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公开(公告)号：EP1572946B1
公开(公告)日：2012-03-14
申请号：EP03752058.2
申请日：2003-09-05
申请人： Amgen, Inc. , Medarex, Inc.
发明人： VARNUM, Brian , VEZINA, Chris , WITTE, Alison , QIAN, Xueming , MARTIN, Frank , HUANG, Haichun , ELLIOTT, Gary
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
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公开(公告)号：EP1711207B1
公开(公告)日：2012-11-28
申请号：EP04814015.6
申请日：2004-12-10
申请人： Medarex, Inc.
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/249 , A61K51/1021 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/76
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3.发明公开HUMAN ANTIBODIES THAT BIND CD22 AND USES THEREOF 有权CD22 BINDENDE MENSCHLICHEANTIKÖRPERUND IHRE VERWENDUNGSZWECKE
公开(公告)号：EP2097097A2
公开(公告)日：2009-09-09
申请号：EP07854887.2
申请日：2007-11-30
申请人： MEDAREX, INC.
发明人： KING, David John , WITTE, Alison , LEBLANC, Heidi N. , THEOLIS, Richard , MASOOD, Asna , YAMANAKA, Mark , ZENS, Kyra, D. , DWIGGINS, Sara, R. , SPROUL, Tim , RAO-NAIK, Chetana , PASSMORE, David , TOY, Kristopher , TANAMACHI, Dawn, M.
IPC分类号： A61K39/00
CPC分类号： C07K16/2803 , A61K39/39558 , A61K45/06 , A61K47/6829 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/3061 , C07K2317/21 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/70 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to CD22 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody- partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CD22, as well as methods for treating various cancers and inflammatory and autoimmune disorders using an anti-CD22 antibody of this disclosure.
摘要翻译： 本公开提供了以高亲和力特别是人单克隆抗体特异性结合CD22的分离的单克隆抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了抗体 - 配偶体分子缀合物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了用于检测CD22的方法，以及使用本公开的抗CD22抗体治疗各种癌症和炎性和自身免疫性疾病的方法。
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公开(公告)号：EP1963371A2
公开(公告)日：2008-09-03
申请号：EP06840171.0
申请日：2006-12-08
申请人： Medarex, Inc.
发明人： KORMAN, Alan J. , SELBY, Mark J. , LU, Li-Sheng , WITTE, Alison , HUANG, Haichun
CPC分类号： C07K16/2827 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07H21/00 , C07K16/30 , C07K16/3015 , C07K2317/14 , C07K2317/21 , C07K2317/40 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92 , C07K2319/55 , C12N15/00 , C12N15/09 , C12N15/62
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.
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5.发明授权HUMAN MONOCLONAL ANTIBODIES TO FUCOSYL-GM1 AND METHODS FOR USING ANTI-FUCOSYL-GM1 有权人类单克隆抗体的岩藻糖基GM1 AND METHOD FOR抗岩藻糖GM1中的应用
公开(公告)号：EP1960434B1
公开(公告)日：2012-07-11
申请号：EP06840172.8
申请日：2006-12-08
申请人： Medarex, Inc.
发明人： VISTICA, Cynthia, A. , HOLMES, Eric, H. , BRAMS, Peter , WITTE, Alison , CARDARELLI, Josephine, M.
IPC分类号： C07K16/30 , A61P35/00 , A61K39/395
CPC分类号： C07K16/3084 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/77
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Fucosyl-GM1 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting Fucosyl-GM1, as well as methods for treating various diseases, including cancer, using anti-Fucosyl-GM1 antibodies.
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公开(公告)号：EP1711207A2
公开(公告)日：2006-10-18
申请号：EP04814015.6
申请日：2004-12-10
申请人： MEDAREX, INC.
IPC分类号： A61K39/395
CPC分类号： C07K16/249 , A61K51/1021 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/76
摘要： The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention.
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7.发明公开HUMAN MONOCLONAL ANTIBODIES TO FUCOSYL-GM1 AND METHODS FOR USING ANTI-FUCOSYL-GM1 有权人类单克隆抗体的岩藻糖基GM1 AND METHOD FOR抗岩藻糖GM1中的应用
公开(公告)号：EP1960434A2
公开(公告)日：2008-08-27
申请号：EP06840172.8
申请日：2006-12-08
申请人： MEDAREX, INC.
发明人： VISTICA, Cynthia, A. , HOLMES, Eric, H. , BRAMS, Peter , WITTE, Alison , CARDARELLI, Josephine, M.
IPC分类号： C07K16/30 , A61P35/00 , A61K39/395
CPC分类号： C07K16/3084 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/77
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Fucosyl-GM1 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting Fucosyl-GM1, as well as methods for treating various diseases, including cancer, using anti-Fucosyl-GM1 antibodies.
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公开(公告)号：EP1781705A2
公开(公告)日：2007-05-09
申请号：EP05787743.3
申请日：2005-06-20
申请人： MEDAREX, INC.
CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/76 , C07K2317/92
摘要： The present invention provides isolated human monoclonal antibodies that bind to IFNAR-1 and that are capable of inhibiting the biological activity of Type I interferons. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting Type I interferon-mediated disorders using the antibodies of the invention, including methods for treating autoimmune disorders, transplant rejection or Graft Versus Host Disease using the antibodies of the invention.
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公开(公告)号：EP3020414B1
公开(公告)日：2018-10-24
申请号：EP15190744.1
申请日：2003-09-05
发明人： HUANG, Haichun , VARNUM, Brian , VEZINA, Chris , WITTE, Alison , QIAN, Xueming , MARTIN, Frank , ELLIOTT, Gary
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
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公开(公告)号：EP3020414A1
公开(公告)日：2016-05-18
申请号：EP15190744.1
申请日：2003-09-05
发明人： HUANG, Haichun , VARNUM, Brian , VEZINA, Chris , WITTE, Alison , QIAN, Xueming , MARTIN, Frank , ELLIOTT, Gary
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
摘要翻译： 描述了与白细胞介素-1受体1型（IL-1R1）相互作用的抗体。 描述了通过向IL-1R1施用药学有效量的抗体来治疗IL-1介导的疾病的方法。 描述了使用IL-1R1抗体检测样品中IL-1R1的量的方法。
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