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公开(公告)号：EP3020414A1
公开(公告)日：2016-05-18
申请号：EP15190744.1
申请日：2003-09-05
发明人： HUANG, Haichun , VARNUM, Brian , VEZINA, Chris , WITTE, Alison , QIAN, Xueming , MARTIN, Frank , ELLIOTT, Gary
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
摘要翻译： 描述了与白细胞介素-1受体1型（IL-1R1）相互作用的抗体。 描述了通过向IL-1R1施用药学有效量的抗体来治疗IL-1介导的疾病的方法。 描述了使用IL-1R1抗体检测样品中IL-1R1的量的方法。
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公开(公告)号：EP3020414B1
公开(公告)日：2018-10-24
申请号：EP15190744.1
申请日：2003-09-05
发明人： HUANG, Haichun , VARNUM, Brian , VEZINA, Chris , WITTE, Alison , QIAN, Xueming , MARTIN, Frank , ELLIOTT, Gary
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
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公开(公告)号：EP2197911A2
公开(公告)日：2010-06-23
申请号：EP08799478.6
申请日：2008-09-11
申请人： Amgen Inc.
发明人： DILLON, Thomas, M. , BONDARENKO, Pavel , WYPYCH, Jette , ALLEN, Martin , BALLAND, Alain , RICCI, Margaret, Speed , GUO, Amy , SHEN, Wenyan , SUN, Jeonghoon , VEZINA, Chris
IPC分类号： C07K16/00 , C07K16/28 , A61K39/395
CPC分类号： C07K16/245 , C07K16/00 , C07K16/2863 , C07K16/2866 , C07K16/2875 , C07K2317/53 , C07K2317/56
摘要： The present invention is generally directed to methods of producing an increase in the enrichment and/or recovery of preferred forms of monoclonal antibodies. More particularly, the invention relates to methods for eliminating disulfide heterogeneity in the hinge region of recombinant IgG2 antibody proteins.
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公开(公告)号：EP1572946A2
公开(公告)日：2005-09-14
申请号：EP03752058.2
申请日：2003-09-05
申请人： Amgen, Inc.
发明人： VARNUM, Brian , VEZINA, Chris , WITTE, Alison , QIAN, Xueming , MARTIN, Frank , HUANG, Haichun , ELLIOTT, Gary
IPC分类号： C12N1/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
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公开(公告)号：EP1572946B1
公开(公告)日：2012-03-14
申请号：EP03752058.2
申请日：2003-09-05
申请人： Amgen, Inc. , Medarex, Inc.
发明人： VARNUM, Brian , VEZINA, Chris , WITTE, Alison , QIAN, Xueming , MARTIN, Frank , HUANG, Haichun , ELLIOTT, Gary
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
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