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    ANTI-ACTIVIN A ANTIBODIES AND USES THEREOF
    1.
    发明公开
    ANTI-ACTIVIN A ANTIBODIES AND USES THEREOF 审中-公开
    安东尼奥GEGEN ACTIVIN A UND VERWENDUNGEN DAVON

    公开(公告)号：EP3133084A1

    公开(公告)日：2017-02-22

    申请号：EP16178026.7

    申请日：2007-09-07

    申请人： Amgen Inc.

    发明人： HAN, Hq ,  CHEN, Qing ,  KWAK, Keith Soo-Nyung ,  ZHOU, Xiaolan

    IPC分类号： C07K16/22 ,  A61K39/395 ,  C12N15/13 ,  A61P5/06 ,  A61P9/10 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00

    摘要： The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.

    摘要翻译： 本公开提供与抗激活素A结合蛋白（包括抗体）相关或衍生的组合物和方法。 在具体实施方案中，本公开提供了完全人，人源化和嵌合的抗激活素A抗体，其结合人激活素A，激活素A结合片段和此类抗体的衍生物，以及包含此类片段的激活素A-结合多肽。 其他实施方案提供编码此类抗体，抗体片段和衍生物和多肽的核酸，包含此类多核苷酸的细胞，制备此类抗体的方法，抗体片段和衍生物和多肽，以及使用此类抗体，抗体片段和衍生物和多肽的方法，包括方法 治疗或诊断具有激活素A相关疾病或包括与性腺癌，其他癌症，类风湿性关节炎和其他疾病相关的恶病质的病症的受试者。

    NOVEL ACTIVIN RECEPTOR AND USES THEREOF
    2.
    发明授权
    NOVEL ACTIVIN RECEPTOR AND USES THEREOF 有权
    新激活及其应用

    公开(公告)号：EP1943273B1

    公开(公告)日：2012-04-18

    申请号：EP06827481.0

    申请日：2006-11-01

    申请人： Amgen Inc.

    发明人： HAN, HQ ,  KWAK, Keith Soo-Nyung ,  ZHOU, Xiaolan

    IPC分类号： C07K14/71

    CPC分类号： C07K14/71 ,  C07K2319/30

    摘要： The present invention provides novel activin IIB5 receptor polypeptides capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the receptor polypeptides. Compositions and methods for treating muscle-wasting, metabolic and other disorders are also provided.

    ANTI-ACTIVIN A ANTIBODIES AND USES THEREOF
    3.
    发明公开
    ANTI-ACTIVIN A ANTIBODIES AND USES THEREOF 审中-公开

    公开(公告)号：EP3730517A1

    公开(公告)日：2020-10-28

    申请号：EP20175809.1

    申请日：2007-09-07

    申请人： Amgen, Inc

    发明人： HAN, Hq ,  CHEN, Qing ,  KWAK, Keith Soo-Nyung ,  ZHOU, Xiaolan

    IPC分类号： C07K16/22 ,  A61K39/395 ,  C12N15/13 ,  A61P5/06 ,  A61P9/10 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  A61P1/00 ,  A61P3/04 ,  A61P5/00 ,  A61P7/00 ,  A61P9/00 ,  A61P19/02 ,  A61P29/00

    摘要： The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.

    ANTI-ACTIVIN A ANTIBODIES AND USES THEREOF
    6.
    发明公开
    ANTI-ACTIVIN A ANTIBODIES AND USES THEREOF 审中-公开

    公开(公告)号：EP3495388A1

    公开(公告)日：2019-06-12

    申请号：EP18203136.9

    申请日：2007-09-07

    申请人： Amgen Inc.

    发明人： HAN, Hq ,  CHEN, Qing ,  KWAK, Keith Soo-Nyung ,  ZHOU, Xiaolan

    IPC分类号： C07K16/22 ,  A61K39/395 ,  C12N15/13 ,  A61P5/06 ,  A61P9/10 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00

    摘要： The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.

    NOVEL ACTIVIN RECEPTOR AND USES THEREOF
    8.
    发明公开
    NOVEL ACTIVIN RECEPTOR AND USES THEREOF 有权
    新激活及其应用

    公开(公告)号：EP1943273A1

    公开(公告)日：2008-07-16

    申请号：EP06827481.0

    申请日：2006-11-01

    申请人： Amgen Inc.

    发明人： HAN, HQ ,  KWAK, Keith Soo-Nyung ,  ZHOU, Xiaolan

    IPC分类号： C07K14/435

    CPC分类号： C07K14/71 ,  C07K2319/30

    摘要： The present invention provides novel activin IIB5 receptor polypeptides capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the receptor polypeptides. Compositions and methods for treating muscle-wasting, metabolic and other disorders are also provided.