公开(公告)号：EP2358656B1

公开(公告)日：2014-01-01

申请号：EP09741123.5

申请日：2009-10-13

申请人： Amgen, Inc

发明人： BROWN, Sean P. ,  DRANSFIELD, Paul ,  DU, Xiaohui ,  FU, Zice ,  HOUZE, Jonathan ,  JIAO, XianYun ,  LAI, SuJen ,  LI, An-Rong ,  LIU, Jiwen ,  MA, Zhihua ,  MEDINA, Julio C. ,  PATTAROPONG, Vatee ,  SHEN, Wang ,  VIMOLRATANA, Marc ,  WANG, Yingcai ,  WANG, Zhongyu ,  YU, Ming ,  ZHU, Liusheng

IPC分类号： C07C62/34 ,  C07D249/00 ,  C07D277/00 ,  C07D311/00 ,  C07D231/00 ,  C07D271/00 ,  C07D221/00

CPC分类号： C07C62/34 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/14 ,  C07D213/643 ,  C07D217/24 ,  C07D253/065 ,  C07D277/22 ,  C07D311/04 ,  C07D401/12

公开(公告)号：EP1893582B1

公开(公告)日：2011-12-14

申请号：EP06770714.1

申请日：2006-05-18

申请人： Amgen, Inc

发明人： HOUZE, Jonathan ,  LIU, Jiwen ,  MA, Zhihua ,  MEDINA, Julio C. ,  SCHMITT, Michael J. ,  SHARMA, Rajiv ,  SUN, Ying ,  WANG, Yingcai ,  ZHU, Liusheng

IPC分类号： C07D233/54 ,  C07D249/08 ,  C07D257/04 ,  C07D263/32 ,  C07D277/24 ,  C07D417/12 ,  A61K31/41 ,  A61K31/4164 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/427 ,  A61P3/10 ,  A61P3/04 ,  A61P3/06

CPC分类号： C07D277/24 ,  C07B2200/07 ,  C07C235/34 ,  C07D233/64 ,  C07D249/08 ,  C07D257/04 ,  C07D263/32 ,  C07D417/12

摘要： The present invention provides compounds useful, for example, for modulating insulin levels in a subject, having the general formula I: wherein Q is an optionally substituted phenyl; L is a bond or O; P is a benzene or an optionally substituted thiazole ring; and R1 has the values provided herein. The present invention also provides compositions, uses, and methods for use of the compounds, for instance, for treatment of type II diabetes.

公开(公告)号：EP2205548A1

公开(公告)日：2010-07-14

申请号：EP08837085.3

申请日：2008-10-03

申请人： Amgen, Inc

发明人： KIM, Yong-Jae ,  BROWN, Sean, P. ,  CAO, Qiong ,  DRANSFIELD, Paul, J. ,  DU, Xiaohui ,  HOUZE, Jonathan ,  JIAO, Xian Yun ,  KOHN, Todd, J. ,  LAI, Sujen ,  LI, An-Rong ,  LIN, Daniel ,  LUO, Jian ,  MEDINA, Julio, C. ,  REAGAN, Jeffrey, D. ,  PATTAROPONG, Vatee ,  SCHWARZ, Margrit ,  SHEN, Wang ,  SU, Yongli ,  SWAMINATH, Gayathri ,  VIMOLRATANA, Marc ,  WANG, Xiang ,  XIONG, Yumei ,  YANG, Li ,  YU, Ming ,  ZHANG, Jie ,  ZHU, Liusheng ,  FU, Zice ,  LIU, Jiwen ,  WANG, Yingcai

IPC分类号： C07C59/68 ,  C07C217/54 ,  C07C323/19 ,  C07D213/64 ,  A61K31/192 ,  A61K31/4415 ,  A61P3/10

CPC分类号： C07C323/62 ,  C07C59/68 ,  C07C59/72 ,  C07C217/54 ,  C07C217/62 ,  C07C317/22 ,  C07C323/19 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07C2602/42 ,  C07C2603/74 ,  C07D213/64 ,  C07D309/12

摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

摘要翻译： 本发明提供了可用于例如治疗受试者代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病如II型糖尿病中的使用方法。

公开(公告)号：EP2358656A2

公开(公告)日：2011-08-24

申请号：EP09741123.5

申请日：2009-10-13

申请人： Amgen, Inc

发明人： BROWN, Sean P. ,  DRANSFIELD, Paul ,  DU, Xiaohui ,  FU, Zice ,  HOUZE, Jonathan ,  JIAO, XianYun ,  LAI, SuJen ,  LI, An-Rong ,  LIU, Jiwen ,  MA, Zhihua ,  MEDINA, Julio C. ,  PATTAROPONG, Vatee ,  SHEN, Wang ,  VIMOLRATANA, Marc ,  WANG, Yingcai ,  WANG, Zhongyu ,  YU, Ming ,  ZHU, Liusheng

IPC分类号： C07C62/34 ,  C07D249/00 ,  C07D277/00 ,  C07D311/00 ,  C07D231/00 ,  C07D271/00 ,  C07D221/00

CPC分类号： C07C62/34 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/14 ,  C07D213/643 ,  C07D217/24 ,  C07D253/065 ,  C07D277/22 ,  C07D311/04 ,  C07D401/12

摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I'A or I'B, where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

公开(公告)号：EP1893582A2

公开(公告)日：2008-03-05

申请号：EP06770714.1

申请日：2006-05-18

申请人： Amgen, Inc

发明人： HOUZE, Jonathan ,  LIU, Jiwen ,  MA, Zhihua ,  MEDINA, Julio C. ,  SCHMITT, Michael J. ,  SHARMA, Rajiv ,  SUN, Ying ,  WANG, Yingcai ,  ZHU, Liusheng

IPC分类号： C07D233/54 ,  C07D249/08 ,  C07D257/04 ,  C07D263/32 ,  C07D277/24 ,  C07D417/12 ,  A61K31/41 ,  A61K31/4164 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/427 ,  A61P3/10 ,  A61P3/04 ,  A61P3/06

CPC分类号： C07D277/24 ,  C07B2200/07 ,  C07C235/34 ,  C07D233/64 ,  C07D249/08 ,  C07D257/04 ,  C07D263/32 ,  C07D417/12

摘要： The present invention provides compounds useful, for example, for modulating insulin levels in a subject, having the general formula I: wherein Q is an optionally substituted phenyl; L is a bond or O; P is a benzene or an optionally substituted thiazole ring; and R1 has the values provided herein. The present invention also provides compositions, uses, and methods for use of the compounds, for instance, for treatment of type II diabetes.

公开(公告)号：EP3186259A1

公开(公告)日：2017-07-05

申请号：EP15772048.3

申请日：2015-08-28

申请人： Amgen Inc.

发明人： BROWN, Sean P. ,  LI, Yunxiao ,  LIZARZABURU, Mike Elias ,  LUCAS, Brian S. ,  PARAS, Nick A. ,  TAYGERLY, Joshua ,  VIMOLRATANA, Marc ,  WANG, Xianghong ,  YU, Ming ,  ZANCANELLA, Manuel ,  ZHU, Liusheng ,  GONZALEZ BUENROSTRO, Ana ,  LI, Zhihong

IPC分类号： C07D513/08 ,  A61K31/554 ,  A61P35/00

CPC分类号： C07D513/10 ,  C07D513/08

摘要： Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

摘要翻译： 及其药学上可接受的盐和含有该化合物的药物组合物。 本文提供的化合物和组合物可以用于例如治疗疾病或病症如癌症。

公开(公告)号：EP2001844A2

公开(公告)日：2008-12-17

申请号：EP07752941.0

申请日：2007-03-12

申请人： Amgen, Inc

发明人： SHARMA, Rajiv ,  AKERMAN, Michelle ,  CARDOZO, Mario, G. ,  HOUZE, Jonathan, B. ,  LI, An-Rong ,  LIU, Jinqian ,  LIU, Jiwen ,  MA, Zhihua ,  MEDINA, Julio, C. ,  SCHMITT, Michael, J. ,  SUN, Ying ,  WANG, Yingcai ,  WANG, Zhongyu ,  ZHU, Liusheng

IPC分类号： C07D209/08 ,  C07D209/46 ,  C07D215/22 ,  C07D277/24 ,  C07D311/74 ,  C07D313/08 ,  C07D417/12 ,  C07D498/04 ,  C07C59/54 ,  C07C59/72 ,  A61K31/426 ,  A61P3/10

CPC分类号： C07C57/62 ,  C07C59/64 ,  C07C59/72 ,  C07D209/08 ,  C07D209/46 ,  C07D215/20 ,  C07D215/227 ,  C07D277/24 ,  C07D311/58 ,  C07D311/74 ,  C07D311/76 ,  C07D313/08 ,  C07D417/12 ,  C07D498/04

摘要： Compounds having the general formula I and/or the general formula II are useful, for example, for treating metabolic disorders in a subject formula (I) (II) where the variables are provided herein. Compositions and methods for using the compounds for preparing medicaments and for treating metabolic disorders such as, for instance, type II diabetes are disclosed.

公开(公告)号：EP1924546A1

公开(公告)日：2008-05-28

申请号：EP06814336.1

申请日：2006-09-08

申请人： Amgen, Inc

发明人： AKERMAN, Michelle ,  BROWN, Sean ,  HOUZE, Jonathan, B. ,  LIU, Jinqian ,  MA, Zhihua ,  MEDINA, Julio, C. ,  QIU, Wei ,  SCHMITT, Michael, J. ,  WANG, Yingcai ,  ZHU, Liusheng ,  LIU Jiwen ,  SHARMA, Rajiv

IPC分类号： C07C59/72

CPC分类号： C07D333/24 ,  C07C59/72 ,  C07D231/12 ,  C07D233/26 ,  C07D233/64 ,  C07D239/26 ,  C07D249/04 ,  C07D249/08 ,  C07D257/04 ,  C07D261/04 ,  C07D261/08 ,  C07D263/32 ,  C07D317/54 ,  C07D333/16

摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: (F) where the definitions of the variables Q, L1, , L2, M, X, L3, and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

公开(公告)号：EP1737809B1

公开(公告)日：2013-09-18

申请号：EP05723623.4

申请日：2005-02-24

申请人： Amgen, Inc

发明人： AKERMAN, Michelle ,  HOUZE, Jonathan ,  LIN, Daniel, C., H. ,  LIU, Jiwen ,  LUO, Jian ,  MEDINA, Julio, C. ,  QIU, Wei ,  REAGAN, Jeffrey, D. ,  SHARMA, Rajiv ,  SHUTTLEWORTH, Stephen, J. ,  SUN, Ying ,  ZHANG, Jian ,  ZHU, Liusheng ,  MA, Zhihua ,  LIU, Jinqain ,  SCHMITT, Michael J. ,  WANG, Yingcai

IPC分类号： C07D277/24 ,  C07C53/132 ,  C07C213/00 ,  C07C277/00 ,  A61K31/19 ,  A61K31/42 ,  A61K31/215 ,  A61P3/10

CPC分类号： C07D277/24 ,  C07D277/30

公开(公告)号：EP2260017A1

公开(公告)日：2010-12-15

申请号：EP09717135.9

申请日：2009-03-04

申请人： Amgen, Inc

发明人： BROWN, Sean, P. ,  DRANSFIELD, Paul, J. ,  HOUZE, Jonathan ,  KOHN, Todd, J. ,  LIU, Jiwen ,  MEDINA, Julio ,  PATTAROPONG, Vatee ,  SHEN, Wang ,  VIMOLRATANA, Marc ,  WANG, Yingcai ,  YU, Ming ,  ZHU, Liusheng

IPC分类号： C07C59/72 ,  C07D213/64 ,  A61K31/192 ,  A61P3/10 ,  A61P9/00 ,  A61K31/435

CPC分类号： C07C59/72

摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I or the general formula III: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.