开(公告)日：2016-03-16

申请号：EP05727716.2

申请日：2005-03-18

申请人： Alza Corporation

发明人： AMERI, Mahmoud ,  CORMIER, Michel, J.N. ,  MAA, Yuh-Fun ,  KAMBERI, Marika ,  DADDONA, Peter

IPC分类号： A61K38/29 ,  A61K9/00 ,  A61K47/12 ,  A61K47/18 ,  A61K47/26 ,  A61M37/00

CPC分类号： A61K38/29 ,  A61K9/0021 ,  A61K47/12 ,  A61K47/183 ,  A61K47/26 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0061

公开(公告)号：EP1858584A2

公开(公告)日：2007-11-28

申请号：EP06735974.5

申请日：2006-02-24

申请人： Alza Corporation

发明人： CORMIER, Michel, J.N. ,  PADMANABHAN, Rama, V.

IPC分类号： A61N1/30 ,  A61N1/32

CPC分类号： A61N1/30 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/0448 ,  A61N1/325

摘要： A transdermal electrotransport drug delivery system having reduced potential for abuse. The system uses ion barrier (112, 124, 130, 140, 162, 168), preferentially ion exchange material to separate the drug (110, 122, 136, 148, 154, 170) from an antagonist and provides for the release of the antagonist (116, 128, 132, 138, 164) with the agonist when the system is subject to abuse. In a preferred embodiment, the barrier has a weak area which breaks when under stress or placed in solvent. In another preferred embodiment, the barrier is a dialysis membrane.

公开(公告)号：EP1744683A2

公开(公告)日：2007-01-24

申请号：EP05727716.2

申请日：2005-03-18

申请人： ALZA CORPORATION

发明人： AMERI, Mahmoud ,  CORMIER, Michel, J.N. ,  MAA, Yuh-Fun ,  KAMBERI, Marika ,  DADDONA, Peter

IPC分类号： A61B17/20

CPC分类号： A61K38/29 ,  A61K9/0021 ,  A61K47/12 ,  A61K47/183 ,  A61K47/26 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0061

摘要： An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (30) (or system) that includes a plurality of microprojections (32) (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating (35) that is applied to the microprojection member.

公开(公告)号：EP1680178A2

公开(公告)日：2006-07-19

申请号：EP04795995.2

申请日：2004-10-21

申请人： ALZA CORPORATION

发明人： SUBRAMONY, Janardhanan ,  PHIPPS, Joseph, B. ,  CORMIER, Michel, J.N. ,  WIDERA, Georg

IPC分类号： A61N1/00

CPC分类号： A61B17/205 ,  A61B2017/00765 ,  A61K9/0021 ,  A61M37/0015 ,  A61M2037/0023 ,  A61N1/30

摘要： A system and method for trandermally delivering a vaccine to a patient including an iontophoresis delivery device having a donor electrode, a Counter electrode, and electric circuitry for supplying iontophoresis energy to the electrodes, and a non-electroactive microprojection member having a plurality of stratum corneum-piercing microprojections extending therefrom. The vaccine can be contained in a hydrogel formulation in an agent reservoir disposed proximate the donor electrode, in a biocompatible coating that is disposed on the microprojections or in both.