公开(公告)号：EP2311808A1

公开(公告)日：2011-04-20

申请号：EP10176822.4

申请日：2002-01-11

申请人： Amgen Inc.

发明人： Chen, Guoqung ,  Adams, Jeffrey ,  Bernis, Jean ,  Booker, Shon ,  Cai, Guolin ,  Croghan, Michael ,  Dipietro, Lucian ,  Dominguez, Celia ,  Elbaum, Daniel ,  Germain, Julie ,  Geuns-Meyer, Stephanie ,  Handley, Michael ,  Huang, Qi ,  Kim, L. Joseph ,  Kim, Tae-Seong ,  Kiselyov, Alexander ,  Ouyang, Xiaohu ,  Patel, F. Vinod ,  Smith, M. Leon ,  Stec, Markian ,  Tasker, Andrew ,  Xi, Ning ,  Xu, Shimin ,  Yuan, Chenguan Chester

IPC分类号： C07D213/82 ,  C07D401/12

CPC分类号： C07D213/82 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/00 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1619184A3

公开(公告)日：2006-02-01

申请号：EP05015480.6

申请日：2001-08-15

申请人： Amgen, Inc.

发明人： Santora, Vincent ,  Ghose, Arup ,  Kim, Tae-Seong ,  Askew, Benny ,  Hague, Andrew ,  Laber, Ellen ,  Li, Aiwen ,  Lian, Brian ,  Liu, Gang ,  Norman, Mark Henry ,  Smith, Leon ,  Tasker, Andrew ,  Tegley, Christopher ,  Yang, Kevin

IPC分类号： C07D213/75

CPC分类号： C07D213/75 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D491/10

摘要： Selected novel urea compounds are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP2578583A1

公开(公告)日：2013-04-10

申请号：EP12000581.4

申请日：2007-07-13

申请人： Amgen Inc.

发明人： Albrecht, Brian ,  Bauer, David ,  Bellon, Steven ,  Bode, Christiane ,  Booker, Shon ,  Boezio, Alessandro ,  Choquette, Deborah ,  D'Amico, Derin ,  Harmange, Jean-Christophe ,  Hungate, Randall W. ,  Hirai, Satoko ,  Kim, Tae-Seong ,  Lewis, Richard T. ,  Liu, Longbin ,  Lohman, Julia ,  Norman, Mark ,  Potashman, Michele ,  Siegmund, Aaron ,  Springer, Stephanie ,  Stec, Markian ,  Xi, Ning ,  Yang, Kevin

IPC分类号： C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  A61K31/5025 ,  A61K31/52 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D471/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：EP3093289A1

公开(公告)日：2016-11-16

申请号：EP16175883.4

申请日：2007-07-13

申请人： Amgen, Inc

发明人： Albrecht, Brian ,  Bauer, David ,  Bellon, Steven ,  Bode, Christiane M. ,  Booker, Shon ,  Boezio, Alessandro ,  Choquette, Deborah ,  D'Amico, Derin C. ,  Harmange, Jean Christophe ,  Hirai, Satoko ,  Hungate, Randall W. ,  Kim, Tae-Seong ,  Lewis, Richard T. ,  Longbin, Liu ,  Lohman, Julia ,  Norman, Mark H. ,  Potashman, Michele ,  Siegmund, Aaron C. ,  Springer, Stephanie ,  Xi, Ning ,  Yang, Kevin ,  Stec, Markian

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D471/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：EP2311829A1

公开(公告)日：2011-04-20

申请号：EP10176821.6

申请日：2002-01-11

申请人： Amgen Inc.

发明人： Chen, Guoqung ,  Adams, Jeffrey ,  Bemis, Jean ,  Booker, Shon ,  Cai, Guolin ,  Croghan, Michael ,  Dipietro, Lucian ,  Dominguez, Celia ,  Elbaum, Daniel ,  Germain, Julie ,  Geuns-Meyer, Stephanie ,  Handley, Michael ,  Huang, Qi ,  Kim, L. Joseph ,  Kim, Tae-Seong ,  Kiselyov, Alexander ,  Ouyang, Xiaohu ,  Patel, Vinod, F. ,  Smith, Leon, M. ,  Markian, Stec ,  Tasker, Andrew ,  Xi, Ning ,  Xu, Shimin ,  Yuan, Chester, Chenguang

IPC分类号： C07D409/12 ,  C07D409/14 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D409/04 ,  C07D413/14 ,  C07D417/14 ,  C07D405/14 ,  C07D405/12

CPC分类号： C07D213/82 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/00 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 选定的杂环化合物对于预防和治疗疾病如血管生成介导的疾病是有效的。 本发明包括新型化合物，类似物，前药和药学上可接受的衍生物，用于预防和治疗涉及癌症等的疾病和其他疾病或病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及用于这些方法的中间体。

公开(公告)号：EP1798230A1

公开(公告)日：2007-06-20

申请号：EP07003413.7

申请日：2002-01-11

申请人： Amgen Inc.

发明人： Chen, Guoqing ,  Adams, Jeffrey ,  Bemis, Jean ,  Booker, Shon ,  Cai, Guolin ,  Croghan, Michael ,  Dipietro, Lucian ,  Dominguez, Celia ,  Elbaum, Daniel ,  Germain, Julie ,  Geuns-Meyer, Stephanie ,  Handley, Michael ,  Huang, Qi ,  Kim, L. Joseph ,  Kim, Tae-Seong ,  Kiselyov, Alexander ,  Ouyang, Xiaohu ,  Patel, Vinod, F. ,  Smith, Leon, M. ,  Stec, Markian ,  Tasker, Andrew ,  Xi, Ning ,  Xu, Shimin ,  Yuan, Chester, Chenguang

IPC分类号： C07D409/12 ,  C07D409/14 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D409/04 ,  C07D413/14 ,  C07D417/14 ,  C07D405/14 ,  C07D405/12

CPC分类号： C07D213/82 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/00 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1619184A2

公开(公告)日：2006-01-25

申请号：EP05015480.6

申请日：2001-08-15

申请人： Amgen, Inc.

发明人： Santora, Vincent ,  Ghose, Arup ,  Kim, Tae-Seong ,  Askew, Benny ,  Hague, Andrew ,  Laber, Ellen ,  Li, Aiwen ,  Lian, Brian ,  Liu, Gang ,  Norman, Mark Henry ,  Smith, Leon ,  Tasker, Andrew ,  Tegley, Christopher ,  Yang, Kevin

IPC分类号： C07D213/75

CPC分类号： C07D213/75 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D491/10

摘要： Selected novel urea compounds are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 选择的新型脲化合物对于预防和治疗疾病如细胞增殖或凋亡介导的疾病是有效的。 本发明包括新型化合物，类似物，前药和药学上可接受的盐，用于预防和治疗涉及中风，癌症等疾病和其他疾病或病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及用于这些方法的中间体。