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15 条记录 (耗时 0.041 秒)

    COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES
    1.
    发明公开
    COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES 有权
    成分和方法，并使用非天然氨基酸和多肽

    公开(公告)号：EP1968635A2

    公开(公告)日：2008-09-17

    申请号：EP06848566.3

    申请日：2006-12-13

    申请人： Ambrx, Inc.

    发明人： MIAO, Zhenwei ,  LIU, Junjie ,  NORMAN, Thea

    IPC分类号： A61K39/395 ,  C12P21/06

    CPC分类号： C07K2/00 ,  C07C229/42 ,  C07K1/006

    摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.

    HYBRID SUPPRESSOR TRNA FOR VERTEBRATE CELLS
    6.
    发明授权
    HYBRID SUPPRESSOR TRNA FOR VERTEBRATE CELLS 有权
    HYBRID下HOUR-tRNA的电涡流动物细胞

    公开(公告)号：EP2061878B1

    公开(公告)日：2014-01-08

    申请号：EP07837971.6

    申请日：2007-09-07

    申请人： Ambrx, Inc.

    发明人： TIAN, Feng ,  NORMAN, Thea ,  CHU, Stephanie

    IPC分类号： C12N5/10 ,  C07H21/02 ,  C07H21/04 ,  C12P21/02

    CPC分类号： C12P21/02 ,  C12N9/93 ,  C12N15/11

    摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided. The present invention provides vertebrate cells with translation components, e.g., pairs of orthogonal aminoacyl-tRNA synthetases (O-RSs) and orthogonal tRNA's (O-tRNA's) and individual components thereof, that are used in vertebrate protein biosynthetic machinery to incorporate an unnatural amino acid in a growing polypeptide chain, in a vertebrate cell.

    SITE SPECIFIC INCORPORATION OF NON-NATURAL AMINO ACIDS BY VERTEBRATE CELLS
    7.
    发明授权
    SITE SPECIFIC INCORPORATION OF NON-NATURAL AMINO ACIDS BY VERTEBRATE CELLS 有权
    位置特定INCORPORATION非天然氨基酸插入涡动物细胞

    公开(公告)号：EP2064316B1

    公开(公告)日：2012-01-25

    申请号：EP07837970.8

    申请日：2007-09-07

    申请人： Ambrx, Inc.

    发明人： TIAN, Feng ,  NORMAN, Thea ,  CHU, Stephanie

    IPC分类号： C12N5/02

    CPC分类号： C12N9/93 ,  C12P21/02

    摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided.

    HYBRID SUPPRESSOR TRNA FOR VERTEBRATE CELLS
    8.
    发明公开
    HYBRID SUPPRESSOR TRNA FOR VERTEBRATE CELLS 有权
    杂交细胞的杂交抑制剂TRNA

    公开(公告)号：EP2061878A2

    公开(公告)日：2009-05-27

    申请号：EP07837971.6

    申请日：2007-09-07

    申请人： Ambrx, Inc.

    发明人： TIAN, Feng ,  NORMAN, Thea ,  CHU, Stephanie

    IPC分类号： C12N5/10 ,  C07H21/04 ,  C07H21/02

    CPC分类号： C12P21/02 ,  C12N9/93 ,  C12N15/11

    摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided. The present invention provides vertebrate cells with translation components, e.g., pairs of orthogonal aminoacyl-tRNA synthetases (O-RSs) and orthogonal tRNA's (O-tRNA's) and individual components thereof, that are used in vertebrate protein biosynthetic machinery to incorporate an unnatural amino acid in a growing polypeptide chain, in a vertebrate cell.

    摘要翻译： 本发明提供了用于产生翻译组分的组合物和方法，所述翻译组分增加了脊椎动物细胞中遗传编码的氨基酸的数量。 这些成分包括正交tRNA，正交氨酰-tRNA合成酶，正交tRNA /合成酶和非天然氨基酸。 还提供了在脊椎动物细胞中产生具有非天然氨基酸的蛋白质和方法。 本发明提供了具有翻译组分的脊椎动物细胞，例如用于脊椎动物蛋白质生物合成机器中的正交氨酰基-tRNA合成酶（O-RS）和正交tRNA（O-tRNA's）及其单个组分的成对以掺入非天然氨基 在生长的多肽链中，在脊椎动物细胞中。

    SUPPRESSOR TRNA TRANSCRIPTION IN VERTEBRATE CELLS
    10.
    发明公开
    SUPPRESSOR TRNA TRANSCRIPTION IN VERTEBRATE CELLS 有权
    抑制剂TRNA在脊椎细胞中的转录

    公开(公告)号：EP2064333A2

    公开(公告)日：2009-06-03

    申请号：EP07837972.4

    申请日：2007-09-07

    申请人： Ambrx, Inc.

    发明人： TIAN, Feng ,  NORMAN, Thea ,  CHU, Stephanie

    IPC分类号： C12P21/06 ,  C12N1/21

    CPC分类号： C12N15/85 ,  C12N9/93 ,  C12N15/11 ,  C12P21/02

    摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided.

    摘要翻译： 本发明提供了用于产生翻译组分的组合物和方法，所述翻译组分增加了脊椎动物细胞中遗传编码的氨基酸的数量。 这些成分包括正交tRNA，正交氨酰-tRNA合成酶，正交tRNA /合成酶和非天然氨基酸。 还提供了在脊椎动物细胞中产生具有非天然氨基酸的蛋白质和方法。