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公开(公告)号：EP2358656A2
公开(公告)日：2011-08-24
申请号：EP09741123.5
申请日：2009-10-13
申请人： Amgen, Inc
发明人： BROWN, Sean P. , DRANSFIELD, Paul , DU, Xiaohui , FU, Zice , HOUZE, Jonathan , JIAO, XianYun , LAI, SuJen , LI, An-Rong , LIU, Jiwen , MA, Zhihua , MEDINA, Julio C. , PATTAROPONG, Vatee , SHEN, Wang , VIMOLRATANA, Marc , WANG, Yingcai , WANG, Zhongyu , YU, Ming , ZHU, Liusheng
IPC分类号： C07C62/34 , C07D249/00 , C07D277/00 , C07D311/00 , C07D231/00 , C07D271/00 , C07D221/00
CPC分类号： C07C62/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/643 , C07D217/24 , C07D253/065 , C07D277/22 , C07D311/04 , C07D401/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I'A or I'B, where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
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2.发明授权PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER 有权PIPERIDINONDERIVATE ALS MDM2-HEMMER ZUR KREBSBEHANDLUNG
公开(公告)号：EP2576510B1
公开(公告)日：2015-04-29
申请号：EP11726581.9
申请日：2011-06-03
申请人： Amgen Inc.
发明人： BARTBERGER, Michael David , GONZALEZ BUENROSTRO, Ana , BECK, Hilary Plake , CHEN, Xiaoqi , CONNORS, Richard Victor , DEIGNAN, Jeffrey , DUQUETTE, Jason , EKSTEROWICZ, John , FISHER, Benjamin , FOX, Brian Matthew , FU, Jiasheng , FU, Zice , GONZALEZ LOPEZ DE TURISO, Felix , GRIBBLE, JR., Michael William , GUSTIN, Darin James , HEATH, Julie Anne , HUANG, Xin , JIAO, Xianyun , JOHNSON, Michael , KAYSER, Frank , KOPECKY, David John , LAI, Sujen , LI, Yihong , LI, Zhihong , LIU, Jiwen , LOW, Jonathan Dante , LUCAS, Brian Stuart , MA, Zhihua , MCGEE, Lawrence , MCINTOSH, Joel , MCMINN, Dustin , MEDINA, Julio Cesar , MIHALIC, Jeffrey Thomas , OLSON, Steven Howard , REW, Yosup , ROVETO, Philip Marley , SUN, Daqing , WANG, Xiaodong , WANG, Yingcai , YAN, Xuelei , YU, Ming , ZHU, Jiang
IPC分类号： C07D211/40 , C07D401/04 , C07D401/06 , C07D407/04 , C07D407/06 , C07D409/04 , C07D413/06 , C07D417/06 , C07D471/20 , C07D279/02 , C07D401/12 , C07D498/08 , C07D498/20 , A61K31/4412 , A61P35/00
CPC分类号： C07D211/76 , C07D221/20 , C07D279/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D407/04 , C07D407/06 , C07D409/04 , C07D409/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/10 , C07D491/08 , C07D491/153 , C07D498/08 , C07D498/14 , C07D498/20
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3.发明公开PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER 有权PIPERIDINONDERIVATE AS MDM2抑制剂用于癌症治疗
公开(公告)号：EP2576510A1
公开(公告)日：2013-04-10
申请号：EP11726581.9
申请日：2011-06-03
申请人： Amgen Inc.
发明人： BARTBERGER, Michael David , GONZALEZ BUENROSTRO, Ana , BECK, Hilary Plake , CHEN, Xiaoqi , CONNORS, Richard Victor , DEIGNAN, Jeffrey , DUQUETTE, Jason , EKSTEROWICZ, John , FISHER, Benjamin , FOX, Brian Matthew , FU, Jiasheng , FU, Zice , GONZALEZ LOPEZ DE TURISO, Felix , GRIBBLE, JR., Michael William , GUSTIN, Darin James , HEATH, Julie Anne , HUANG, Xin , JIAO, Xianyun , JOHNSON, Michael , KAYSER, Frank , KOPECKY, David John , LAI, Sujen , LI, Yihong , LI, Zhihong , LIU, Jiwen , LOW, Jonathan Dante , LUCAS, Brian Stuart , MA, Zhihua , MCGEE, Lawrence , MCINTOSH, Joel , MCMINN, Dustin , MEDINA, Julio Cesar , MIHALIC, Jeffrey Thomas , OLSON, Steven Howard , REW, Yosup , ROVETO, Philip Marley , SUN, Daqing , WANG, Xiaodong , WANG, Yingcai , YAN, Xuelei , YU, Ming , ZHU, Jiang
IPC分类号： C07D211/40 , C07D401/04 , C07D401/06 , C07D407/04 , C07D407/06 , C07D409/04 , C07D413/06 , C07D417/06 , C07D471/20 , C07D279/02 , C07D401/12 , C07D498/08 , C07D498/20 , A61K31/4412 , A61P35/00
CPC分类号： C07D211/76 , C07D221/20 , C07D279/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D407/04 , C07D407/06 , C07D409/04 , C07D409/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/10 , C07D491/08 , C07D491/153 , C07D498/08 , C07D498/14 , C07D498/20
摘要： The present invention provides MDM2 inhibitor compounds of Formula (I), wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
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4.发明公开
公开(公告)号：EP2260017A1
公开(公告)日：2010-12-15
申请号：EP09717135.9
申请日：2009-03-04
申请人： Amgen, Inc
发明人： BROWN, Sean, P. , DRANSFIELD, Paul, J. , HOUZE, Jonathan , KOHN, Todd, J. , LIU, Jiwen , MEDINA, Julio , PATTAROPONG, Vatee , SHEN, Wang , VIMOLRATANA, Marc , WANG, Yingcai , YU, Ming , ZHU, Liusheng
IPC分类号： C07C59/72 , C07D213/64 , A61K31/192 , A61P3/10 , A61P9/00 , A61K31/435
CPC分类号： C07C59/72
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I or the general formula III: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
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公开(公告)号：EP2358656B1
公开(公告)日：2014-01-01
申请号：EP09741123.5
申请日：2009-10-13
申请人： Amgen, Inc
发明人： BROWN, Sean P. , DRANSFIELD, Paul , DU, Xiaohui , FU, Zice , HOUZE, Jonathan , JIAO, XianYun , LAI, SuJen , LI, An-Rong , LIU, Jiwen , MA, Zhihua , MEDINA, Julio C. , PATTAROPONG, Vatee , SHEN, Wang , VIMOLRATANA, Marc , WANG, Yingcai , WANG, Zhongyu , YU, Ming , ZHU, Liusheng
IPC分类号： C07C62/34 , C07D249/00 , C07D277/00 , C07D311/00 , C07D231/00 , C07D271/00 , C07D221/00
CPC分类号： C07C62/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/643 , C07D217/24 , C07D253/065 , C07D277/22 , C07D311/04 , C07D401/12
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公开(公告)号：EP2205548A1
公开(公告)日：2010-07-14
申请号：EP08837085.3
申请日：2008-10-03
申请人： Amgen, Inc
发明人： KIM, Yong-Jae , BROWN, Sean, P. , CAO, Qiong , DRANSFIELD, Paul, J. , DU, Xiaohui , HOUZE, Jonathan , JIAO, Xian Yun , KOHN, Todd, J. , LAI, Sujen , LI, An-Rong , LIN, Daniel , LUO, Jian , MEDINA, Julio, C. , REAGAN, Jeffrey, D. , PATTAROPONG, Vatee , SCHWARZ, Margrit , SHEN, Wang , SU, Yongli , SWAMINATH, Gayathri , VIMOLRATANA, Marc , WANG, Xiang , XIONG, Yumei , YANG, Li , YU, Ming , ZHANG, Jie , ZHU, Liusheng , FU, Zice , LIU, Jiwen , WANG, Yingcai
IPC分类号： C07C59/68 , C07C217/54 , C07C323/19 , C07D213/64 , A61K31/192 , A61K31/4415 , A61P3/10
CPC分类号： C07C323/62 , C07C59/68 , C07C59/72 , C07C217/54 , C07C217/62 , C07C317/22 , C07C323/19 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D213/64 , C07D309/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病如II型糖尿病中的使用方法。
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公开(公告)号：EP2079728A1
公开(公告)日：2009-07-22
申请号：EP07839443.4
申请日：2007-10-09
申请人： Amgen Inc.
发明人： OGAWA, Yasuyuki , OKUYAMA, Ryo , SHIBUYA, Satoshi , TODA, Narihiro , CAO, Zhaodan , FU, Zice , HAO, Xiaolin , KIM, Yong-jae , LI, Leping , LIVELY, Sarah E. , LIZARZABURU, Mike , TIAN, Hui , YU, Ming
IPC分类号： C07D401/14 , C07D403/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07D487/04 , A61K31/506 , A61P3/10
CPC分类号： C07D409/14 , C07D401/14 , C07D403/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Compounds having formula I:where A1, A2, L, V, W, R1, R2, R3, R4 and R5 are as described herein, compositions thereof, and their use for the treatment or prevention of type 2 diabetes and type 2 diabetes-related conditions are provided herein.
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公开(公告)号：EP3186259A1
公开(公告)日：2017-07-05
申请号：EP15772048.3
申请日：2015-08-28
申请人： Amgen Inc.
发明人： BROWN, Sean P. , LI, Yunxiao , LIZARZABURU, Mike Elias , LUCAS, Brian S. , PARAS, Nick A. , TAYGERLY, Joshua , VIMOLRATANA, Marc , WANG, Xianghong , YU, Ming , ZANCANELLA, Manuel , ZHU, Liusheng , GONZALEZ BUENROSTRO, Ana , LI, Zhihong
IPC分类号： C07D513/08 , A61K31/554 , A61P35/00
CPC分类号： C07D513/10 , C07D513/08
摘要： Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.
摘要翻译： 及其药学上可接受的盐和含有该化合物的药物组合物。 本文提供的化合物和组合物可以用于例如治疗疾病或病症如癌症。
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公开(公告)号：EP2079728B1
公开(公告)日：2013-09-25
申请号：EP07839443.4
申请日：2007-10-09
申请人： Amgen Inc.
发明人： OGAWA, Yasuyuki , OKUYAMA, Ryo , SHIBUYA, Satoshi , TODA, Narihiro , CAO, Zhaodan , FU, Zice , HAO, Xiaolin , KIM, Yong-jae , LI, Leping , LIVELY, Sarah E. , LIZARZABURU, Mike , TIAN, Hui , YU, Ming
IPC分类号： C07D401/14 , C07D403/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07D487/04 , A61K31/506 , A61P3/10
CPC分类号： C07D409/14 , C07D401/14 , C07D403/04 , C07D417/14 , C07D471/04 , C07D487/04
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