利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

7 条记录 (耗时 0.038 秒)

    Vanilloid receptor ligands and their use in treatments
    4.
    发明公开
    Vanilloid receptor ligands and their use in treatments 审中-公开
    Vanillaid Rezeptor-Liganden und ihre Verwendung in medizinischen Behandlungen

    公开(公告)号：EP1818333A1

    公开(公告)日：2007-08-15

    申请号：EP07009856.1

    申请日：2004-02-09

    申请人： Amgen Inc.

    发明人： Doherty, Elizabeth M. ,  Fotsch, Christopher H. ,  Han, Nianhe ,  Hungate, Randall W. ,  Liu, Qingyian ,  Norman, Mark H. ,  Xi, Ning ,  Xu, Shimin

    IPC分类号： C07D417/04 ,  C07D417/12 ,  C07D403/04 ,  C07D277/20 ,  C07D233/66 ,  C07D263/34 ,  A61P29/00 ,  A61K41/00

    CPC分类号： C07D233/90 ,  C07D263/34 ,  C07D277/56 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

    摘要： Compounds having the general structure

    and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

    摘要翻译： 具有一般结构和含有它们的组合物的化合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性 疾病，骨关节炎，炎症性肠病，炎症性眼病，炎性或不稳定性膀胱病，牛皮癣，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病痛， 咳嗽痛，交感神经保持疼痛，交感综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道内脏运动紊乱，泌尿生殖道，胃肠道或血管区，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风，一般胃肠道疾病， G 腹部溃疡，十二指肠溃疡，腹泻，坏死因子诱发的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。