公开(公告)号：EP3558955A2

公开(公告)日：2019-10-30

申请号：EP17832646.8

申请日：2017-12-21

申请人： Amgen Inc.

发明人： LANMAN, Brian Alan ,  CEE, Victor J. ,  PICKRELL, Alexander J. ,  REED, Anthony B. ,  YANG, Kevin C. ,  KOPECKY, David John ,  WANG, Hui-Ling ,  LOPEZ, Patricia ,  ASHTON, Kate ,  BOOKER, Shon ,  TEGLEY, Christopher M.

IPC分类号： C07D275/04 ,  C07D417/04 ,  C07D471/08 ,  C07D513/04 ,  C07D487/10 ,  C07D487/04 ,  C07D239/80 ,  C07D471/04 ,  C07D401/04 ,  C07D403/04 ,  A61K31/428 ,  A61K31/429 ,  A61K31/437 ,  A61K31/517 ,  A61K31/519 ,  A61K31/498 ,  A61K31/4985 ,  A61P35/00

公开(公告)号：EP2702063A1

公开(公告)日：2014-03-05

申请号：EP12717554.5

申请日：2012-04-19

申请人： Amgen Inc.

发明人： D'AMICO, Derin C. ,  HERBERICH, Bradley J. ,  JACKSON, Claire L.M. ,  PETTUS, Liping H. ,  TASKER, Andrew ,  WANG, Hui-Ling ,  WU, Bin ,  WURZ, Ryan

IPC分类号： C07D487/04 ,  A61K31/495 ,  A61P35/00

CPC分类号： C07D487/04

摘要： The invention relates to bicyclic compounds of formulas I and I', and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.

公开(公告)号：EP1720868B1

公开(公告)日：2009-11-04

申请号：EP05722962.7

申请日：2005-02-11

申请人： AMGEN INC.

发明人： WANG, Hui-Ling ,  BALAN, Chenera ,  DOHERTY, Elizabeth, M. ,  FALSEY, James, Richard ,  GORE, Vijay, Keshav ,  KATON, Jodie ,  NORMAN, Mark, H.

IPC分类号： C07D417/12 ,  C07D417/14 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/04 ,  A61K31/506 ,  A61P29/00

CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

摘要： Pyrimidine ethers and compositions containing them, fo use as vanilloid receptor ligands for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders. Wherein R1 - R4 and X are as defined in the claims.

公开(公告)号：EP1507776B1

公开(公告)日：2007-02-28

申请号：EP03741829.0

申请日：2003-05-29

申请人： AMGEN INC.

发明人： HUANG, Qi ,  KALLER, Matthew ,  NGUYEN, Thomas ,  NORMAN, Mark, H. ,  RZASA, Robert ,  WANG, Hui-Ling ,  ZHONG, Wenge

IPC分类号： C07D417/14 ,  C07D403/04 ,  C07D491/04 ,  C07D417/04 ,  C07D409/14 ,  C07D513/04 ,  C07D471/04 ,  A61K31/505 ,  A61P25/00 ,  A61P35/00

CPC分类号： C07D403/04 ,  C07D409/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D491/04 ,  C07D513/04

摘要： Compounds of formula (I) are effective for treatment of cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP4268898A2

公开(公告)日：2023-11-01

申请号：EP23182678.5

申请日：2019-06-10

申请人： Amgen Inc.

发明人： CHEN, Jian ,  TAMAYO, Nuria A. ,  LIU, Longbin ,  WANG, Hui-Ling ,  LANMAN, Brian Alan ,  WURZ, Ryan Paul ,  SHIN, Youngsook ,  CEE, Victor J.

IPC分类号： A61P35/00

摘要： Provided herein are KRAS G12C inhibitors, such as

composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

公开(公告)号：EP2649065A1

公开(公告)日：2013-10-16

申请号：EP11802248.2

申请日：2011-12-07

申请人： Amgen Inc.

发明人： WANG, Hui-Ling ,  BISWAS, Kaustav ,  CEE, Victor J. ,  CHAVEZ JR., Frank ,  HERBERICH, Bradley ,  JACKSON, Claire L.M. ,  LEE, Matthew ,  NIXEY, Thomas ,  PETTUS, Liping H. ,  REED, Anthony B. ,  RZASA, Robert M. ,  RUMFELT, Shannon ,  TASKER, Andrew ,  WU, Bin ,  WURZ, Ryan ,  LANMAN, Brian, A.

IPC分类号： C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D491/107 ,  A61K31/497 ,  A61K31/437 ,  A61K31/506 ,  A61K31/444 ,  A61K31/4709

CPC分类号： C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： The invention relates to bicyclic compounds of formula (1'), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.

公开(公告)号：EP1745034A1

公开(公告)日：2007-01-24

申请号：EP05722957.7

申请日：2005-02-11

申请人： AMGEN INC.

发明人： BALAN, Chenera ,  CHEN, Ning ,  DOHERTY, Elizabeth M. ,  GORE, Vijay Keshav ,  NORMAN, Mark H. ,  WANG, Hui-Ling

IPC分类号： C07D401/12 ,  C07D417/12 ,  C07D413/12 ,  C07D403/12 ,  C07D417/14 ,  C07D401/14 ,  C07D403/14 ,  A61K31/44 ,  A61K31/444

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

摘要： Compounds having the general structure (I) and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndroms, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

公开(公告)号：EP4403175A2

公开(公告)日：2024-07-24

申请号：EP24151885.1

申请日：2018-09-07

申请人： Amgen Inc.

发明人： LANMAN, Brian Alan ,  BOOKER, Shon ,  GOODMAN, Clifford ,  REED, Anthony B. ,  LOW, Jonathan D. ,  WANG, Hui-Ling ,  CHEN, Ning ,  MINATTI, Ana Elena ,  WURZ, Ryan ,  CEE, Victor J.

IPC分类号： A61K31/519

CPC分类号： A61P35/00 ,  A61K31/519 ,  A61K31/7068 ,  A61K38/07 ,  C07D471/04

摘要： Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

公开(公告)号：EP4251624A1

公开(公告)日：2023-10-04

申请号：EP21827727.5

申请日：2021-11-22

申请人： Amgen, Inc

发明人： AMEGADZIE, Albert ,  BEYLKIN, Diane Jennifer ,  BOOKER, Shon ,  BOURBEAU, Matthew Paul ,  BUTLER, John R. ,  GLAD, Sanne Omholt Schroder ,  KOHN, Todd J. ,  LANMAN, Brian Alan ,  LI, Kexue ,  LIU, Qingyian ,  LOPEZ, Patricia ,  MANONI, Francesco ,  NAVARATNE, Primali Vasundera ,  PETTUS, Liping H. ,  RAHIMOFF, Rene ,  TAMAYO, Nuria A. ,  VESTERGAARD, Mikkel ,  WANG, Hui-Ling ,  WEIRES, Nicholas Anthony

IPC分类号： C07D471/04 ,  A61K31/4355 ,  A61K31/437 ,  A61K31/501 ,  A61P35/00 ,  C07D491/048 ,  C07D491/147 ,  C07D471/14 ,  C07D498/04 ,  C07D401/14 ,  C07D401/12 ,  C07D495/04

公开(公告)号：EP4141005A1

公开(公告)日：2023-03-01

申请号：EP22176014.3

申请日：2018-09-07

申请人： Amgen Inc.

发明人： LANMAN, Brian Alan ,  BOOKER, Shon ,  GOODMAN, Clifford ,  REED, Anthony B. ,  LOW, Jonathan D. ,  WANG, Hui-Ling ,  CHEN, Ning ,  MINATTI, Ana Elena ,  WURZ, Ryan ,  CEE, Victor J.

IPC分类号： C07D471/04 ,  A61P35/00 ,  A61K31/519

摘要： Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.