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公开(公告)号：EP3300500A1
公开(公告)日：2018-04-04
申请号：EP16730076.3
申请日：2016-05-18
申请人： Amgen Inc.
发明人： CHEN, Ning , CHEN, Xiaoqi , CHEN, Yinhong , CHENG, Alan C. , CONNORS, Richard V. , DEIGNAN, Jeffrey , DRANSFIELD, Paul John , DU, Xiaohui , FU, Zice , HEATH, Julie Anne , HORNE, Daniel B. , HOUZE, Jonathan , KALLER, Matthew R. , KHAKOO, Aarif Yusuf , KOPECKY, David John , LAI, Su-Jen , MA, Zhihua , MCGEE, Lawrence R. , MEDINA, Julio C. , MIHALIC, Jeffrey T. , NISHIMURA, Nobuko , OLSON, Steven H. , PATTAROPONG, Vatee , SWAMINATH, Gayathri , WANG, Xiaodong , YANG, Kevin , YEH, Wen-Chen , DEBENEDETTO, Mikkel V. , FARRELL, Robert P. , HEDLEY, Simon J. , JUDD, Ted C. , KAYSER, Frank
IPC分类号： C07D401/14 , C07D401/04 , C07D413/04 , A61K31/4196 , A61K31/4439 , A61P9/00
CPC分类号： C07D401/14 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/695 , A61K45/06 , C07B57/00 , C07B59/002 , C07B2200/05 , C07B2200/07 , C07C311/13 , C07D211/54 , C07D213/61 , C07D213/71 , C07D213/82 , C07D239/26 , C07D239/30 , C07D239/34 , C07D241/12 , C07D241/18 , C07D241/24 , C07D249/08 , C07D295/16 , C07D401/04 , C07D401/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07F7/08
摘要： where the definitions of the variables are provided herein.
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2.发明公开GEM-DISUBSTITUTED AND SPIROCYCLIC AMINO PYRIDINES/PYRIMIDINES AS CELL CYCLE INHIBITORS 有权创业板和二取代螺环氨基吡啶/嘧啶类ALS细胞周期抑制剂
公开(公告)号：EP2278973A1
公开(公告)日：2011-02-02
申请号：EP09730921.5
申请日：2009-04-06
申请人： Amgen Inc.
发明人： CONNORS, Richard, V. , DAI, Kang , EKSTEROWICZ, John , FAN, Pingchen , FISHER, Benjamin , FU, Jiasheng , LI, Kexue , LI, Zhihong , MCGEE, Lawrence, R. , SHARMA, Rajiv , WANG, Xiaodong
IPC分类号： A61K31/517 , A61K31/519 , A61K31/527 , C07D239/70 , C07D401/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/052 , C07D491/20 , C07D491/22 , C07D491/107 , C07D491/147 , A61P35/00
CPC分类号： C07D471/04 , C07D239/70 , C07D401/12 , C07D471/10 , C07D487/10 , C07D491/10 , C07D491/107 , C07D491/20
摘要： Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are gem-disubstituted or spirocyclic pyridine, pyrimidine and triazine derivatives.
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公开(公告)号：EP3452466A1
公开(公告)日：2019-03-13
申请号：EP17733197.2
申请日：2017-05-02
申请人： Amgen Inc.
发明人： CHEN, Xiaoqi , CHEN, Yinhong , CHENG, Alan C. , CONNORS, Richard V. , DEBENEDETTO, Mikkel V. , DRANSFIELD, Paul John , FU, Zice , HARVEY, James S. , HEATH, Julie Anne , HEDLEY, Simon J. , HOUZE, Jonathan , JUDD, Ted C. , KHAKOO, Aarif Yusuf , KOPECKY, David J. , LAI, Su-Jen , MA, Zhihua , NISHIMURA, Nobuko , OLSON, Steven H. , PATTAROPONG, Vatee , SWAMINATH, Gayathri , WANG, Xiaodong , YEH, Wen-Chen
IPC分类号： C07D401/14 , C07D403/04 , C07D405/14 , C07D403/14 , C07D405/04 , C07D409/14 , C07D471/04 , A61K31/4196 , A61P9/00
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4.发明公开FUSED PYRIDINE, PYRIMIDINE AND TRIAZINE COMPOUNDS AS CELL CYCLE INHIBITORS 审中-公开CONDENSED吡啶，嘧啶化合物和三嗪化合物THAN细胞周期抑制剂
公开(公告)号：EP2231656A1
公开(公告)日：2010-09-29
申请号：EP08867586.3
申请日：2008-12-18
申请人： Amgen Inc.
发明人： CONNORS, Richard, V. , DAI, Kang , EKSTEROWICZ, John , FAN, Pingchen , FISHER, Benjamin , FU, Jiasheng , LI, Kexue , LI, Zhihong , MCGEE, Lawrence, R. , SHARMA, Rajiv , WANG, Xiaodong , MCMINN, Dustin , MIHALIC, Jeffrey , DEIGNAN, Jeffrey
IPC分类号： C07D417/14 , C07D487/04 , C07D487/14 , C07D498/10 , C07D513/14 , A61P35/00 , A61K31/519
CPC分类号： C07D471/14 , A61K31/519 , A61K31/5377 , A61K31/5386 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/14 , C07D491/107 , C07D491/147 , C07D498/04 , C07D498/10 , C07D513/14
摘要： Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are fused pyridine, pyrimide and triazine derivatives.
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5.发明授权PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER 有权PIPERIDINONDERIVATE ALS MDM2-HEMMER ZUR KREBSBEHANDLUNG
公开(公告)号：EP2576510B1
公开(公告)日：2015-04-29
申请号：EP11726581.9
申请日：2011-06-03
申请人： Amgen Inc.
发明人： BARTBERGER, Michael David , GONZALEZ BUENROSTRO, Ana , BECK, Hilary Plake , CHEN, Xiaoqi , CONNORS, Richard Victor , DEIGNAN, Jeffrey , DUQUETTE, Jason , EKSTEROWICZ, John , FISHER, Benjamin , FOX, Brian Matthew , FU, Jiasheng , FU, Zice , GONZALEZ LOPEZ DE TURISO, Felix , GRIBBLE, JR., Michael William , GUSTIN, Darin James , HEATH, Julie Anne , HUANG, Xin , JIAO, Xianyun , JOHNSON, Michael , KAYSER, Frank , KOPECKY, David John , LAI, Sujen , LI, Yihong , LI, Zhihong , LIU, Jiwen , LOW, Jonathan Dante , LUCAS, Brian Stuart , MA, Zhihua , MCGEE, Lawrence , MCINTOSH, Joel , MCMINN, Dustin , MEDINA, Julio Cesar , MIHALIC, Jeffrey Thomas , OLSON, Steven Howard , REW, Yosup , ROVETO, Philip Marley , SUN, Daqing , WANG, Xiaodong , WANG, Yingcai , YAN, Xuelei , YU, Ming , ZHU, Jiang
IPC分类号： C07D211/40 , C07D401/04 , C07D401/06 , C07D407/04 , C07D407/06 , C07D409/04 , C07D413/06 , C07D417/06 , C07D471/20 , C07D279/02 , C07D401/12 , C07D498/08 , C07D498/20 , A61K31/4412 , A61P35/00
CPC分类号： C07D211/76 , C07D221/20 , C07D279/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D407/04 , C07D407/06 , C07D409/04 , C07D409/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/10 , C07D491/08 , C07D491/153 , C07D498/08 , C07D498/14 , C07D498/20
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6.发明公开PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER 有权PIPERIDINONDERIVATE AS MDM2抑制剂用于癌症治疗
公开(公告)号：EP2576510A1
公开(公告)日：2013-04-10
申请号：EP11726581.9
申请日：2011-06-03
申请人： Amgen Inc.
发明人： BARTBERGER, Michael David , GONZALEZ BUENROSTRO, Ana , BECK, Hilary Plake , CHEN, Xiaoqi , CONNORS, Richard Victor , DEIGNAN, Jeffrey , DUQUETTE, Jason , EKSTEROWICZ, John , FISHER, Benjamin , FOX, Brian Matthew , FU, Jiasheng , FU, Zice , GONZALEZ LOPEZ DE TURISO, Felix , GRIBBLE, JR., Michael William , GUSTIN, Darin James , HEATH, Julie Anne , HUANG, Xin , JIAO, Xianyun , JOHNSON, Michael , KAYSER, Frank , KOPECKY, David John , LAI, Sujen , LI, Yihong , LI, Zhihong , LIU, Jiwen , LOW, Jonathan Dante , LUCAS, Brian Stuart , MA, Zhihua , MCGEE, Lawrence , MCINTOSH, Joel , MCMINN, Dustin , MEDINA, Julio Cesar , MIHALIC, Jeffrey Thomas , OLSON, Steven Howard , REW, Yosup , ROVETO, Philip Marley , SUN, Daqing , WANG, Xiaodong , WANG, Yingcai , YAN, Xuelei , YU, Ming , ZHU, Jiang
IPC分类号： C07D211/40 , C07D401/04 , C07D401/06 , C07D407/04 , C07D407/06 , C07D409/04 , C07D413/06 , C07D417/06 , C07D471/20 , C07D279/02 , C07D401/12 , C07D498/08 , C07D498/20 , A61K31/4412 , A61P35/00
CPC分类号： C07D211/76 , C07D221/20 , C07D279/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D407/04 , C07D407/06 , C07D409/04 , C07D409/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/10 , C07D491/08 , C07D491/153 , C07D498/08 , C07D498/14 , C07D498/20
摘要： The present invention provides MDM2 inhibitor compounds of Formula (I), wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
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7.发明授权GEM-DISUBSTITUTED AND SPIROCYCLIC AMINO PYRIDINES/PYRIMIDINES AS CELL CYCLE INHIBITORS 有权创业板和二取代螺环氨基吡啶/嘧啶类ALS细胞周期抑制剂
公开(公告)号：EP2278973B1
公开(公告)日：2011-11-02
申请号：EP09730921.5
申请日：2009-04-06
申请人： Amgen Inc.
发明人： CONNORS, Richard, V. , DAI, Kang , EKSTEROWICZ, John , FAN, Pingchen , FISHER, Benjamin , FU, Jiasheng , LI, Kexue , LI, Zhihong , MCGEE, Lawrence, R. , SHARMA, Rajiv , WANG, Xiaodong
IPC分类号： A61K31/517 , A61K31/519 , A61K31/527 , C07D239/70 , C07D401/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/052 , C07D491/20 , C07D491/22 , C07D491/107 , C07D491/147 , A61P35/00
CPC分类号： C07D471/04 , C07D239/70 , C07D401/12 , C07D471/10 , C07D487/10 , C07D491/10 , C07D491/107 , C07D491/20
摘要： Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are gem-disubstituted or spirocyclic pyridine, pyrimidine and triazine derivatives.
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