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公开(公告)号：EP3020414B1
公开(公告)日：2018-10-24
申请号：EP15190744.1
申请日：2003-09-05
发明人： HUANG, Haichun , VARNUM, Brian , VEZINA, Chris , WITTE, Alison , QIAN, Xueming , MARTIN, Frank , ELLIOTT, Gary
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
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公开(公告)号：EP3020414A1
公开(公告)日：2016-05-18
申请号：EP15190744.1
申请日：2003-09-05
发明人： HUANG, Haichun , VARNUM, Brian , VEZINA, Chris , WITTE, Alison , QIAN, Xueming , MARTIN, Frank , ELLIOTT, Gary
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
摘要翻译： 描述了与白细胞介素-1受体1型（IL-1R1）相互作用的抗体。 描述了通过向IL-1R1施用药学有效量的抗体来治疗IL-1介导的疾病的方法。 描述了使用IL-1R1抗体检测样品中IL-1R1的量的方法。
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公开(公告)号：EP2097097B1
公开(公告)日：2018-05-30
申请号：EP07854887.2
申请日：2007-11-30
发明人： KING, David John , WITTE, Alison , LEBLANC, Heidi N. , THEOLIS, Richard , MASOOD, Asna , YAMANAKA, Mark , ZENS, Kyra D. , DWIGGINS, Sara R. , SPROUL, Tim , RAO-NAIK, Chetana , PASSMORE, David , TOY, Kristopher , TANAMACHI, Dawn M.
IPC分类号： A61K39/00 , A61K39/395 , A61P35/00 , C07K16/28
CPC分类号： C07K16/2803 , A61K39/39558 , A61K45/06 , A61K47/6829 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/3061 , C07K2317/21 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/70 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to CD22 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CD22, as well as methods for treating various cancers and inflammatory and autoimmune disorders using an anti-CD22 antibody of this disclosure.
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公开(公告)号：EP1572946B1
公开(公告)日：2012-03-14
申请号：EP03752058.2
申请日：2003-09-05
申请人： Amgen, Inc. , Medarex, Inc.
发明人： VARNUM, Brian , VEZINA, Chris , WITTE, Alison , QIAN, Xueming , MARTIN, Frank , HUANG, Haichun , ELLIOTT, Gary
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
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公开(公告)号：EP1572946A2
公开(公告)日：2005-09-14
申请号：EP03752058.2
申请日：2003-09-05
申请人： Amgen, Inc.
发明人： VARNUM, Brian , VEZINA, Chris , WITTE, Alison , QIAN, Xueming , MARTIN, Frank , HUANG, Haichun , ELLIOTT, Gary
IPC分类号： C12N1/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
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