公开(公告)号：EP2055267B1

公开(公告)日：2013-04-17

申请号：EP09150116.3

申请日：2002-04-30

申请人： Amedica Corporation

发明人： Brodke, Darrel, S. ,  Khandkar, Ashok, C. ,  Rao, Mahendra, S. ,  Lakshminarayanan, Ramaswamy

IPC分类号： A61F2/28

CPC分类号： A61L27/3804 ,  A61F2/30767 ,  A61F2/442 ,  A61F2/446 ,  A61F2/447 ,  A61F2/4611 ,  A61F2002/2835 ,  A61F2002/30011 ,  A61F2002/30016 ,  A61F2002/30064 ,  A61F2002/30153 ,  A61F2002/30158 ,  A61F2002/30166 ,  A61F2002/30179 ,  A61F2002/30224 ,  A61F2002/30235 ,  A61F2002/30261 ,  A61F2002/30266 ,  A61F2002/30271 ,  A61F2002/3028 ,  A61F2002/30329 ,  A61F2002/30616 ,  A61F2002/30677 ,  A61F2002/30733 ,  A61F2002/30774 ,  A61F2002/30777 ,  A61F2002/30789 ,  A61F2002/3082 ,  A61F2002/30822 ,  A61F2002/30827 ,  A61F2002/3085 ,  A61F2002/30881 ,  A61F2002/30891 ,  A61F2002/30892 ,  A61F2002/30896 ,  A61F2002/3092 ,  A61F2002/30968 ,  A61F2002/4475 ,  A61F2002/4623 ,  A61F2002/4627 ,  A61F2002/4629 ,  A61F2002/4648 ,  A61F2220/0025 ,  A61F2230/0019 ,  A61F2230/0026 ,  A61F2230/0028 ,  A61F2230/0058 ,  A61F2230/0063 ,  A61F2230/0069 ,  A61F2230/0082 ,  A61F2250/0019 ,  A61F2250/0023 ,  A61F2310/00203 ,  A61F2310/00239 ,  A61F2310/00796 ,  A61F2310/00928 ,  A61F2310/0097 ,  A61F2310/00976 ,  A61L27/10 ,  A61L27/30 ,  A61L27/32 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3847 ,  A61L27/56 ,  A61L2430/02 ,  A61L2430/38

公开(公告)号：EP2055267A3

公开(公告)日：2009-08-12

申请号：EP09150116.3

申请日：2002-04-30

申请人： Amedica Corporation

发明人： Brodke, Darrel, S. ,  Khandkar, Ashok, C. ,  Rao, Mahendra, S. ,  Lakshminarayanan, Ramaswamy

IPC分类号： A61F2/28

CPC分类号： A61L27/3804 ,  A61F2/30767 ,  A61F2/442 ,  A61F2/446 ,  A61F2/447 ,  A61F2/4611 ,  A61F2002/2835 ,  A61F2002/30011 ,  A61F2002/30016 ,  A61F2002/30064 ,  A61F2002/30153 ,  A61F2002/30158 ,  A61F2002/30166 ,  A61F2002/30179 ,  A61F2002/30224 ,  A61F2002/30235 ,  A61F2002/30261 ,  A61F2002/30266 ,  A61F2002/30271 ,  A61F2002/3028 ,  A61F2002/30329 ,  A61F2002/30616 ,  A61F2002/30677 ,  A61F2002/30733 ,  A61F2002/30774 ,  A61F2002/30777 ,  A61F2002/30789 ,  A61F2002/3082 ,  A61F2002/30822 ,  A61F2002/30827 ,  A61F2002/3085 ,  A61F2002/30881 ,  A61F2002/30891 ,  A61F2002/30892 ,  A61F2002/30896 ,  A61F2002/3092 ,  A61F2002/30968 ,  A61F2002/4475 ,  A61F2002/4623 ,  A61F2002/4627 ,  A61F2002/4629 ,  A61F2002/4648 ,  A61F2220/0025 ,  A61F2230/0019 ,  A61F2230/0026 ,  A61F2230/0028 ,  A61F2230/0058 ,  A61F2230/0063 ,  A61F2230/0069 ,  A61F2230/0082 ,  A61F2250/0019 ,  A61F2250/0023 ,  A61F2310/00203 ,  A61F2310/00239 ,  A61F2310/00796 ,  A61F2310/00928 ,  A61F2310/0097 ,  A61F2310/00976 ,  A61L27/10 ,  A61L27/30 ,  A61L27/32 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3847 ,  A61L27/56 ,  A61L2430/02 ,  A61L2430/38

摘要： An improved ceramic bone graft is provided for human implantation, particularly such as a spinal fusion cage (10) for implantation into the intervertebral space between two adjacent vertebrae. The improved spinal fusion cage (10) includes a substrate block of high strength ceramic having a selected size and shape to fit the anatomical space, and a controlled porosity analogous to natural bone. The substrate block is coated with a bio-active surface coating material such as hydroxyapatite or a calcium phosphate to promote bone ingrowth and fusion. Upon implantation, the fusion cage (10) provides a spacer element having a desired combination of mechanical strength together with osteoconductivity and osteoinductivity to promote bone ingrowth and fusion, as well as radiolucency for facilitated post-operative monitoring. The fusion cage (10) may additionally carry one or more natural or synthetic therapeutic agents for further promoting bone ingrowth and fusion.